N-(Cyclohexylmethyl)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxybenzamide | 326922-18-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(Cyclohexylmethyl)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxybenzamide
• 英文别名: N-(cyclohexylmethyl)-5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]-2-methoxybenzamide
• CAS: 326922-18-3
• 化学式: C₁₉H₂₄N₂O₄S
• 分子量: 376.477
• InChiKey: FYGBAEFYJROARR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES
  申请人：KYORIN PHARMACEUTICAL CO., LTD.

  公开号：EP1207156B1

  公开（公告）日：2005-05-18
• US6545026B1
  申请人：——

  公开号：US6545026B1

  公开（公告）日：2003-04-08
• [EN] NOVEL STABLE CRYSTAL OF BENZYLTHIAZOLIDINEDIONE DERIVATIVE AND METHOD FOR PREPARATION THEREOF<br/>[FR] NOUVEAU CRISTAL STABLE DE DERIVE DE BENZYLTHIAZOLIDINEDIONE ET PROCEDE DE PREPARATION DE CELUI-CI
  申请人：KYORIN SEIYAKU KK

  公开号：WO2003062214A1

  公开（公告）日：2003-07-31

  Novel two types of N-cyclohexylmethyl-5-(2,4-dioxothiazolidine-5-yl)methyl-2-methoxybenzamide crystal (compound 1), characterized in that they exhibit, in X-ray powder diffraction, respective characteristic diffraction patterns at 2θ (diffraction angle) = 6.52˚, 22.2˚ and 24.0˚ (crystal A) and 2θ (diffraction angle) = 10.9˚, 20.3˚ and 23.2˚ (crystal B), and also exhibit respective single endothermic peaks in the thermal analysis (DTA); and a method for preparing the novel two types of crystal which comprises recrystallizing from solvents suitable for respective types of crystal. The novel two types of crystal of the compound 1 are uniform and are excellent in stability and thus can be advantageously used for producing the compound 1 on a commercial scale.
• [EN] SODIUM SALT OF BENZYL THIAZOLIDINE-2,4-DIONE DERIVATIVE AND HYDRATE THEREOF<br/>[FR] SEL DE SODIUM D'UN DERIVE BENZYL THIAZOLIDINE-2,4-DIONE ET HYDRATE DE SEL DE SODIUM
  申请人：KYORIN SEIYAKU KK

  公开号：WO2003050097A1

  公开（公告）日：2003-06-19

  To develop N-cyclohexyl methyl-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxybenzamide (compound (I)) which is a preventive and/or a remedy for metabolic diseases, it is needed to solve the problem of improving its dynamics in vivo, in particular, improving its absorbability in vivo. It is found out that sodium salt of the compound (I) or hydrate of the sodium salt is efficacious in improving its dynamics in vivo, in particular, improving its absorbability in vivo. Thus, there has been established an industrially advantageous method of providing the sodium salt of the compound (I) or its hydrate useful as drugs, which makes it possible to provide these compounds as drugs with high purity and good qualities.