This invention provides an improved process for cis-1-2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine of following formula:
which is an intermediate for the preparation of (-)cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-5,6,7,8-tetrahydronaphthalene-2-ol which is useful for the treatment of osteoporosis.
本发明提供了一种下式的顺式-1-2-[4-(6-甲氧基-
2-苯基-1,2,3,4-四氢萘-1-基)苯氧基]乙基}
吡咯烷的改进工艺:
是制备(-)顺式-6-苯基-5-[4-(2-
吡咯烷-1-基乙氧基)苯基]-5,6,7,8-四氢
萘-2-醇的中间体,可用于治疗骨质疏松症。