13-Butyl-oxacyclotridecan-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: 13-Butyl-oxacyclotridecan-2-one
• 化学式: C₁₆H₃₀O₂
• 分子量: 254.41
• InChiKey: WCZCQLYYFMWDGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Anticancer agents, perfumes or foods and drinks containing omega-hydroxyfatty acids
  申请人：——

  公开号：US20030055105A1

  公开（公告）日：2003-03-20

  The present invention relates to drugs and, particularly, to anticancer agents. More particularly, the present invention relates to an anticancer agents containing, as an active ingredient, at least one compound selected from the group consisting of &ohgr;-hydroxy fatty acids and salts or esters thereof, hydroxy oxo-fatty acids and salts or esters thereof, lactones, macrocyclic ketones, and macrocyclic diesters having specific chemical structures. With respect to the compounds described above used in the present invention, since the activities of killing cancer and inhibiting cancer metastasis are significantly high, the effects of preventing the recurrence of cancer and preventing cancer are exhibited, the cytotoxicity is significantly low, and a small dose is effective, it is possible to provide anticancer agents having significantly decreased side effects. Additionally, use in combination with known antitumor agents can further enhance the activity of inhibiting cancer metastasis. Among the anticancer agents of the present invention, &ohgr;-hydroxy fatty acids can be easily obtained in high purities by hydrolyzing lactones which are also the anticancer agents of the present invention.

  本发明涉及药物，特别是抗癌剂。更具体地说，本发明涉及一种抗癌剂，其含有至少一种从以下化合物组合中选择的活性成分，包括ω-羟基脂肪酸及其盐或酯、羟基酮脂肪酸及其盐或酯、内酯、大环酮和具有特定化学结构的大环二酯。对于本发明中所述的上述化合物，由于其杀灭癌细胞和抑制癌转移的活性显著高，具有预防癌症复发和预防癌症的效果，细胞毒性显著低，且小剂量就能发挥作用，因此能够提供具有显著降低副作用的抗癌剂。此外，与已知的抗肿瘤药物结合使用可以进一步增强抑制癌转移的活性。在本发明的抗癌剂中，ω-羟基脂肪酸可以通过水解也是本发明的抗癌剂的内酯轻松获得高纯度。
• PROCESS FOR PREPARING A POLYESTER
  申请人：van der Meulen Inge

  公开号：US20120136134A1

  公开（公告）日：2012-05-31

  Disclosed is a process for preparing a polyester or copolymer containing ester functionalities. The process can comprise: providing an optionally substituted lactone having a ring size of from 6 to 40 carbon atoms; and subjecting said lactone to metal mediated ring-opening polymerization using as catalyst a compound according to general formula (I): wherein M can be Al, Cr, Mn and Co; X and X′ are independently a heteroatom; Y and Y′ can be, independently, selected from O, N, S, P, C, Si, and B; Z can be selected from hydrogen, borohydrides, aluminum hydrides, carbyls, silyls, hydroxide, alkoxides, aryloxides, carboxylates, carbonates, carbamates, amidos, thiolates, phosphides, and halides; L 1 and L 2 can be independently an organic ligand linking X and Y together and linking X′ and Y′ together, respectively; and L 3 is an optional organic ligand linking Y and Y′ together.

  本发明揭示了一种制备含酯官能团的聚酯或共聚物的方法。该方法可以包括：提供一个环大小为6到40个碳原子的可选取代内酯；将所述内酯经过金属介导的开环聚合反应，使用通式（I）所述的化合物作为催化剂：其中，M可以是Al、Cr、Mn和Co；X和X'是独立的杂原子；Y和Y'可以独立地选自O、N、S、P、C、Si和B；Z可以选自氢、硼氢化物、铝氢化物、卡宾基、硅基、氢氧化物、烷氧基、芳氧基、羧酸盐、碳酸盐、氨基甲酸盐、硫酸盐、磷化物和卤化物；L1和L2可以独立地是有机配体，将X和Y连接在一起，将X'和Y'连接在一起；L3是可选的有机配体，将Y和Y'连接在一起。
• Method for Preparing Urethane (Meth)Acrylates
  申请人：BASF SE

  公开号：US20160090485A1

  公开（公告）日：2016-03-31

  Described is a process for preparing urethane (meth)acrylates. In a first step, a hydroxyalkyl (meth)acrylate (A) is reacted with a lactone (B) in the presence of at least one catalyst (C), selected from the group consisting of iron compounds, titanium compounds, aluminum compounds, zirconium compounds, manganese compounds, nickel compounds, zinc compounds, cobalt compounds, and bismuth compounds to provide a product; and, in a further step, the product is reacted with a polyisocyanate (D) which comprises at least one hydroxyalkyl (meth)acrylate bonded via an allophanate group.

