2-(1-环丙基-乙胺基)-乙醇 | 42977-88-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(1-环丙基-乙胺基)-乙醇
• 英文名称: 2-(1-cyclopropyl-ethylamino)-ethanol
• 英文别名: 2-(1-Cyclopropylethylamino)ethanol
• CAS: 42977-88-8
• 化学式: C₇H₁₅NO
• 分子量: 129.202
• InChiKey: WDCSLFGADZJTRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环丙甲基酮 、 C.I.酸性橙108 在 titanium(IV) isopropylate 、 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以86%的产率得到2-(1-环丙基-乙胺基)-乙醇
  参考文献：
  名称：

  Efficient preparation of secondary aminoalcohols through a Ti(IV) reductive amination procedure. Application to the synthesis and antibacterial evaluation of new 3β-N-[hydroxyalkyl]aminosteroid derivatives

  摘要：

  An efficient method for the synthesis of various secondary aminoalcohols through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, different ketones gave the expected products in moderate to excellent yields up to 89% in numerous cases. A series of 3 beta-N-[hydroxyalkyl]aminosteroid derivatives were prepared according to this methodology and evaluated for their in vitro antimicrobial properties against human pathogens. All the compounds showed moderate to excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with Minimum Inhibitory Concentrations (MICs) varying from 3.12 to 25 mu g/mL. No significant antibacterial activities are encountered against Gram-negative bacteria. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.055

文献信息

• [EN] CYCLOALKYL-BASED AND HETEROCYCLOALKYL-BASED INHIBITORS, PREPARATION METHOD THEREFOR AND USE THEREOF<br/>[FR] INHIBITEURS À BASE DE GROUPES CYCLOALKYLE ET HÉTÉROALKYLE, PROCÉDÉ DE PRÉPARATION ASSOCIÉ ET UTILISATION ASSOCIÉE<br/>[ZH] 环烷基类和杂环烷基类抑制剂及其制备方法和应用
  申请人：SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD

  公开号：WO2021078285A1

  公开（公告）日：2021-04-29

  涉及环烷基类和杂环烷基类抑制剂及其制备方法和应用。具体地，抑制剂具有式(I)所示结构，还公开了所述化合物的制备方法及其作为KRAS G12C抑制剂的用途，对KRAS G12C具有很好的选择性抑制作用且具有更好的药效学、药代动力学性能和更低的毒副作用。
• [EN] CYCLOALKYL AND HETERO-CYCLOALKYL INHIBITORS, PREPARATION METHODS THEREFOR, AND USE THEREOF<br/>[FR] INHIBITEURS DE CYCLOALKYLES ET D'HÉTÉRO-CYCLOALKYLES, LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION<br/>[ZH] 环烷基类和杂环烷基类抑制剂及其制备方法和应用
  申请人：SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD

  公开号：WO2021078312A1

  公开（公告）日：2021-04-29

  一种环烷基类和杂环烷基类抑制剂及其制备方法和应用。具有式（I）所示结构，还公开了所述化合物的制备方法及其作为KRASG12C抑制剂的用途，对KRASG12C具有很好的选择性抑制作用且具有更好的药效学、药代动力学性能和更低的毒副作用。
• Antifertility activity of some .beta.-amino alcohols
  作者：Duane F. Morrow、Porter C. Johnson、Houshang Torabi、David Williams、Donald L. Wedding、Joe W. Craig、Robert F. Majewski、John P. Braselton、Duane G. Gallo

  DOI：10.1021/jm00264a046

  日期：1973.6
• Efficient preparation of secondary aminoalcohols through a Ti(IV) reductive amination procedure. Application to the synthesis and antibacterial evaluation of new 3β-N-[hydroxyalkyl]aminosteroid derivatives
  作者：Chanaz Salmi、Céline Loncle、Yves Letourneux、Jean Michel Brunel

  DOI：10.1016/j.tet.2008.02.055

  日期：2008.5

  An efficient method for the synthesis of various secondary aminoalcohols through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, different ketones gave the expected products in moderate to excellent yields up to 89% in numerous cases. A series of 3 beta-N-[hydroxyalkyl]aminosteroid derivatives were prepared according to this methodology and evaluated for their in vitro antimicrobial properties against human pathogens. All the compounds showed moderate to excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with Minimum Inhibitory Concentrations (MICs) varying from 3.12 to 25 mu g/mL. No significant antibacterial activities are encountered against Gram-negative bacteria. (c) 2008 Elsevier Ltd. All rights reserved.