N-3chlorophenylcarbamate | 19654-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-3chlorophenylcarbamate
• 英文别名: m-chlorophenylcarbamate；Carbamidsaeure-<3-chlor-phenylester>；3-Chlorphenylcarbamat；3-Chlorophenyl carbamate；(3-chlorophenyl) carbamate
• CAS: 19654-61-6
• 化学式: C₇H₆ClNO₂
• 分子量: 171.583
• InChiKey: SHXGGYLLZCCNAX-UHFFFAOYSA-N

物化性质

• 熔点：
  135-137 °C
• 沸点：
  319.3±34.0 °C(Predicted)
• 密度：
  1.359±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-chloro-3-cyanato-benzene 在 苯甲酸 作用下， 以 苯 为溶剂， 生成 N-3chlorophenylcarbamate
  参考文献：
  名称：

  Grigat,E.; Puetter,R., Chemische Berichte, 1965, vol. 98, p. 1359 - 1364

  摘要：

  DOI：

文献信息

• [EN] TRISUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AS CDK7 INHIBITORS<br/>[FR] COMPOSÉS PYRAZOLO[1,5-A] PYRIMIDINE TRISUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE CDK7
  申请人：TRANSLATIONAL GENOMICS RES INST

  公开号：WO2020186196A1

  公开（公告）日：2020-09-17

  Compounds having activity as cancer agents are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salts, stereoisomers, tautomers, thereof, wherein R1, R2, R3 and L are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating a CDK7-dependent disease (e.g., cancer).

  提供具有作为抗癌剂活性的化合物。这些化合物具有以下结构（I）或其药用可接受的盐、立体异构体、互变异构体，其中R1、R2、R3和L如本文所定义。本公开提供了与制备和使用这些化合物相关的方法，包括含有这些化合物的药物组合物，以及治疗CDK7依赖性疾病（例如癌症）的方法。
• N-phosphonomethylglycine derivatives
  申请人：Geshuri Laboratories Ltd.

  公开号：EP0088180A1

  公开（公告）日：1983-09-14

  The invention provides N-Phosphonomethylglycine derivatives of the general formula I wherein R,, R2 and R3 are independently selected from-OH and -OR4 wherein R4 is a salt forming cation iminourea derivative of the general formula II wherein R5, R5, R6, R6, and R7 are independently H, NH2, or an aryl, cycloalkyl or straight or branched chain alkyl or alkenyl group optionally substituted by hydroxy or halogen, or an alkylaryl group, provided that at least one but no more than two of R,, R2 or R3 are OR4; no more than two R5, R5, R6, R6, are aryl or substituted aryl; and no more than one of R5, R5., R6, R6, and R, is CH2OH. The invention also provides a process for preparing the above N-Phosphonomethylglycine imino urea salts as well as providing phytotoxic compositions containing the same.

  本发明提供通式 I 的 N-膦酰甲基甘氨酸衍生物 其中 R、R2 和 R3 独立地选自-OH 和-OR4，其中 R4 是通式 II 的成盐阳离子亚氨基脲衍生物 其中R5、R5、R6、R6和R7独立地为H、NH2、 本发明还提供了制备上述N-膦酰甲基甘氨酸亚氨基脲盐以及提供含有上述N-膦酰甲基甘氨酸亚氨基脲盐的植物毒性组合物的工艺。
• 1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indoles, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0253372A2

  公开（公告）日：1988-01-20

  There are described compounds of the formula where (a) X is O or S; (b) R is H, loweralkyl, where Y is O or S; R2 is loweralkyl, cycloalkyl; bicycloalkyl, cycloalkenyl, aryl, arylloweralkyl, heteroaryl or heteroarylloweralkyl, R3 is H or lower alkyl or the group -NR2R3 taken as a whole is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiomorpholinyl, 1-piperazinyl, 4-methyl-1-piperazinyl or 2-(2,6-dichlorophenyl- imino)-1-imidazolidinyl) and R4 is hydrogen, loweralkyl, arylloweralkyl, diarylloweralkyl, aryl or heteroaryl, (c) m is 1 or 2; (d) each Z is independently H, loweralkyl, halogen, nitro, -NH2, loweralkylcarbonylamino, arylcarbonylamino, loweralkoxycarbonylamino or loweralkylamino, and (e) R1 is H, loweralkyl, arylloweralkyl, heteroarylloweralkyl, cycloalkylmethyl or loweralkenylmethyl, with the proviso that when X is O, m is 1, Z is Hand R1 is methyl, R is not -CONHCH3, -CONHC6H5, hydrogen, methyl or ethyl, and that when X is O, m is 1 and Z and R1 are both hydrogen, R is not hydrogen or methyl, and pharmaceutically acceptable acid addition salts thereof which are useful as memory-enhancing and analgesic agents.

