2-(1-甲基-1H-咪唑-2-基)哌啶 | 933713-92-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(1-甲基-1H-咪唑-2-基)哌啶
• 英文名称: 2-(1-methyl-1H-imidazol-2-yl)piperidine
• 英文别名: 2-(1-methylimidazol-2-yl)piperidine
• CAS: 933713-92-9
• 化学式: C₉H₁₅N₃
• 分子量: 165.238
• InChiKey: IEYNKTLWCMCJTK-UHFFFAOYSA-N

物化性质

• 沸点：
  330.5±35.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  29.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-甲基-1H-咪唑-2-基)哌啶 、 5-(2,3-Dichlorophenoxy)-1,3-dimethylpyrazole-4-carbaldehyde 在 三乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 [5-(2,3-Dichlorophenoxy)-1,3-dimethylpyrazol-4-yl]-[2-(1-methylimidazol-2-yl)piperidin-1-yl]methanone
  参考文献：
  名称：

  Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries

  摘要：

  Optimization of a high-throughput screening hit led to the discovery of a new series of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as highly potent agonists of TGR5. This novel chemotype was rapidly developed through iterative combinatorial library synthesis. It was determined that in vitro agonist potency correlated with functional activity data from human peripheral blood monocytes. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.12.076

文献信息

• Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
  作者：Zhijian Zhao、Ronald G. Robinson、Stanley F. Barnett、Deborah Defeo-Jones、Raymond E. Jones、George D. Hartman、Hans E. Huber、Mark E. Duggan、Craig W. Lindsley

  DOI：10.1016/j.bmcl.2007.11.015

  日期：2008.1

  This letter describes the development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved aqueous solubility (similar to 18 mg/mL) that translates into enhanced cell activity and caspase-3 induction. (C) 2007 Elsevier Ltd. All rights reserved.
• Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries
  作者：Allyn T. Londregan、David W. Piotrowski、Kentaro Futatsugi、Joseph S. Warmus、Markus Boehm、Philip A. Carpino、Janice E. Chin、Ann M. Janssen、Nicole S. Roush、Joanne Buxton、Terri Hinchey

  DOI：10.1016/j.bmcl.2012.12.076

  日期：2013.3

  Optimization of a high-throughput screening hit led to the discovery of a new series of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as highly potent agonists of TGR5. This novel chemotype was rapidly developed through iterative combinatorial library synthesis. It was determined that in vitro agonist potency correlated with functional activity data from human peripheral blood monocytes. (c) 2013 Elsevier Ltd. All rights reserved.