8-[[5-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazine-2(3H)-yl)phenoxyl]-2-hydroxyphenyl]sulfonyl]-spiro[8-azabicyclo[3.2.1]octane-3,2'-(3'H)-dihydro-furan] | 477186-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-[[5-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazine-2(3H)-yl)phenoxyl]-2-hydroxyphenyl]sulfonyl]-spiro[8-azabicyclo[3.2.1]octane-3,2'-(3'H)-dihydro-furan]
• 英文别名: 8-[[5-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazine-2(3H)-yl)phenoxy]-2-hydroxyphenyl]sulfonyl]-spiro[8-azabicyclo[3.2.1]octane-3,2'-(3'H)-dihydro-furan]；2-[3,5-dichloro-4-(4-hydroxy-3-spiro[3H-furan-2,3'-8-azabicyclo[3.2.1]octane]-8'-ylsulfonylphenoxy)phenyl]-1,2,4-triazine-3,5-dione
• CAS: 477186-14-4
• 化学式: C₂₅H₂₂Cl₂N₄O₇S
• 分子量: 593.444
• InChiKey: IKXXLQGXJDLJRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Medical use of thyromimetic compounds to treat hair loss and compositions
  申请人：Pfizer Products Inc.

  公开号：EP1262177A2

  公开（公告）日：2002-12-04

  The present invention provides methods and compositions for treating hair loss, including arresting and/or reversing hair loss and/or promoting hair growth, in mammals, such as humans, companion animals and livestock, using certain thyromimetic compounds.

  本发明提供了利用某些拟甲状腺化合物治疗哺乳动物（如人类、伴侣动物和家畜）脱发的方法和组合物，包括阻止和/或逆转脱发和/或促进毛发生长。
• Method of treating hair loss using thyromimetic compounds
  申请人：——

  公开号：US20030007941A1

  公开（公告）日：2003-01-09

  The present invention provides methods and compositions for treating hair loss, including arresting and/or reversing hair loss and/or promoting hair growth, in mammals, such as humans, companion animals and livestock, using certain thyromimetic compounds.

  本发明提供了利用某些拟甲状腺化合物治疗哺乳动物（如人类、伴侣动物和家畜）脱发的方法和组合物，包括阻止和/或逆转脱发和/或促进毛发生长。
• 6-azauracil derivatives as thyroid receptor ligands
  申请人：Pfizer Products Inc.

  公开号：EP1088819B1

  公开（公告）日：2005-06-15
• Method of promoting nail growth using thyromimetic compounds
  申请人：Doherty Niall S.

  公开号：US20110098303A1

  公开（公告）日：2011-04-28

  The present invention provides methods and compositions for increasing the rate of nail growth in mammals, especially humans, using thyromimetic compounds.
• US6787652B1
  申请人：——

  公开号：US6787652B1

  公开（公告）日：2004-09-07