4-[4-(2-Hydroxy-4-pyridin-3-ylbutoxy)phenyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-(2-Hydroxy-4-pyridin-3-ylbutoxy)phenyl]benzenesulfonamide
• 化学式: C₂₁H₂₂N₂O₄S
• 分子量: 398.5
• InChiKey: ZJBWFOVZNMWMTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS
  申请人：Toyokuni Tatsushi

  公开号：US20070286801A1

  公开（公告）日：2007-12-13

  This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.

  本发明提供了新颖的环氧合酶-2选择性药物，特别适用于非侵入性成像技术，如PET和SPECT的成像探针。优选的环氧合酶-2选择性药物比传统的环氧合酶-2抑制剂具有更强的效力和特异性。本发明的其他方面包括包括环氧合酶-2选择性药物的制药组合物以及检测和/或抑制环氧合酶-2的方法。这些方法特别适用于诊断和治疗疾病，如以升高的环氧合酶-2水平为特征的炎症。
• NOVEL COMPOUNDS
  申请人：AstraZeneca AB

  公开号：EP1115706A1

  公开（公告）日：2001-07-18
• US7329401B2
  申请人：——

  公开号：US7329401B2

  公开（公告）日：2008-02-12
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：ASTRA PHARMA PROD

  公开号：WO2000018730A1

  公开（公告）日：2000-04-06

  The invention relates to novel pyridyl derivatives (I), their use as medicaments, pharmaceutical formulations including them and methods for their preparation, wherein: R is hydrogen, chloro or fluoro; and N is 0, 1, or 2 or a salt or solvate thereof.
• [EN] CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS<br/>[FR] AGENTS SELECTIFS EN FAVEUR DE LA CYCLOOXYGENASE-2 UTILES EN TANT QUE SONDES D'IMAGERIE ET PROCEDES CONNEXES
  申请人：UNIV CALIFORNIA

  公开号：WO2003089013A1

  公开（公告）日：2003-10-30

  This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.