O-[(6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-3-yl)methyl] N-methylcarbamothioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: O-[(6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-3-yl)methyl] N-methylcarbamothioate
• 化学式: C₁₅H₂₂N₂O₃S
• 分子量: 310.4
• InChiKey: CYBYXAQAVVVIGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  75
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• TETRAHYDRO ISOQUINO LINEALKANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
  申请人：SK Corporation

  公开号：EP1149079B1

  公开（公告）日：2004-04-21
• US5955471A
  申请人：——

  公开号：US5955471A

  公开（公告）日：1999-09-21
• [EN] TETRAHYDRO ISOQUINO LINEALKANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME<br/>[FR] DERIVES DE TETRAHYDRO ISOQUINO LINEALCANOL ET COMPOSITIONS PHARMACEUTIQUES CONTENANTS CES DERIVES
  申请人：SK CORP

  公开号：WO2000046204A1

  公开（公告）日：2000-08-10

  The present invention provides novel 1,2,3,4-tetrahydro isoquinoline carbamate and thiocarbamate derivatives represented by Formula (I), wherein: X1 and X2 are the same or different from each other and independently represent a member selected from the group consisting of hydrogen, alkyl, alkoxy, thioalkoxy, halogen, hydroxy, nitro and trifluorocarbon; Y is a member selected from the group consisting of oxygen and sulfur; R1 is a member selected from the group consisting of hydrogen, alkyl, arylalkyl, and CONHR' where R' is selected from the group consisting of hydrogen, alkyl, arylalkyl and aryl; R2 and R3 are the same or different from each other and independently represent a member selected from the group consisting of hydrogen, alkyl, arylalkyl, and cycloalkyl, or R2 and R3 may form a 5 to 7-membered ring together with the nitrogen atom to which they are bonded; R4 is a member selected from the group consisting of hydrogen or lower alkyl; and nontoxic pharmacologically acceptable salts thereof. Compounds are useful in the treatment of central nervous system disorders, including depression.