  描述了一种制备脲（甲基）丙烯酸酯的过程。在第一步中，通过在至少一个催化剂（C）的存在下，将羟基烷基（甲基）丙烯酸酯（A）与内酯（B）反应，所述催化剂选自铁化合物、钛化合物、铝化合物、锆化合物、锰化合物、镍化合物、锌化合物、钴化合物和铋化合物组成的群体，以提供产物；在进一步的步骤中，将产物与至少含有通过异氰酸酯基团连接的羟基烷基（甲基）丙烯酸酯的多异氰酸酯（D）反应。
• METHOD FOR PREPARING URETHANE (METH)ACRYLATES
  申请人：BASF SE

  公开号：US20160107987A1

  公开（公告）日：2016-04-21

  Described is a process for preparing urethane (meth)acrylates. In a first step, a hydroxyalkyl (meth)acrylate is reacted with a lactone (B) in the presence of at least one zinc compound and/or bismuth compound (C) to produce a bismuth-containing product, and, in a further step, the bismuth-containing product is reacted with at least one cycloaliphatic or asymmetric aliphatic diisocyanate (D).

  描述了一种制备聚氨酯（甲基）丙烯酸酯的过程。首先，在至少一种锌化合物和/或铋化合物（C）的存在下，将羟基烷基（甲基）丙烯酸酯与内酯（B）反应，以产生含铋的产物。其次，在进一步的步骤中，将含铋的产物与至少一种环状脂肪族或非对称脂肪族二异氰酸酯（D）反应。
• ANTICANCER AGENTS, PERFUMES OR FOODS AND DRINKS CONTAINING $g(v)-HYDROXYFATTY ACIDS
  申请人：SODA AROMATIC COMPANY, LIMITED

  公开号：EP1249236A1

  公开（公告）日：2002-10-16

  The present invention relates to drugs and, particularly, to anticancer agents. More particularly, the present invention relates to an anticancer agents containing, as an active ingredient, at least one compound selected from the group consisting of ω-hydroxy fatty acids and salts or esters thereof, hydroxy oxo-fatty acids and salts or esters thereof, lactones, macrocyclic ketones, and macrocyclic diesters having specific chemical structures. With respect to the compounds described above used in the present invention, since the activities of killing cancer and inhibiting cancer metastasis are significantly high, the effects of preventing the recurrence of cancer and preventing cancer are exhibited, the cytotoxicity is significantly low, and a small dose is effective, it is possible to provide anticancer agents having significantly decreased side effects. Additionally, use in combination with known antitumor agents can further enhance the activity of inhibiting cancer metastasis. Among the anticancer agents of the present invention, ω-hydroxy fatty acids can be easily obtained in high purities by hydrolyzing lactones which are also the anticancer agents of the present invention.

  本发明涉及药物，特别是抗癌剂。 更具体地说，本发明涉及一种抗癌剂，其中含有至少一种选自具有特定化学结构的ω-羟基脂肪酸及其盐或酯、羟基氧代脂肪酸及其盐或酯、内酯、大环酮和大环二酯组成的组的化合物作为活性成分。 对于本发明中使用的上述化合物，由于杀灭癌症和抑制癌症转移的活性显著较高，具有防止癌症复发和预防癌症的效果，细胞毒性显著较低，且小剂量即可有效，因此可以提供副作用显著降低的抗癌剂。此外，与已知的抗肿瘤药物联合使用可进一步提高抑制癌症转移的活性。在本发明的抗癌剂中，ω-羟基脂肪酸很容易通过水解内酯得到高纯度的ω-羟基脂肪酸，这些内酯也是本发明的抗癌剂。