[(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-[hydroxy(phosphonooxy)phosphoryl]oxy-1-phenylbutan-2-yl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-[hydroxy(phosphonooxy)phosphoryl]oxy-1-phenylbutan-2-yl]carbamate
• 化学式: C₂₅H₃₇N₃O₁₂P₂S
• 分子量: 665.6
• InChiKey: CGIPAYSHXVEANB-OEMFJLHTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  43
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  233
• 氢给体数：
  5
• 氢受体数：
  14

文献信息

• [EN] DERIVATIVES OF (3S) TETRAHYDRO-3-FURANYL (1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-(PHOSPHONOOXY)PROPYLCARBAMATE<br/>[FR] DERIVES DE (3S) TETRAHYDRO-3-FURANYL (1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-(PHOSPHONO-OXY)PROPYLCARBAMATE
  申请人：GLAXO GROUP LTD

  公开号：WO2001000635A2

  公开（公告）日：2001-01-04

  The invention relates to derivatives of (3S) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy) propylcarbamate, to processes for their preparation, and to their use as analytical markers and in the treatment of diseases caused by retroviruses.