4-[[3-[(4-Cyanophenyl)methyl]imidazol-4-yl]methyl]-1-phenylmethoxycarbonylpiperazine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[3-[(4-Cyanophenyl)methyl]imidazol-4-yl]methyl]-1-phenylmethoxycarbonylpiperazine-2-carboxylic acid
• 化学式: C₂₅H₂₅N₅O₄
• 分子量: 459.5
• InChiKey: YDZCMPMTXAGYIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• EP1165082A4
  申请人：——

  公开号：EP1165082A4

  公开（公告）日：2002-06-12
• INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
  申请人：Merck & Co., Inc.

  公开号：EP1165082A1

  公开（公告）日：2002-01-02
• Methods for the treatment of synucleinopathies
  申请人：Lansbury T. Peter

  公开号：US20070293539A1

  公开（公告）日：2007-12-20

  Methods are provided of treating synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease and Multiple System Atrophy, comprising administering to a synucleinopathic subject a farnesyl transferase inhibitor compound.
• US6358956B1
  申请人：——

  公开号：US6358956B1

  公开（公告）日：2002-03-19
• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE LA PRENYLE-PROTEINE TRANSFERASE
  申请人：MERCK & CO INC

  公开号：WO2000051611A1

  公开（公告）日：2000-09-08

  The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.