2-(3-amino-3-phenylpropylamino)-5-(3-fluorophenyl)-4-(4-pyridinyl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3-amino-3-phenylpropylamino)-5-(3-fluorophenyl)-4-(4-pyridinyl)pyridine
• 英文别名: N'-[5-(3-fluorophenyl)-4-pyridin-4-ylpyridin-2-yl]-1-phenylpropane-1,3-diamine
• 化学式: C₂₅H₂₃FN₄
• 分子量: 398.483
• InChiKey: PCZGKRDUOHHMOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE
  申请人：Amgen Inc.

  公开号：EP1042293A1

  公开（公告）日：2000-10-11
• US6174901B1
  申请人：——

  公开号：US6174901B1

  公开（公告）日：2001-01-16
• [EN] SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE<br/>[FR] COMPOSE DE PYRIDINE ET DE PYRIDAZINE SUBSTITUEES ET LEURS UTILISATIONS PHARMACEUTIQUES
  申请人：AMGEN INC

  公开号：WO1999032448A1

  公开（公告）日：1999-07-01

  Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.