阿利马朵 | 52742-40-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 阿利马朵
• 中文别名: 阿利马多
• 英文名称: 1,1-Diphenyl-1-methoxy-3-allylaminopropan
• 英文别名: 1,1-diphenyl-1-methoxy-3-allylaminopropane；alimadol；3-methoxy-3,3-diphenyl-N-prop-2-enylpropan-1-amine
• CAS: 52742-40-2
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: QFSWEWNANAHUNE-UHFFFAOYSA-N

物化性质

• 沸点：
  404.8±45.0 °C(Predicted)
• 密度：
  1.008±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  阿利马朵 生成 1,1-二苯乙烯
  参考文献：
  名称：

  KNOPP, CH.;BERNDT, E., SCI. PHARM., 1984, 52, N 3, 240-246

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-Diphenyl-1-methoxy-3-aminopropan 在 吡啶 作用下， 以 苯 为溶剂， 生成 阿利马朵
  参考文献：
  名称：

  CH596144

  摘要：

  公开号：

文献信息

• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• 1,1-Diphenyl-1-lower alkoxy-amino-alkanes and the salts thereof
  申请人：Chemie Linz Aktiengesellschaft

  公开号：US03960960A1

  公开（公告）日：1976-06-01

  Basic ethers having the general formula: ##EQU1## in which R is lower alkyl, R.sub.1 is hydrogen, lower alkyl, allyl or benzyl, R.sub.2 is alkenyl, aralkenyl, optionally substituted by alkoxy, haloalkenyl, alkinyl, cycloalkyl or cycloalkylidenemethyl and R.sub.3 is hydrogen or methyl and their salts, which compounds have good analgesic and morphineantagonistic action.

  具有以下一般式的基础醚类化合物：##EQU1## 其中 R 为低级烷基，R.sub.1 为氢、低级烷基、烯丙基或苄基，R.sub.2 为烯丙基、芳基烯丙基，可选地被烷氧基、卤代烯丙基、炔基、环烷基或环烷基甲基取代，R.sub.3 为氢或甲基，以及它们的盐。这些化合物具有良好的镇痛作用和吗啡拮抗作用。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration
  申请人：Counts David F.

  公开号：US10463611B2

  公开（公告）日：2019-11-05

  The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a water-soluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound. In some embodiments, the formulation of the invention are designed to extend release of the pharmaceutically active organic compound for about 3 hours to about 8 hours, thereby enabling preparation of an extended release formulation for any pharmaceutically active compound with a half-life of from about 16 hours to about 21 hours.

  本公开提供了一种用于口服的每日一次水溶性药用活性制剂。在某些实施方案中，该组合物包括掺入小颗粒中的水溶性药用活性有机化合物，每个颗粒都有一个水溶性药用活性有机化合物或其可接受盐的核心，该核心与药学上可接受的药物结合聚合物可逆结合。组合物的核心由不溶性透水膜包围，该膜能够延迟其中的药用活性化合物的溶解，并延长药用活性化合物的释放时间。在某些实施方案中，本发明的制剂可将药用活性有机化合物的释放时间延长约 3 小时至约 8 小时，从而能够制备半衰期为约 16 小时至约 21 小时的任何药用活性化合物的缓释制剂。
• Ligands of the mu, kappa, and delta opioid receptors
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US11213518B2

  公开（公告）日：2022-01-04

  Ligands of the mu, kappa, and delta opioid receptors and methods of using them are disclosed. In particular, the invention relates to the discovery of new opioid receptor ligands based on molecular dynamics simulations of conformational states of the μ opioid receptor and the use of the identified opioid receptor ligands as analgesics, anti-diarrheal agents, and overdose reversal agents.

  本发明公开了μ、卡帕和δ阿片受体的配体及其使用方法。特别是，本发明涉及基于对μ阿片受体构象状态的分子动力学模拟发现新的阿片受体配体，以及将所发现的阿片受体配体用作镇痛剂、止泻剂和过量逆转剂。