methacrylic acid-(3-chloro-phenyl ester) | 16522-38-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: methacrylic acid-(3-chloro-phenyl ester)
• 英文别名: Methacrylsaeure-(3-chlor-phenylester)；3-Chlorophenyl 2-methylprop-2-enoate；(3-chlorophenyl) 2-methylprop-2-enoate
• CAS: 16522-38-6
• 化学式: C₁₀H₉ClO₂
• 分子量: 196.633
• InChiKey: UZPZUBQNWHJPCU-UHFFFAOYSA-N

物化性质

• 沸点：
  65 °C(Press: 0.1 Torr)
• 密度：
  1.177±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲基丙烯酰氯 以87%的产率得到
  参考文献：
  名称：

  BANKS A. R.; FIBIGER R. F.; JONES T., J. ORG. CHEM., 1977, 42, NO 24, 3965-3966

  摘要：

  DOI：

文献信息

• The Reactivities of Nuclear-Substituted Phenyl Methacrylates in Radical Copolymerization with Styrene
  作者：Takayuki Otsu、Toshio Ito、Yoshihiro Fujii、Minoru Imoto

  DOI：10.1246/bcsj.41.204

  日期：1968.1

  reactivities of methacrylate monomers toward the attack of a radical, the copolymerizations of a series of nuclear-substituted phenyl methacrylates with styrene were investigated. From the results, the monomer reactivity ratios and the Alfrey-Price Q, and e values were determined. It was found that the relative reactivities toward the polystyryl radical were not correlated with the ordinary Hammett equation

  为了阐明烷基取代基对甲基丙烯酸酯单体对自由基攻击的反应性的影响，研究了一系列核取代的甲基丙烯酸苯酯与苯乙烯的共聚反应。根据结果​​，确定了单体反应性比率和 Alfrey-Price Q 和 e 值。发现对聚苯乙烯基团的相对反应性与普通的哈米特方程无关，但通过包含取​​代基共振贡献项的修正哈米特方程获得了线性关系。因此，认为取代的甲基丙烯酸苯酯的反应性取决于由取代基引起的极性和共振效应。
• Responsive microgel and methods related thereto
  申请人：——

  公开号：US20030152623A1

  公开（公告）日：2003-08-14

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.

  本发明提供了一种响应型微凝胶，该微凝胶可对选自由温度、pH 值和离子条件组成的组中的一种或多种水性条件的变化作出体积上和可逆的响应、和离子条件）组成的共价交联均聚可离子化单体的可离子化网络，其中可离子化网络与两性共聚物共价连接，形成多条 "悬链"，两性共聚物的 "悬链 "在水溶液中形成不动的胶束状聚集体。还提供了一种响应性微凝胶，它包含至少一种治疗实体，并能在生理条件下提供治疗实体的线性和持续释放。
• Some New Thiol Esters. Preparation of Dithiolfumarates
  作者：Gene Sumrell、Morris Zief、Earl J. Huber、George E. Ham、Charles H. Schramm

  DOI：10.1021/ja01525a052

  日期：1959.8
• A convenient synthesis of methacrylates
  作者：Allen R. Banks、Richard F. Fibiger、Ted Jones

  DOI：10.1021/jo00444a042

  日期：1977.11
• PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS
  申请人：G.D. Searle & Co.

  公开号：EP0907666A1

  公开（公告）日：1999-04-14