  所述化合物的化学式为 式中 (a) X 是 O 或 S； (b) R 是 H、低级烷基、 其中 Y 是 O 或 S；R2 是低级烷基、环烷基、双环烷基、环烯基、芳基、芳基低级烷基；(b) R 是 H、低级烷基，其中 Y 是 O 或 S；R2 是低级烷基、环烷基、双环烷基、环烯基、芳基、芳低级烷基、杂芳基或杂芳基低级烷基；R3 是 H 或低级烷基，或整个基团 -NR2R3 是 1-吡咯烷基、1-哌啶基、4-吗啉基、4-硫代吗啉基、1-吡咯烷基、1-哌啶基、4-吗啉基4-硫代吗啉基、1-哌嗪基、4-甲基-1-哌嗪基或 2-(2,6-二氯苯基-亚氨基)-1-咪唑烷基），R4 是氢、低级烷基、芳低级烷基、二芳低级烷基、芳基或杂芳基、 (c) m 是 1 或 2； (d) 每个 Z 独立地为 H、低级烷基、卤素、硝基、-NH2、低级烷基羰基氨基、芳基羰基氨基、低级烷氧基羰基氨基或低级烷基氨基，以及 (e) R1 是 H、低级烷基、芳基低级烷基、杂芳基低级烷基、环烷基甲基或低级烯基甲基、 但条件是当 X 为 O、m 为 1、Z 为手 R1 为甲基时，R 不是-CONHCH3、-CONHC6H5、氢、甲基或乙基；当 X 为 O、m 为 1 且 Z 和 R1 均为氢时，R 不是氢或甲基；以及其药学上可接受的酸加成盐，可用作增强记忆和镇痛剂。
• Pyrrolotriazole derivative
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0518238A1

  公开（公告）日：1992-12-16

  A novel pyrrolotriazole derivative is disclosed, represented by any one of formulae (I), (II), or (III): wherein:    R¹, R², R³ and R⁴ each independently represents a hydrogen atom or a nonmetallic atomic group;    R⁵ and R⁶ each independently represents a hydrogen atom, alkyl group, an aryl group, or a heterocyclic group;    R⁷ represents an electrophilic group having a Hammett's substituent constant σp of 0.15 or more;    R⁸ and R⁹ each independently represents a hydrogen atom or a nonmetallic atomic group;    the sum of Hammett's substituent constant σp of R⁷ and R⁸ is 0.65 or more;    R¹ and R², and/or R² and R⁵, and/or R⁵ and R⁶, and/or R⁶ and R³, and/or R³ and R⁴ may be connected to each other to form a cyclic structure;    R⁷ and R⁸ may be connected to each other to form a cyclic structure; and    Z represents a hydrogen atom, a halogen atom, an arylthio group, a heterocyclic thio group, an arylsulfinyl group, or a nitroso group.

  本发明公开了一种新型吡咯三唑衍生物，由式（I）、（II）或（III）中的任意一个表示： 其中 R¹、R²、R³ 和 R⁴ 各自独立地代表氢原子或非金属原子团； R⁵ 和 R⁶ 各自独立地代表氢原子、烷基、芳基或杂环基团； R⁷ 代表亲电基团，其哈米特取代基常数 σp 为 0.15 或更大； R⁸ 和 R𠞙 各自独立地代表氢原子或非金属原子团； R⁷ 和 R⁸ 的哈米特取代常数 σp 之和为 0.65 或以上； R¹ 和 R²、和/或 R² 和 R⁵、和/或 R⁵ 和 R⁶、和/或 R⁶ 和 R³、和/或 R³ 和 R⁴ 可相互连接形成环状结构； R⁷ 和 R⁸ 可相互连接形成环状结构；以及 Z 代表氢原子、卤素原子、芳硫基、杂环硫基、芳基亚磺酰基或亚硝基。
• Imidazole azo dyes and thermal transfer dye donating materials containing them
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0545420A2

  公开（公告）日：1993-06-09

  Disclosed is an imidazole azo dye of formula (I), which is useful for image formation and as a filter dye, which has a sharp absorption wave and which is fast to light, heat, air, moisture and chemicals. Also disclosed is a thermal transfer dye-donating material containing imidazole azo dye(s) of formula (I) preferably along with aminopyrazole azo dye(s) of formula (II). The material gives a high-density image with good color reproduction, and the image formed has improved storage stability. In (I), B and C independently represent a hydrogen atom or a substituent capable of being substituted in the imidazole ring; A represents an aryl or heterocyclic group; provided that when B is a hydrogen atom, C is not a hydrogen atom nor an alkyl group having from 1 to 3 carbon atoms; provided that when C is a hydrogen atom, B is not a substituted nor unsubstituted alkyl group; provided that C is not a mercapto group or an alkylthio group; and provided that B is not a carboxyl group. In (II), D represents a hydrogen atom, or an alkyl, aryl, or heterocyclic group, E represents a substituent capable of being substituted in the pyrazole ring, F represents an aryl or heteroaromatic group, and G and I independently represent a hydrogen atom, or an alkyl, aryl, or heterocyclic group.

  本发明公开了一种式(I)的咪唑偶氮染料，该染料可用于形成图像和用作过滤染料，它具有尖锐的吸收波，并且对光、热、空气、湿气和化学品具有快速吸收性。本发明还公开了一种热转印染料捐赠材料，该材料最好含有式（I）的咪唑偶氮染料和式（II）的氨基吡唑偶氮染料。该材料可产生色彩再现性良好的高密度图像，所形成的图像具有更好的储存稳定性。 在（I）中，B 和 C 独立地代表氢原子或咪唑环中能够被取代的取代基；A 代表芳基或杂环基；条件是当 B 是氢原子时，C 不是氢原子或具有 1 至 3 个碳原子的烷基；条件是当 C 是氢原子时，B 不是取代或未取代的烷基；条件是 C 不是巯基或烷硫基；以及条件是 B 不是羧基。 在(II)中，D 代表氢原子或烷基、芳基或杂环基，E 代表吡唑环中可被取代的取代基，F 代表芳基或杂芳基，G 和 I 独立地代表氢原子或烷基、芳基或杂环基。