N-(1-diphenyloxophosphinyl-1-methyl)methyl-N-methyl benzamide | 144175-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-diphenyloxophosphinyl-1-methyl)methyl-N-methyl benzamide
• 英文别名: N-(1-diphenylphosphorylethyl)-N-methylbenzamide
• CAS: 144175-34-8
• 化学式: C₂₂H₂₂NO₂P
• 分子量: 363.396
• InChiKey: JTGSIOLTRFKOPS-UHFFFAOYSA-N

物化性质

• 沸点：
  510.8±33.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苯基乙氧基膦 在 lithium diisopropyl amide 作用下， 以 甲苯 为溶剂， 反应 1.5h， 生成 N-(1-diphenyloxophosphinyl-1-methyl)methyl-N-methyl benzamide
  参考文献：
  名称：

  Synthesis and Reactivity of Aliphatic and (Hetero) Aromatic N-Alkyl-N-(Diphenyloxophosphinyl) Methyl Carboxamides and Lactams

  摘要：

  A variety of aliphatic, aromatic and heteroaromatic N-alkyl-N-(diphenyloxophosphinyl)methyl carboxamides and lactams have been prepared by preliminar chloromethylation of the appropriate secondary amides and subsequent treatment with ethyl diphenylphosphinite.

  DOI：

  10.1080/00397919208019095

文献信息

• A Simple, Convenient and General Method for the Synthesis of<i>N</i>-Acylalkylaminomethyl-and<i>N</i>-Acylalkylamino(alkyl, aryl, heteroaryl)methylphosphonates and -phosphine Oxides
  作者：Axel Couture、Eric Deniau、Pierre Grandclaudon

  DOI：10.1055/s-1994-25612

  日期：——

  A variety of N-acylalkylaminomethyl- and alkylamino(alkyl, aryl, heteroaryl)methylphosphonates and -phosphine oxides has been efficiently prepared by acylation of suitable Schiff bases and subsequent treatment of the chloromethylcarboxamide intermediates with the appropriate phosphorylating agent.

  通过适当的Schiff碱的酰化反应，以及随后用适当的磷酸化试剂处理氯甲基羧酰胺中间体，高效制备了多种N-酰基烷基氨基甲基和烷基氨基（烷基、芳基、杂芳基）甲基磷酸酯和磷酸氧化物。
• Synthesis and Reactivity of Aliphatic and (Hetero) Aromatic N-Alkyl-N-(Diphenyloxophosphinyl) Methyl Carboxamides and Lactams
  作者：Axel Couture、Eric Deniau、Pierre Grandclaudon

  DOI：10.1080/00397919208019095

  日期：1992.8

  A variety of aliphatic, aromatic and heteroaromatic N-alkyl-N-(diphenyloxophosphinyl)methyl carboxamides and lactams have been prepared by preliminar chloromethylation of the appropriate secondary amides and subsequent treatment with ethyl diphenylphosphinite.