3-Nitrooxypropyl 2-(3-benzoylphenyl)propanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Nitrooxypropyl 2-(3-benzoylphenyl)propanoate
• 化学式: C19H19NO6
• 分子量: 357.4
• InChiKey: CLFSHUKVMLTNAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  98.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Non-donating nsaids adsorbed into carrier particles
  申请人：Morein Sven

  公开号：US20050129774A1

  公开（公告）日：2005-06-16

  The present invention relates to porous particles comprising one or more NO-donating Non Steroidal Antiinflammatory Compound(s) optionally mixed with one or more surfactant(s) and to new solid drug delivery composition comprising said particles optionally in combination with a second active drug. Futhermore, the invention relates to processes for producing said porous particles and solid drug delivery composition as well as the use of said composition in the manufacturing of a medicament. The No-donating NSAID may be in oily or melted form.

  本发明涉及由一种或多种NO供体非甾体抗炎化合物（可选择与一种或多种表面活性剂混合）组成的多孔颗粒，以及由所述颗粒（可选择与第二种活性药物结合）组成的新型固体给药组合物。此外，本发明还涉及生产所述多孔微粒和固体给药组合物的工艺，以及所述组合物在药品生产中的用途。无捐献非甾体抗炎药可以是油状或熔融状。
• NO-DONATING NSAIDS ADSORBED INTO CARRIER PARTICLES
  申请人：Nicox S.A.

  公开号：EP1490033A1

  公开（公告）日：2004-12-29
• PHARMACEUTICAL FORMULATION OF NITROOXYDERIVATIVES OF NSAIDS
  申请人：Gasslander Ulla

  公开号：US20090203759A1

  公开（公告）日：2009-08-13

  The present invention relates to a pharmaceutical formulation comprising: a) one or more NO-releasing NSAID(s) of formula (I); b) one or more surfactants; c) a carbonyl scavenger compound selected from free acid forms, salts, carboxylic acid esters derivatives of a compound of formula (II) H 2 N—(CH 2 ) m —(C 6 H 4 )—COOH  (II) wherein m=0-10; and d) optionally an oil or semi-solid fat and/or a short-chain alcohol.
• US8691869B2
  申请人：——

  公开号：US8691869B2

  公开（公告）日：2014-04-08
• [EN] NO-DONATING NSAIDS ADSORBED INTO CARRIER PARTICLES<br/>[FR] NSAID DONNEURS DE NO ADSORBES DANS DES PARTICULES PORTEUSES
  申请人：ASTRAZENECA AB

  公开号：WO2003080029A1

  公开（公告）日：2003-10-02

  The present invention relates to porous particles comprising one or more NO-donating Non Steroidal Antiinflammatory Compound(s) optionally mixed with one or more surfactant(s) and to new solid drug delivery composition comprising said particles optionally in combination with a second active drug. Futhermore, the invention relates to processes for producing said porous particles and solid drug delivery composition as well as the use of said composition in the manufacturing of a medicament. The No-donating NSAID may be in oily or melted form.