2-(4-Iodoanilino)-5-methoxybenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Iodoanilino)-5-methoxybenzoic acid
• 化学式: C₁₄H₁₂INO₃
• 分子量: 369.15
• InChiKey: XLTVXGORWXCJNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Combination chemotherapy
  申请人：——

  公开号：US20040171632A1

  公开（公告）日：2004-09-02

  Mitotic inhibitors such as paclitaxel have improved antitumor activity when used in combination with a selective MEK inhibitor, especially a phenyl amine compound of Formula I and II: 1

  有丝分裂抑制剂如紫杉醇在与选择性MEK抑制剂结合使用时，特别是Formula I和II的苯胺化合物，已提高抗肿瘤活性。
• 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives
  申请人：——

  公开号：US20020022647A1

  公开（公告）日：2002-02-21

  Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula 1 where R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen or substituent groups such as alkyl, and where R 7 is hydrogen or an organic radical, and Z is COOR 7 , tetrazolyl, CONR 6 R 7 , or CH 2 OR 7 , are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.

  苯基氨基苯甲酸，苯甲酰胺和苄醇衍生物的公式1，其中R1、R2、R3、R4、R5和R6为氢或取代基团，如烷基，其中R7为氢或有机基团，Z为COOR7、四唑基、CONR6R7或CH2OR7，是MEK的有效抑制剂，因此可用于治疗癌症和其他增殖性疾病，如炎症、银屑病和再狭窄，以及中风、心力衰竭和免疫缺陷病。
• Treatment of asthma with MEK inhibitors
  申请人：——

  公开号：US20040141924A1

  公开（公告）日：2004-07-22

  This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of Formula I and II: 1

  本发明提供了一种通过向需要治疗的患者施用有效量的选择性MEK抑制剂，特别是公式I和II的苯胺，来预防或治疗哮喘的方法。
• Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1262176A1

  公开（公告）日：2002-12-04

  The present invention provides a method of treating or preventing neutrophil chemotaxis. Specifically, the present invention provides a method of treating or preventing neutrophil migration by administering to a patient a MEK inhibitor.

  本发明提供了一种治疗或预防中性粒细胞趋化的方法。具体而言，本发明提供了一种通过向患者施用MEK抑制剂治疗或预防中性粒细胞迁移的方法。
• 2-(4-BROMO OR 4-IODO PHENYLAMINO) BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0993437A1

  公开（公告）日：2000-04-19