2,7-二氯-3,6-双[[(1,1-二甲基乙基)二甲基硅]氧基]-9H-氧杂蒽-9-酮 | 121714-20-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 2,7-二氯-3,6-双[[(1,1-二甲基乙基)二甲基硅]氧基]-9H-氧杂蒽-9-酮
• 英文名称: O,O'-bis(tert-butyldimethylsilyl)-2,7-dichloro-3,6-dihydroxyxanth-9-one
• 英文别名: 3,6-Bis{[tert-butyl(dimethyl)silyl]oxy}-2,7-dichloro-9H-xanthen-9-one；3,6-bis[[tert-butyl(dimethyl)silyl]oxy]-2,7-dichloroxanthen-9-one
• CAS: 121714-20-3
• 化学式: C₂₅H₃₄Cl₂O₄Si₂
• 分子量: 525.62
• InChiKey: UVWQZXWKLVBKAO-UHFFFAOYSA-N

物化性质

• 沸点：
  518℃
• 密度：
  1.137
• 闪点：
  267℃

计算性质

• 辛醇/水分配系数(LogP)：
  9.02
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-Bromo-phenyl)-4,7,10-trimethyl-1,4,7,10-tetraaza-cyclododecane 、 2,7-二氯-3,6-双[[(1,1-二甲基乙基)二甲基硅]氧基]-9H-氧杂蒽-9-酮 在 叔丁基锂 作用下， 以 various solvent(s) 为溶剂， 以1.2%的产率得到2,7-Dichloro-6-hydroxy-9-[4-(4,7,10-trimethyl-1,4,7,10-tetrazacyclododec-1-yl)phenyl]xanthen-3-one
  参考文献：
  名称：

  Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications

  摘要：

  DOI：

  10.1002/(sici)1521-3773(20000317)39:6<1052::aid-anie1052>3.0.co;2-5
• 作为产物：
  描述：

  4-氯间苯二酚 在 咪唑 、 zinc(II) chloride 、 三氯氧磷 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 20.0~220.0 ℃ 、253.31 kPa 条件下， 反应 12.0h， 生成 2,7-二氯-3,6-双[[(1,1-二甲基乙基)二甲基硅]氧基]-9H-氧杂蒽-9-酮
  参考文献：
  名称：

  Rational design of novel photoinduced electron transfer type fluorescent probes for sodium cation

  摘要：

  We have developed novel fluorescence probes for sodium cation based on photoinduced electron transfer (PeT). In this study, we rationally designed new probes and succeeded in achieving fluorescence enhancement upon sodium ion binding by reducing the HOMO energy level of the chelator group within the probe molecule. Our new probes show low pH dependency, possibly because of their simple structures. Our results confirm the value of rational probe design based on PeT. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.06.108

文献信息

• Fluorescent probe
  申请人：——

  公开号：US07524974B2

  公开（公告）日：2009-04-28

  A fluorescent probe which is represented by the following formula (I): (wherein, R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species, or the like; R3 represents a monovalent substituent; R4 and R5 represent hydrogen atom or a halogen atom; R6 represents hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, provided that a combination of R1, R2, and R3 provides (1) substantially high electron density of the benzene ring to which said groups bind, so that the compound represented by the formula (I) is substantially no fluorescent before the trapping of proton, or the like, and (2) substantially reduced electron density of the benzene ring to which said groups bind, so that a compound after the trapping, which is derived from the compound represented by the formula (I) is substantially highly fluorescent after the trapping of proton or the like). A fluorescent probe having an excellent fluorescence property is provided.

  一种荧光探针，其由以下公式（I）表示： （其中，R1和R2代表氢原子，或用于捕获质子、金属离子或活性氧物种等的取代基；R3代表一价取代基；R4和R5代表氢原子或卤素原子；R6代表氢原子、烷基羰基基团或烷基羰氧甲基基团，前提是R1、R2和R3的组合提供（1）苯环的电子密度显著高，使得由公式（I）表示的化合物在捕获质子等之前基本不发光，以及（2）苯环的电子密度显著降低，使得捕获后的化合物，即由公式（I）表示的化合物衍生物，在捕获质子等后基本上具有高荧光性）。提供了具有优异荧光性能的荧光探针。
• Fluorescent ion indicators and their applications
  申请人：Diwu Zhenjun

  公开号：US08779165B2

  公开（公告）日：2014-07-15

  Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.

  用于制备荧光金属离子指示剂的荧光染料，这些荧光指示剂本身，以及使用这些荧光指示剂来检测、区分和量化金属阳离子。
• Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications
  作者：Tomoya Hirano、Kazuya Kikuchi、Yasuteru Urano、Tsunehiko Higuchi、Tetsuo Nagano

  DOI：10.1002/(sici)1521-3773(20000317)39:6<1052::aid-anie1052>3.0.co;2-5

  日期：2000.3.17
• Rational design of novel photoinduced electron transfer type fluorescent probes for sodium cation
  作者：Suguru Kenmoku、Yasuteru Urano、Koujirou Kanda、Hirotatsu Kojima、Kazuya Kikuchi、Tetuso Nagano

  DOI：10.1016/j.tet.2004.06.108

  日期：2004.11

  We have developed novel fluorescence probes for sodium cation based on photoinduced electron transfer (PeT). In this study, we rationally designed new probes and succeeded in achieving fluorescence enhancement upon sodium ion binding by reducing the HOMO energy level of the chelator group within the probe molecule. Our new probes show low pH dependency, possibly because of their simple structures. Our results confirm the value of rational probe design based on PeT. (C) 2004 Elsevier Ltd. All rights reserved.