(E)-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolyl-acetonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolyl-acetonitrile
• 英文别名: (2E)-2-[(4R)-4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile
• 化学式: C₁₄H₁₀ClN₃S₂
• 分子量: 319.8
• InChiKey: ZRTQSJFIDWNVJW-REQDGWNSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  92.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• ANTIFUNGAL AGENT, COMPOUND THEREFOR, PROCESS FOR PRODUCING THE SAME
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：EP0839035A2

  公开（公告）日：1998-05-06
• JPH10158168A
  申请人：——

  公开号：JPH10158168A

  公开（公告）日：1998-06-16
• ANTIFUNGAL COMPOSITION
  申请人：Masuda Takaaki

  公开号：US20100173965A1

  公开（公告）日：2010-07-08

  Disclosed is a pharmaceutical composition for antifungal use, comprising: 1) one or more compounds selected from compounds represented by the general formula (1) below and physiologically acceptable salts thereof; 2) one or more compounds selected from polypropylene glycol, diesters of dibasic acids, triacetin, 2-ethyl-1,3-hexanediol, lauromacrogol, and polyoxyethylene-polyoxypropylene glycol; and 3) one or more compounds selected from glucono-δ-lactone, propylene glycol, glycerin, and lactic acid. General formula (1) (In the formula, X represents a halogen or hydrogen). wherein X represents a halogen or hydrogen.
• US9968591B2
  申请人：——

  公开号：US9968591B2

  公开（公告）日：2018-05-15
• [EN] ANTIFUNGAL AGENT, COMPOUND THEREFOR, PROCESS FOR PRODUCING THE SAME<br/>[FR] AGENT ANTIFONGIQUE, SON COMPOSE, SON PROCEDE DE PRODUCTION
  申请人：——

  公开号：WO1997002821A2

  公开（公告）日：1997-01-30

  [EN] R-(+)-(E)-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylacetonitrile, R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylacetonitrile, and pharmaceutically acceptable salts thereof which can be used as a pharmaceutical agent are disclosed. A process for producing them and a method for treating mycoses using them are also disclosed.
  [FR] R-(+)-(E)-[4-(2-chlorophényl)-1,3-dithiolane-2-ylidène]-1-imidazolylacétonitrile, R-(-)-(E)-[4-(2,4-dichlorophényl)-1,3-dithiolane-2-ydilène]-1-imidazolylacétonitrile et les sels pharmaceutiquement acceptables de cet agent antifongique peuvent être utilisés comme agent pharmaceutique. L'invention se rapporte en outre à son procédé de production et à un procédé de traitement des mycoses utilisant cet agent antifongique.
  [EN] R-(+)-(E)-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile, R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazoly lacetonitrile, and pharmaceutically acceptable salts thereof which can be used as a pharmaceutical agent are disclosed. A process for producing them and a method for treating mycoses using them are also disclosed.