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3-[8-(5,5-Diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione

中文名称
——
中文别名
——
英文名称
3-[8-(5,5-Diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione
英文别名
——
3-[8-(5,5-Diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione化学式
CAS
——
化学式
C30H58N2O4
mdl
——
分子量
510.8
InChiKey
JJGWNTOQCUZMEP-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    7.9
  • 重原子数:
    36
  • 可旋转键数:
    23
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.93
  • 拓扑面积:
    70.1
  • 氢给体数:
    1
  • 氢受体数:
    4

文献信息

  • Ether compounds, compositions, and uses thereof
    申请人:Esperion Therapeutics, Inc.
    公开号:EP1862444A2
    公开(公告)日:2007-12-05
    The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicaemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycaemic agents.
    本发明涉及新型醚类化合物、包含醚类化合物的组合物,以及用于治疗和预防心血管疾病、血脂异常、蛋白异常和糖代谢紊乱的方法,其中包含施用一种包含醚类化合物的组合物。本发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体增殖物激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾病、癌症、炎症和阳痿。在某些实施方案中,本发明的化合物、组合物和方法可与其他治疗药物(如降胆固醇药和降血糖药)联合使用。
  • Ether compounds
    申请人:Esperion Therapeutics, Inc.
    公开号:US20030065195A1
    公开(公告)日:2003-04-03
    The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    本发明涉及新型醚类化合物、包含醚类化合物的组合物,以及用于治疗和预防心血管疾病、血脂异常、蛋白异常和葡萄糖代谢紊乱的方法,其中包含施用一种包含醚类化合物的组合物。本发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾病、癌症、炎症和阳痿。在某些实施方案中,本发明的化合物、组合物和方法可与其他治疗药物(如降胆固醇药和降血糖药)联合使用。
  • Methods for synthesizing ether compounds and intermediates therefor
    申请人:Esperion Therapeutics, Inc.
    公开号:US20030125559A1
    公开(公告)日:2003-07-03
    The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    本发明涉及新型醚类化合物、包含醚类化合物的组合物,以及用于治疗和预防心血管疾病、血脂异常、蛋白异常和葡萄糖代谢紊乱的方法,其中包含施用一种包含醚类化合物的组合物。本发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾病、癌症、炎症和阳痿。在某些实施方案中,本发明的化合物、组合物和方法可与其他治疗药物(如降胆固醇药和降血糖药)联合使用。
  • Compositions comprising ether compounds and pharmaceutical uses therefor
    申请人:Esperion Therapeutics, Inc.
    公开号:US20030149094A1
    公开(公告)日:2003-08-07
    The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    本发明涉及新型醚类化合物、包含醚类化合物的组合物,以及用于治疗和预防心血管疾病、血脂异常、蛋白异常和葡萄糖代谢紊乱的方法,其中包含施用一种包含醚类化合物的组合物。本发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾病、癌症、炎症和阳痿。在某些实施方案中,本发明的化合物、组合物和方法可与其他治疗药物(如降胆固醇药和降血糖药)联合使用。
  • COMPOSITIONS COMPRISING ETHER COMPOUNDS AND PHARMACEUTICAL USES THEREFOR
    申请人:Dasseux Jean-Louis Henri
    公开号:US20100256209A1
    公开(公告)日:2010-10-07
    The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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