N-hydroxy-N-(2-methylphenyl)nitrous amide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-hydroxy-N-(2-methylphenyl)nitrous amide
• 化学式: C₇H₈N₂O₂
• 分子量: 152.15
• InChiKey: DBKRHBLUSACFDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Process for the preparation of arylhydroxylamines
  申请人：MALLINCKRODT, INC.(a Missouri corporation)

  公开号：EP0086363A1

  公开（公告）日：1983-08-24

  A process for producing arylhydroxylamines in high yield with minimal formation of by-product arylamines. A charge mixture is prepared comprising a nitroaryl compound, a platinum catalyst, a base, a sulfur compound, and a solvent for the nitroaryl compound. The sulfur compound is one in which divalent sulfur is bonded to two other moieties or a compound reducible to such divalent sulfur compound under catalytic hydrogenation conditions. Hydrogen is introduced into the mixture while the mixture is agitated at a temperature in a range of 0-40 °C thereby reducing the nitro group of the nitroaryl compound to the hydroxylamine group.

  一种生产芳基羟胺的工艺，产量高，副产物芳基胺的形成量极少。 制备一种由硝基芳基化合物、铂催化剂、碱、硫化合物和硝基芳基化合物溶剂组成的加料混合物。 硫化合物是二价硫与两个其他分子键合的化合物，或者是在催化氢化条件下可还原成这种二价硫化合物的化合物。 在0-40℃的温度范围内搅拌混合物时，向混合物中通入氢气，从而将硝基芳基化合物的硝基还原成羟胺基团。
• TOPICAL DELIVERY OF A NITRIC OXIDE DONOR TO IMPROVE BODY AND SKIN APPEARANCE
  申请人：Strategic Science & Technologies, LLC

  公开号：EP1732577A2

  公开（公告）日：2006-12-20
• EP1732577A4
  申请人：——

  公开号：EP1732577A4

  公开（公告）日：2009-03-18
• Topical Delivery of a Nitric Oxide Donor to Improve and Skin Appearance
  申请人：Fossel Eric Thor

  公开号：US20080045909A1

  公开（公告）日：2008-02-21

  This invention generally relates to improvement of the body and skin appearance, for example enhancing the appearance of sagging, wrinkled, or cellulite-afflicted areas of the skin and body, through the local delivery of a nitric oxide donor, for example, using delivery vehicles such as lotions, creams, liquids, and/or transdermal patches. In some embodiments, a delivery vehicle containing a nitric oxide donor, for example, L-arginine (an important biological precursor) or its derivatives in a sufficient concentration to improve the appearance of a selected area of the body may be applied. In certain cases, one or more agents may also be included that aid in the transfer of the nitric oxide donor into the tissue, which may overcome the resistance to transfer into the skin. Non-limiting examples of suitable agents include agents able to create hostile biophysical environments, for instance, choline chloride, magnesium chloride, and/or sodium chloride.
• NITRIC OXIDE-RELEASING 3D-PRINTING COMPOSITIONS AND USES THEREOF
  申请人：Virginia Commonwealth University

  公开号：US20210301135A1

  公开（公告）日：2021-09-30

  A nitric oxide-releasing 3D printing ink is described for its composition and uses in fabricating a plurality of types of nitric oxide-releasing medical devices. The printing ink composition comprises a mixture of at least one nitric oxide donor and at least one polymer. The nitric oxide-releasing medical device is manufactured by 3D printing technology and provides antimicrobial and/or antithrombus effects by releasing nitric oxide in the presence of moisture.