(E)-4-methyl-6-pyrrolidin-1-yl-2-[2-(3-trifluoromethyl-phenyl)-vinyl]-pyrimidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-4-methyl-6-pyrrolidin-1-yl-2-[2-(3-trifluoromethyl-phenyl)-vinyl]-pyrimidine
• 英文别名: 4-methyl-6-pyrrolidin-1-yl-2-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]pyrimidine
• 化学式: C₁₈H₁₈F₃N₃
• 分子量: 333.356
• InChiKey: HHMWYILZARJOIU-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Pyrimidine derivatives
  申请人：——

  公开号：US20020086858A1

  公开（公告）日：2002-07-04

  Pyrimidine derivatives have been found to be useful as neuropeptide Y receptor ligands and particularly as antagonists. These pyrimidine derivatives may be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, diabetes, eating disorders, and obesity.

  嘧啶衍生物被发现可作为神经肽Y受体配体，特别是拮抗剂。这些嘧啶衍生物可用于制备药物，用于治疗或预防关节炎、糖尿病、进食障碍和肥胖症。
• PYRIMIDINE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y RECEPTOR LIGANDS
  申请人：F. Hoffman-la Roche AG

  公开号：EP1335906A1

  公开（公告）日：2003-08-20
• US6657060B2
  申请人：——

  公开号：US6657060B2

  公开（公告）日：2003-12-02
• [EN] PYRIMIDINE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y RECEPTOR LIGANDS<br/>[FR] DERIVES DE PYRIMIDINE ET LEUR UTILISATION EN TANT QUE LIGANDS DE RECEPTEUR DU NEUROPEPTIDE Y
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002038551A1

  公开（公告）日：2002-05-16

  Compounds of Formula (I), as well as pharmaceutically usable salts and esters thereof, wherein R?1, R2, R3, R4, A?1 and A2¿ have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, diabetes, eating disorders and obesity.