2-(3-甲基氨基丙基氨基)乙硫醇 | 117062-90-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(3-甲基氨基丙基氨基)乙硫醇
• 英文名称: 2-[3-(methylamino)-propylamino] ethanethiol
• 英文别名: 2-[3-(methylamino) propylamino] ethanethiol；2-[3-(methylamino)propylamino] ethanethiol；2-[3-(methylamino)propylamino]ethanethiol；S-2-(3-Methylaminopropylamino)ethanethiol
• CAS: 117062-90-5
• 化学式: C₆H₁₆N₂S
• mdl: MFCD19217997
• 分子量: 148.272
• InChiKey: XYLUJZDXASMNBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-甲基氨基丙基氨基)乙硫醇 、 4-氯苯基二氯磷酸酯 在 N-甲基咪唑 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以21%的产率得到4'-chlorophenyl bis[2-(3-methylaminopropylamino)ethyl]thiophosphate
  参考文献：
  名称：

  Synthesis and radioprotective effects of new phosphorothioate esters of WR-2721, WR-3689 and WR-151327

  摘要：

  DOI：

  10.1016/s0960-894x(97)00081-4
• 作为产物：
  描述：

  dibromohydrate du N-(bromoethyl-2)N'-(methyl)diamino-1,3 propane 在 sodium hydrogensulfide 、 硫化氢 作用下， 以 甲醇 为溶剂， 以41%的产率得到2-(3-甲基氨基丙基氨基)乙硫醇
  参考文献：
  名称：

  Synthesis and radioprotective effects of new phosphorothioate esters of WR-2721, WR-3689 and WR-151327

  摘要：

  DOI：

  10.1016/s0960-894x(97)00081-4

文献信息

• Method for protection against genotoxic mutagenesis
  申请人：ARCH DEVELOPMENT CORPORATION

  公开号：EP1437139A2

  公开（公告）日：2004-07-14

  A method for protecting against mutational damage in mammalian cells induced by irradiation comprising administering a phosphorothioate or phosphorothiate metabolite selected from the group consisting S-2-(3-aminopropylamino)ethylphosphorothioic acid, S-1-(aminoethyl) phosphorothioic acid, S-[2-(3-methylaminopropyl) aminoethyl] phosphorothioate acid, S-2-(4-aminobu-lamino) ethylphosphorothioic acid, 3-[(2-mercaptoethyl) amino] propionamide p-toluenesulfonate, S-1-(2-hydroxy-3-amino) propyl phosphorothioic acid, 2-[3-(methylamino) propylamino] ethanethiol, 2-(aminopropylamino)ethanethiol, S-2-(5-aminopentylamino) ethyl phosphorothioic acid, 1 [3-(3-(aminopropyl) thiazolidin-2-Y1]-D-gluco-1,2,3,4,5 pentanepentol dihydrochloride and N,N'-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamme to the mammal before or up to 3 hours after irradiation.

  一种保护哺乳动物细胞免受辐照诱导的突变损伤的方法，包括施用一种硫代磷酸酯或硫代磷酸酯代谢物，该代谢物选自由 S-2-(3-氨基丙基氨基)乙基硫代磷酸、S-1-(氨基乙基)硫代磷酸、S-[2-(3-甲基氨基丙基)氨基乙基]硫代磷酸、S-2-(4-氨基丁氨基)乙基硫代磷酸组成的组、3-[（2-巯乙基）氨基]丙酰胺对甲苯磺酸盐、S-1-（2-羟基-3-氨基）丙基硫代磷酸、2-[3-（甲基氨基）丙基氨基]乙硫醇、2-（氨基丙基氨基）乙硫醇、S-2-（5-氨基戊基氨基）乙基硫代磷酸、1 [3-(3-(氨基丙基)噻唑烷-2-Y1]-D-葡萄糖-1,2,3,4,5 戊戊醇二盐酸盐和 N,N'-(二硫代-2,1-乙二基)双-1,3-丙二酰胺。
• Use of aminothiol compounds for the treatment xerostomia caused by therapeutic agents or radiation
  申请人：Medimmune Oncology, Inc.

  公开号：EP1537861A2

  公开（公告）日：2005-06-08

  The present invention relates to new uses of S-2(3-aminopropylamino)ethyl dihydrogen phosphorothioate (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, or radiation treatment. In particular, the invention provides a method for treating neurotoxicity and nephrotoxicity associated with the administration of chemotherapeutic agents.

  本发明涉及 S-2(3-氨丙基氨基)乙基二氢硫代磷酸酯（氨磷汀）和其他氨硫醇化合物在治疗和逆转由治疗剂或放射治疗引起的毒性方面的新用途。特别是，本发明提供了一种治疗与施用化疗药物有关的神经毒性和肾毒性的方法。
• Methods and compositions for protection of cells and tissues from computed tomography radiation
  申请人：The University of Chicago

  公开号：US10987366B2

  公开（公告）日：2021-04-27

  Described are methods for preventing or inhibiting genomic instability and in cells affected by diagnostic radiology procedures employing ionizing radiation. Embodiments include methods of preventing or inhibiting genomic instability and in cells affected by computed tomography (CT) radiation. Subjects receiving ionizing radiation may be those persons suspected of having cancer, or cancer patients having received or currently receiving cancer therapy, and or those patients having received previous ionizing radiation, including those who are approaching or have exceeded the recommended total radiation dose for a person.

  所描述的是防止或抑制基因组不稳定性和细胞受采用电离辐射的放射诊断程序影响的方法。本发明的实施方案包括防止或抑制基因组不稳定性和细胞受计算机断层扫描（CT）辐射影响的方法。接受电离辐射的受试者可以是那些怀疑患有癌症的人，或已经接受或正在接受癌症治疗的癌症患者，或以前接受过电离辐射的患者，包括那些接近或已经超过建议的个人总辐射剂量的人。
• Methods for treatment of neuro- and nephro- disorders and therapeutic toxicities using aminothiol compounds
  申请人：U.S. Bioscience, Inc.

  公开号：US20020132795A1

  公开（公告）日：2002-09-19

  The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particular, the invention provides a method for treating neurotoxicity and nephrotoxicity associated with the administration of chemotherapeutic agents.

  本发明涉及 S-2-(3-氨基丙基氨基)乙基二氢硫代磷酸酯（氨磷汀）和其他氨硫醇化合物治疗和逆转由治疗剂、放射治疗或糖尿病引起的毒性的新用途。特别是，本发明提供了一种治疗与施用化疗药物有关的神经毒性和肾毒性的方法。
• Topical administration of amifostine and related compounds
  申请人：MedImmune Oncology, Inc.

  公开号：US20030022867A1

  公开（公告）日：2003-01-30

  The present invention is directed to methods of treating or protecting mucosal tissue from damage associated with radiation and/or chemotherapeutic treatment of cancers, by the topical application of amifostine and related compounds. These methods avoid the side effects of systemically applied radio/chemo protectants. The invention is also directed to treatment and prevention of infections associated with mucositis by topical application of amifostine and related compounds.

  本发明涉及通过局部应用阿米福星和相关化合物来治疗或保护粘膜组织免受与癌症的放射治疗和/或化疗相关的损伤的方法。这些方法避免了全身应用放射/化疗保护剂的副作用。本发明还涉及通过局部应用阿米福星和相关化合物来治疗和预防与粘膜炎相关的感染。