2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline Hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline Hydrochloride
• 英文别名: 5-ethyl-2-methyl-4,4-diphenyl-2,3-dihydropyrrole;hydrochloride
• 化学式: C19H22ClN
• 分子量: 299.8
• InChiKey: RFWQAFWWZQGUQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.04
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  12.4
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Use of methadone metabolites for treatment of anxiety and depression
  申请人：Georgetown University

  公开号：US10709685B2

  公开（公告）日：2020-07-14

  Disclosed are methods of treating anxiety or depression, comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and pharmaceutically acceptable salts thereof.

  公开了治疗焦虑症或抑郁症的方法，包括向有需要的受试者施用治疗有效量的化合物，该化合物选自由 2-乙基-5-甲基-3,3-二苯基-1-吡咯啉（EMDP）、2-亚乙基-1,5-二甲基-3,3-二苯基吡咯烷（EDDP）及其药学上可接受的盐组成的组。
• PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN
  申请人：Board Of Regents Of the University Of Texas System

  公开号：EP3468540A1

  公开（公告）日：2019-04-17
• Analgesics and methods of use
  申请人：Smith-Carliss Richard

  公开号：US20070129434A1

  公开（公告）日：2007-06-07

  A method for inducing analgesia and/or inhibiting abuse of abusive substances includes administration of d-methadone metabolites or their structural analogs. The d-methadone metabolites, EMDP and EDDP, and their structural analogs may be incorporated into a suitable pharmaceutical composition for administration to patients. The invention includes the method itself, certain structural analogs, and pharmaceutical compositions for use in accordance with the method.
• USE OF METHADONE METABOLITES FOR TREATMENT OF ANXIETY AND DEPRESSION
  申请人：Georgetown University

  公开号：US20180169065A1

  公开（公告）日：2018-06-21

  Disclosed are methods of treating anxiety or depression, comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and pharmaceutically acceptable salts thereof.
• [EN] USE OF METHADONE METABOLITES FOR TREATMENT OF ANXIETY AND DEPRESSION<br/>[FR] UTILISATION DE MÉTABOLITES DE LA MÉTHADONE POUR LE TRAITEMENT DE L'ANXIÉTÉ ET DE LA DÉPRESSION
  申请人：UNIV GEORGETOWN

  公开号：WO2016191763A2

  公开（公告）日：2016-12-01