3-[3-[2-[Bis(2-aminoethyl)amino]ethylamino]propyl]-1-phenyl-8-(4-propan-2-ylcyclohexyl)-1,3,8-triazaspiro[4.5]decan-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-[3-[2-[Bis(2-aminoethyl)amino]ethylamino]propyl]-1-phenyl-8-(4-propan-2-ylcyclohexyl)-1,3,8-triazaspiro[4.5]decan-4-one
• 化学式: C₃₁H₅₅N₇O
• 分子量: 541.8
• InChiKey: GCCKOUMVRPLOCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  39
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  94.1
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Nociceptin Analogues and Uses Thereof
  申请人：Hansen Lars Bo Laurenborg

  公开号：US20080287478A1

  公开（公告）日：2008-11-20

  The present invention relates to nociceptin analogues and uses thereof to modulate biological functions. In one aspect, the invention provides modified triazo-spiro compounds that include at least one specialized chemical group that is bound to the compounds. The invention has a wide range of applications including providing a new class of therapeutically useful aquatics.

  本发明涉及痛觉素类似物及其用于调节生物功能的用途。在一个方面，本发明提供了经过改性的三唑-螺化合物，其中至少包括一个专门的化学基团与化合物结合。本发明具有广泛的应用，包括提供一类新的治疗有用的水生生物。
• TRIAZA-SPIRO COMPOUNDS AS NOCICEPTIN ANALOGUES AND USES THEREOF
  申请人：Zealand Pharma A/S

  公开号：EP1628978A2

  公开（公告）日：2006-03-01
• [EN] NOCICEPTIN ANALOGUES AND USES THEREOF<br/>[FR] ANALOGUES DE NOCICEPTINE ET LEURS UTILISATIONS
  申请人：ZEALAND PHARMA AS

  公开号：WO2004104004A2

  公开（公告）日：2004-12-02

  The present invention. relates to nociceptin analogues represented by the following formula I: and uses thereof to modulate biological functions. In one aspect, the invention provides modified triaza-spiroo compounds that include at least one specialized chemical group that is bound to the compounds. The invention has a wide range of applications including providing a. new class of therapeutically useful aquaretics.