4-[(E)-2-(3-cyclopentyloxy-4-methoxyphenyl)-1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pyridine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(E)-2-(3-cyclopentyloxy-4-methoxyphenyl)-1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pyridine
• 化学式: C₂₆H₂₇NO₃S
• 分子量: 433.571
• InChiKey: SFKIYQWYVCVJEQ-BNMUCDHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  67.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-[(E)-2-(3-cyclopentyloxy-4-methoxyphenyl)-1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pyridine 、 alkaline earth salt of/the/ methylsulfuric acid 在 bis(acetylacetonate)nickel(II) 、 锌 作用下， 生成 4-[(2R)-2-(3-环戊基氧基-4-甲氧基苯基)-2-苯基乙基]吡啶 、 S-(-)-4-[2-(3-cyclopentyloxy-4-methoxyphenyl)-2-phenylethyl] pyridine
  参考文献：
  名称：

  Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

  摘要：

  Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)(2) or Cl2Ni(PPh3)(2) catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac), as the catalyst, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(97)10217-4

文献信息

• Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors
  作者：Ioannis N. Houpis、Jaemoon Lee、Ilias Dorziotis、Audrey Molina、Bob Reamer、R.P. Volante、Paul J. Reider

  DOI：10.1016/s0040-4020(97)10217-4

  日期：1998.2

  Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)(2) or Cl2Ni(PPh3)(2) catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac), as the catalyst, (C) 1998 Elsevier Science Ltd. All rights reserved.