3-[(4-Methylphenoxy)methyl]benzoic acid | 195447-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(4-Methylphenoxy)methyl]benzoic acid
• CAS: 195447-86-0
• 化学式: C₁₅H₁₄O₃
• mdl: MFCD00187773
• 分子量: 242.27
• InChiKey: PKEXZXAKLARHFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Chemical inducers of neurogenesis
  申请人：Schneider Jay

  公开号：US20090036451A1

  公开（公告）日：2009-02-05

  The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

  本发明涉及化合物和方法，用于诱导正常神经干细胞和脑癌干细胞的神经元分化。这些方法可以在体外进行，例如在成年哺乳动物大脑的分离物中，或在体内进行。本文描述的化合物和方法可能在治疗神经退行性和精神疾病、神经系统的修复和再生以及神经逻辑恶性肿瘤的治疗中发挥作用。
• COMPOUNDS FOR CANCER CHEMOTHERAPEUTIC SENSITIZATION
  申请人：Regents of the University of Minnesota

  公开号：US20190240244A1

  公开（公告）日：2019-08-08

  The invention provides a compound of formula (I), (II) or (III): wherein R 1 , R 2 , R 3 , R 4 and R 5 have any of the values described in the specification, as well as compositions comprising a compound of formula (I), (II) or (III). The compounds and compositions are useful as chemotherapeutic sensitizing agents.

  本发明提供了一种公式(I)、(II)或(III)的化合物： 其中R1、R2、R3、R4和R5具有说明书中描述的任何值，以及包含公式(I)、(II)或(III)的化合物的组合物。这些化合物和组合物作为化学治疗增敏剂是有用的。
• STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR
  申请人：Olson Eric

  公开号：US20090076103A1

  公开（公告）日：2009-03-19

  The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.

  本发明涉及筛选化合物的屏幕，这些化合物可以诱导干细胞分化。此外，已确定异噁唑和磺酰肼是可以分别诱导干细胞分化为神经元和心脏细胞的通用化合物类别。
• CHEMICAL INDUCERS OF NEUROGENESIS
  申请人：Schneider Jay

  公开号：US20130143885A1

  公开（公告）日：2013-06-06

  The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

  本发明涉及化合物和方法，用于诱导正常神经干细胞和脑癌干细胞的神经元分化。这些方法可以在体外进行，例如从成年哺乳动物大脑中分离出来，也可以在体内进行。本文所描述的化合物和方法可以在神经退行性和精神疾病的治疗、神经系统的修复和再生以及神经逻辑恶性肿瘤的治疗中发挥作用。
• Compounds for cancer chemotherapeutic sensitization
  申请人：Regents of the University of Minnesota

  公开号：US10617706B2

  公开（公告）日：2020-04-14

  The invention provides a compound of formula (I), (II) or (III): wherein R1, R2, R3, R4 and R5 have any of the values described in the specification, as well as compositions comprising a compound of formula (I), (II) or (III). The compounds and compositions are useful as chemotherapeutic sensitizing agents.

  本发明提供了一种式 (I)、(II) 或 (III) 的化合物： 其中 R1、R2、R3、R4 和 R5 具有说明书中描述的任一数值，以及包含式 (I)、(II) 或 (III) 化合物的组合物。这些化合物和组合物可用作化疗增敏剂。