2-(2,4-二氯苯甲酰基)苯甲酸 | 61959-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2,4-二氯苯甲酰基)苯甲酸
• 英文名称: 2-(2,4-dichloro-benzoyl)-benzoic acid
• 英文别名: 2-(2,4-Dichlor-benzoyl)-benzoesaeure；2-(2,4-Dichlorobenzoyl)benzoic acid
• CAS: 61959-32-8
• 化学式: C₁₄H₈Cl₂O₃
• mdl: MFCD01013746
• 分子量: 295.122
• InChiKey: SSRBKRHBIFAERH-UHFFFAOYSA-N

物化性质

• 熔点：
  100-101 °C
• 沸点：
  499.9±40.0 °C(Predicted)
• 密度：
  1.446±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2,4-二氯苯甲酰基)苯甲酸 在 硫酸 作用下， 生成 1,3-二氯蒽醌
  参考文献：
  名称：

  Notes

  摘要：

  DOI：

  10.1039/jr9310002829
• 作为产物：
  描述：

  苯酐 、 1,3-二氯苯 在 三氯化铝 作用下， 生成 2-(2,4-二氯苯甲酰基)苯甲酸
  参考文献：
  名称：

  A rare association between malignant mediastinal seminoma and other malignant neoplasms

  摘要：

  Primary malignant mediastinal seminomas (PMMS) are rare tumors accounting for 1-6% of all mediastinal tumors. PMMS mostly affect young men, arising from primordial germ cells that abnormally migrate from the ectoderm of the yolk sac to the gonadal region. They are clinically and biologically distinct from primary testicular tumors and seem to have a worse prognosis. Due to the rarity of the disease, the choice of treatment is a matter of debate. Literature data do not show any association between this kind of tumor and malignant Schwannoma or thyroid carcinoma. In this report we describe the case of a patient affected by PMMS and 12 yr later by a malignant brachial plexus Schwannoma and papillary thyroid carcinoma (PTC). Since both mediastinal seminoma and Schwannoma were treated with surgery followed by local radiotherapy, we were not able to ascertain if either PTC or Schwannoma had been induced by radiotherapy or represented a casual neoplastic association. (C) 2002, Editrice Kurtis.

  DOI：

  10.1007/bf03344021

文献信息

• Silver halide photographic light-sensitive material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04500636A1

  公开（公告）日：1985-02-19

  A silver halide photographic light-sensitive material which comprises a light-sensitive silver halide emulsion layer having associated therewith a blocked photographic agent, said blocked photographic agent being represented by the following general formula (I): ##STR1## wherein A represents a photographic agent moiety which is attached to a blocking moiety through a hetero atom; Z represents a divalent linkage group; p represents 0 or 1; X and Y each represents a substituent: m represents an integer of 0 to 4: and n represents an integer of 0 to 5.

  一种银卤片光敏材料，包括具有阻滞型摄影试剂的光敏银卤乳胶层，所述阻滞型摄影试剂由以下通式（I）表示： ##STR1## 其中，A表示通过杂原子与阻滞基团结合的摄影试剂基团；Z表示双价连结基团；p表示0或1；X和Y分别表示取代基；m表示0至4的整数；n表示0至5的整数。
• Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents
  申请人：STERLING WINTHROP INC.

  公开号：EP0597540A1

  公开（公告）日：1994-05-18

  Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, wherein    A is an aryl, cycloalkyl or hetaryl or substituted aryl ring    R¹ is hydrogen, alkyl, aralkyl, aryl, hetaryl or substituted aryl;    R² is hydrogen, alkyl, aralkyl, aryl or substituted alkyl or aryl;    R³ is alkyl, aryl, aralkyl, hetaryl or heteroatom substituted alkyl, aryl, aralkyl or hetaryl;    R⁴ is hydrogen, alkyl or substituted alkyl;    R⁵ is hydrogen, alkyl, aryl, aralkyl, hetaryl or substituted aryl, pharmaceutical compositions containing these and methods of treating cardiac arrhythmia with the compounds of formula XXXVI are disclosed.

  式 XXXVI 的芳基融合-2,4-二氮杂卓和正十八烷基融合-2,4-二氮杂卓、 其中 A 是芳基环、环烷基环、正十八烷基环或取代的芳基环 R¹ 是氢、烷基、芳烷基、芳基、正烷基或取代的芳基； R² 是氢、烷基、芳烷基、芳基或取代的烷基或芳基； R³ 是烷基、芳基、芳烷基、正烷基或杂原子取代的烷基、芳基、芳烷基或正烷基； R⁴ 是氢、烷基或取代的烷基； R⁵ 是氢、烷基、芳基、芳烷基、庚基或取代的芳基、 本发明公开了含有这些化合物的药物组合物以及用式 XXXVI 化合物治疗心律失常的方法。
• Barnett; Goodway; Watson, Chemische Berichte, 1933, vol. 66, p. 1876,1886
  作者：Barnett、Goodway、Watson

  DOI：——

  日期：——
• Esters of aroyl benzoic acids
  申请人：AMERICAN CYANAMID CO

  公开号：US02233513A1

  公开（公告）日：1941-03-04
• US4188330A
  申请人：——

  公开号：US4188330A

  公开（公告）日：1980-02-12