2-(4-(3,6-dichloropyridazin-4-yl)piperazin-1-yl)ethanol | 921769-61-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-(3,6-dichloropyridazin-4-yl)piperazin-1-yl)ethanol
• 英文别名: 2-[4-(3,6-Dichloropyridazin-4-yl)-piperazin-1-yl]-ethanol；2-[4-(3,6-dichloropyridazin-4-yl)piperazin-1-yl]ethanol
• CAS: 921769-61-1
• 化学式: C₁₀H₁₄Cl₂N₄O
• 分子量: 277.153
• InChiKey: GTWQYUKLIRGCGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  52.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(4-(3,6-dichloropyridazin-4-yl)piperazin-1-yl)ethanol 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 以32.9%的产率得到4-{2-[4-(3,6-dichloropyridazin-4-yl)-piperazin-1-yl]-ethoxy}-phenylacetic acid methyl ester
  参考文献：
  名称：

  PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS

  摘要：

  公开号：

  EP1900735B1
• 作为产物：
  描述：

  N-羟乙基哌嗪 、 3,4,6-三氯哒嗪 在 sodium carbonate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 以73.6%的产率得到2-(4-(3,6-dichloropyridazin-4-yl)piperazin-1-yl)ethanol
  参考文献：
  名称：

  PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS

  摘要：

  公开号：

  EP1900735B1

文献信息

• Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors
  申请人：Li Song

  公开号：US20080269232A1

  公开（公告）日：2008-10-30

  The present invention relates to substituted pyridazinylamine derivatives of the formula I or pharmaceutically acceptable salts or hydrates thereof, wherein the substituents are defined as in the description, their preparation process, pharmaceutical compositions comprising them, and uses of the said compounds as picorna virus inhibitors for prevention and/or treatment of diseases caused by picorna viruses.

  本发明涉及式I的取代吡啶嗪胺衍生物或其药学上可接受的盐或水合物，其中取代基如描述中所定义，它们的制备过程，含有它们的药物组合物，以及作为小肠病毒抑制剂用于预防和/或治疗由小肠病毒引起的疾病的所述化合物的用途。
• Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing

  公开号：US08076339B2

  公开（公告）日：2011-12-13

  The present invention relates to substituted pyridazinylamine derivatives of the formula I or pharmaceutically acceptable salts or hydrates thereof, wherein the substituents are defined as in the description, their preparation process, pharmaceutical compositions comprising them, and uses of the said compounds as picorna virus inhibitors for prevention and/or treatment of diseases caused by picorna viruses.

  本发明涉及公式I或其药学上可接受的盐或水合物的取代吡啶嗪胺衍生物，其中取代基如描述中所定义，其制备过程，包含它们的制药组合物，以及将所述化合物用作抗肠病毒药物，以预防和/或治疗由肠病毒引起的疾病。
• US8076339B2
  申请人：——

  公开号：US8076339B2

  公开（公告）日：2011-12-13
• US8410105B2
  申请人：——

  公开号：US8410105B2

  公开（公告）日：2013-04-02
• Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors
  作者：Shi-Yong Fan、Zhi-Bing Zheng、Chun-Lai Mi、Xin-Bo Zhou、Hui Yan、Ze-Hui Gong、Song Li

  DOI：10.1016/j.bmc.2008.11.061

  日期：2009.1

  Human rhinovirus (HRV) is the most important etiologic agent causing common colds. No effective anti-HRV agents are currently available. In this paper we describe the synthesis and the evaluation of novel chloropyridazine derivatives (compounds 5a-g) as potent human rhinovirus (HRV) capsid-binding inhibitors. Results showed that compound 5e and 5f exhibited effective anti-HRV activity against HRV-2 and HRV-14. In addition, compound 5e and 5f showed lower cytotoxicity than Pirodavir. (C) 2008 Elsevier Ltd. All rights reserved.