6-bromo-2,3-dimethyl-8-(([4-(methyloxy)phenyl]methyl) oxy)imidazo[1,2-a]pyridine | 910777-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 6-bromo-2,3-dimethyl-8-(([4-(methyloxy)phenyl]methyl) oxy)imidazo[1,2-a]pyridine
• 英文别名: 6-Bromo-2,3-dimethyl-8-({[4-(methyloxy)phenyl]methyl}oxy)imidazo[1,2-a]pyridine；6-bromo-8-[(4-methoxyphenyl)methoxy]-2,3-dimethylimidazo[1,2-a]pyridine
• CAS: 910777-46-7
• 化学式: C₁₇H₁₇BrN₂O₂
• 分子量: 361.238
• InChiKey: YIXGZZZAKDGZBZ-UHFFFAOYSA-N

物化性质

• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  35.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-bromo-2,3-dimethyl-8-(([4-(methyloxy)phenyl]methyl) oxy)imidazo[1,2-a]pyridine 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 6-Bromo-2,3-dimethylimidazo[1,2-a]pyridin-8-ol
  参考文献：
  名称：

  Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs)

  摘要：

  Acid pump antagonists (APAs) such as the imidazo[1,2-a]pyridine AZD-0865 2 have proven efficacious at low oral doses in acid related gastric disorders. Herein we describe some of the broader SAR in this class of molecule and detail the discovery of an imidazo[1,2-a]pyridine 15 which has excellent efficacy in animal models of gastric acid secretion following oral administration, as well as a good overall developability pro. le. The discovery strategy focuses on use of heteroaryl and heterocyclic substituents at the C-6 position and optimization of developability characteristics through modulation of global physico-chemical properties. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.127
• 作为产物：
  描述：

  6,8-Dibromo-2,3-dimethylimidazo[1,2-a]pyridine 、 4-甲氧基苄醇 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 6-bromo-2,3-dimethyl-8-(([4-(methyloxy)phenyl]methyl) oxy)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs)

  摘要：

  Acid pump antagonists (APAs) such as the imidazo[1,2-a]pyridine AZD-0865 2 have proven efficacious at low oral doses in acid related gastric disorders. Herein we describe some of the broader SAR in this class of molecule and detail the discovery of an imidazo[1,2-a]pyridine 15 which has excellent efficacy in animal models of gastric acid secretion following oral administration, as well as a good overall developability pro. le. The discovery strategy focuses on use of heteroaryl and heterocyclic substituents at the C-6 position and optimization of developability characteristics through modulation of global physico-chemical properties. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.127

文献信息

• Derivatives of Imidazo [1,2-A] Pyridine Useful as Medicaments For Treating Gastrointestinal Diseases
  申请人：Bamford Mark James

  公开号：US20080255358A1

  公开（公告）日：2008-10-16

  Disclosed are imidazopyridine compounds having the formula:

  揭示了具有以下式子的咪唑吡啶化合物：
• IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS
  申请人：Bamford Mark James

  公开号：US20100311740A1

  公开（公告）日：2010-12-09

  This invention relates to newly identified imidazopyridine compounds of formula (I), to the use of such compounds in treating GERD and the like.

  本发明涉及公式(I)的新发现的咪唑吡啶化合物，以及使用这些化合物治疗GERD等疾病的方法。
• WO2006/100119
  申请人：——

  公开号：——

  公开（公告）日：——
• WO2007/3386
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS<br/>[FR] DÉRIVÉS D'IMIDAZOPYRIDINE AGISSANT COMME ANTAGONISTE DES POMPES SÉCRÉTANT L'ACIDE
  申请人：GLAXO GROUP LTD

  公开号：WO2007003386A1

  公开（公告）日：2007-01-11

  [EN] This invention relates to newly identified imidazopyridine compounds of formula (I), to the use of such compounds in therapy and to their production.
  [FR] L'invention concerne des composés d'imidazopyridine nouvellement identifiés selon la formule (I), leurs utilisations thérapeutiques et leur production.