洋地黄毒苷NHS酯 | 129273-26-3

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 洋地黄毒苷NHS酯
• 英文名称: (2,5-dioxopyrrolidin-1-yl) 6-[[2-[[(3S,5R,8R,9S,10S,12R,13S,17R)-12,14-dihydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]acetyl]amino]hexanoate
• CAS: 129273-26-3
• 化学式: C₃₅H₅₀N₂O₁₀
• 分子量: 658.8
• InChiKey: KHNDABJZSPPYLE-MZARVJLWSA-N

物化性质

• 密度：
  1.33±0.1 g/cm3(Predicted)
• 溶解度：
  在DMF中可溶

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  47
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  169
• 氢给体数：
  3
• 氢受体数：
  10

安全信息

• WGK Germany：
  2

文献信息

• NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3562842A1

  公开（公告）日：2019-11-06
• [EN] NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF<br/>[FR] NOUVEL ANTICORPS MONOCLONAL SPÉCIFIQUE À LA BIOTINE, ET SON UTILISATION
  申请人：HOFFMANN LA ROCHE

  公开号：WO2018122204A1

  公开（公告）日：2018-07-05

  The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
• [EN] NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF<br/>[FR] NOUVEL ANTICORPS MONOCLONAL SPÉCIFIQUE DE LA BIOTINE, ET SON UTILISATION
  申请人：HOFFMANN LA ROCHE

  公开号：WO2018122043A1

  公开（公告）日：2018-07-05

  The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
• [EN] NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF<br/>[FR] NOUVEL ANTICORPS MONOCLONAL SPÉCIFIQUE À LA BIOTINE ET SON UTILISATION
  申请人：HOFFMANN LA ROCHE

  公开号：WO2018122205A2

  公开（公告）日：2018-07-05

  The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.