2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrobromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrobromide
• 化学式: C27H39BrN2O4
• 分子量: 535.5
• InChiKey: GDVVNGBJRRJELK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.67
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  64
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Pharmacologic drug combination in vagal-induced asystole
  申请人：Emory University

  公开号：EP1555019A1

  公开（公告）日：2005-07-20

  Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administratiom of a combination of drugs.

  在对跳动的心脏进行冠状动脉搭桥手术和其他心脏手术时，有控制地停止心脏跳动可提高手术技术，通常是通过对迷走神经的电刺激和联合用药来实现的。
• Methods of performing vagal-induced asystole
  申请人：——

  公开号：US20020183237A1

  公开（公告）日：2002-12-05

  A method for indirectly stimulating a vagus nerve of a patient includes the steps of positioning one or more electrodes in the vicinity of the vagus nerve and then actuating the electrode(s) to create an electrical field for stimulating the vagus nerve. Disclosed embodiments include positioning one or more electrodes in the esophagus, trachea, or jugular vein, on the neck of the patient, and combinations thereof.

  间接刺激患者迷走神经的方法包括以下步骤：将一个或多个电极放置在迷走神经附近，然后驱动电极以产生刺激迷走神经的电场。公开的实施方案包括将一个或多个电极放置在患者颈部的食道、气管或颈静脉中，以及它们的组合。
• Methods of indirectly stimulating the vagus nerve with an electrical field
  申请人：——

  公开号：US20020198571A1

  公开（公告）日：2002-12-26

  A method for indirectly stimulating a vagus nerve of a patient includes the steps of positioning one or more electrodes in the vicinity of the vagus nerve and then actuating the electrode(s) to create an electrical field for stimulating the vagus nerve. Disclosed embodiments include positioning one or more electrodes in the esophagus, trachea, or jugular vein, on the neck of the patient, and combinations thereof.

  间接刺激患者迷走神经的方法包括以下步骤：将一个或多个电极放置在迷走神经附近，然后驱动电极以产生刺激迷走神经的电场。公开的实施方案包括将一个或多个电极放置在患者颈部的食道、气管或颈静脉中，以及它们的组合。
• Apparatus for indirectly stimulating the vagus nerve with an electrical field
  申请人：——

  公开号：US20020198570A1

  公开（公告）日：2002-12-26

  An apparatus for indirectly stimulating a vagus nerve of a patient includes electrodes positioned within the esophagus, trachea, or a jugular vein of a patient, on the neck of the patient, or in combinations of these locations. The apparatus further includes a means for actuating the electrodes to create an electrical field for stimulating the vagus nerve.

  一种用于间接刺激患者迷走神经的设备包括放置在患者食道、气管或颈静脉内、患者颈部或这些位置组合中的电极。该装置还包括用于驱动电极以产生电场刺激迷走神经的装置。
• PHARMACOLOGIC DRUG COMBINATION IN VAGAL-INDUCED ASYSTOLE
  申请人：EMORY UNIVERSITY

  公开号：EP1005337A1

  公开（公告）日：2000-06-07