2-pentyl-2,3-dihydro-1H-isoindole | 1197914-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-pentyl-2,3-dihydro-1H-isoindole
• 英文别名: 2-Pentyl-1,3-dihydroisoindole；2-pentyl-1,3-dihydroisoindole
• CAS: 1197914-56-9
• 化学式: C₁₃H₁₉N
• 分子量: 189.301
• InChiKey: KEOPAMHHEROYQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-氨基戊烷 、 1,2-二(溴甲基)苯 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以70%的产率得到2-pentyl-2,3-dihydro-1H-isoindole
  参考文献：
  名称：

  Subbarayappa, Adimurthy; Patoliya, Paresh U., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 4, p. 545 - 552

  摘要：

  DOI：

文献信息

• 10.1039/d4ob00463a
  作者：Dutta, Somnath、Eyolfson, Samantha、Zhu, Yuhang、Gao, Yuefeng、Wang, Xiang

  DOI：10.1039/d4ob00463a

  日期：——

  An efficient and practical one-pot synthesis of isoindolines from readily available starting materials was achieved under mild conditions by implementing an isoindole umpolung strategy. A variety of isoindolines were prepared with good to excellent yields. Biological screens of these identified compounds demonstrated that they are potent potentiators of colistin for multi-drug resistant Acinetobacter

  通过实施异吲哚翻转策略，在温和条件下，从容易获得的起始原料中高效实用地一锅法合成异吲哚啉。制备了多种异吲哚啉，产率良好至优异。这些已鉴定化合物的生物学筛选表明，它们是粘菌素对多重耐药鲍曼不动杆菌的有效增强剂。
• [EN] CYCLOSPORIN ANALOGUES FOR PREVENTING OR TREATING HEPATITIS C INFECTION<br/>[FR] ANALOGUES DE LA CYCLOSPORINE POUR PRÉVENIR OU TRAITER UNE INFECTION PAR L'HÉPATITE C
  申请人：ENANTA PHARM INC

  公开号：WO2010088573A1

  公开（公告）日：2010-08-05

  The present invention relates to cyclosporin analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds.
• [EN] CYCLOSPORIN ANALOGUES FOR PREVENTING OR TREATING HEPATITIS C<br/>[FR] ANALOGUES DE CYCLOSPORINE POUR PRÉVENIR OU TRAITER UNE HÉPATITE C
  申请人：ENANTA PHARM INC

  公开号：WO2015031381A1

  公开（公告）日：2015-03-05

  The present invention relates to novel cyclosporine analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporine analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds.
• Subbarayappa, Adimurthy; Patoliya, Paresh U., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 4, p. 545 - 552
  作者：Subbarayappa, Adimurthy、Patoliya, Paresh U.

  DOI：——

  日期：——