S-ethyl phosphorodichlorothioate | 1486-40-4

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机硫代磷化合物
• 英文名称: S-ethyl phosphorodichlorothioate
• 英文别名: 1-dichlorophosphorylsulfanylethane；thiophosphorodichloridic acid S-ethyl ester；dichlorothiophosphoric acid S-ethyl ester；Dichlorothiophosphorsaeure-S-aethylester；S-Aethyl-dichlorothiophosphat；ethyl phosphorodichloridothionate；Phosphorodichloridothioic acid, S-ethyl ester
• CAS: 1486-40-4
• 化学式: C₂H₅Cl₂OPS
• 分子量: 179.007
• InChiKey: NZFDAHDTWVNSSI-UHFFFAOYSA-N

物化性质

• 沸点：
  94-95 °C(Press: 17-18 Torr)
• 密度：
  1.4055 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  S-ethyl phosphorodichlorothioate 在 tetraphosphorus decasulfide 作用下， 反应 3.0h， 以30%的产率得到dithiophosphorodichloridic acid ethyl ester
  参考文献：
  名称：

  Synthesis op alkyldichlorodithiophosphates

  摘要：

  DOI：

  10.1007/bf00959898
• 作为产物：
  描述：

  二氯硫代磷酸乙酯 反应 7.0h， 生成 S-ethyl phosphorodichlorothioate
  参考文献：
  名称：

  Synthesis op alkyldichlorodithiophosphates

  摘要：

  DOI：

  10.1007/bf00959898

文献信息

• Pyridyl esters of N-alkylidene-substituted phosphor- and phosphonamidic
  申请人：Velsicol Chemical Corporation

  公开号：US04226859A1

  公开（公告）日：1980-10-07

  This invention discloses chemical compounds of the formula ##STR1## wherein X.sup.1 is selected from the group consisting of oxygen and sulfur; R.sup.1 is selected from the group consisting of hydrogen, alkyl, phenyl, alkoxy and alkylthio; R.sup.2 is selected from the group consisting of alkoxy, alkylthio, amino, alkylamino and dialkylamino; with the proviso that a maximum of one of R.sup.1 and R.sup.2 is alkoxy or alkylthio; Z is selected from the group consisting of alkyl, alkoxy, nitro and halogen; and n is an integer from 0 to 4; and wherein R.sup.3 is selected from the group consisting of alkyl, alkoxy, alkylthio and ##STR2## wherein X.sup.2 is selected from the group consisting of oxygen and sulfur; X.sup.3 is halogen; k is the integer 0 or 1; and 1 and m are each integers from 0 to 3. Further disclosed are insecticidal compositions utilizing the compound of the present invention.

  这项发明揭示了化学化合物的结构式如下：其中X.sup.1选自氧和硫的组；R.sup.1选自氢、烷基、苯基、烷氧基和烷基硫基的组；R.sup.2选自烷氧基、烷基硫基、氨基、烷基氨基和二烷基氨基的组；但R.sup.1和R.sup.2中最多只能有一个是烷氧基或烷基硫基；Z选自烷基、烷氧基、硝基和卤素的组；n是0到4之间的整数；R.sup.3选自烷基、烷氧基、烷基硫基和结构式中的部分；其中X.sup.2选自氧和硫的组；X.sup.3是卤素；k是整数0或1；l和m分别是0到3之间的整数。进一步揭示了利用本发明化合物的杀虫组合物。
• THIOPHOSPHATE NUCLEOSIDES FOR THE TREATMENT OF HCV
  申请人：IDENIX PHARMACEUTICALS, INC.

  公开号：US20140248242A1

  公开（公告）日：2014-09-04

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, the compounds are according to Formula 2001: where PD, Base, R A and R B are as provided herein. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗黄病毒科感染，包括HCV感染的化合物、组合物和方法。在某些实施例中，所述化合物符合以下公式2001： 其中PD、Base、R A 和R B 如本文所述。在某些实施例中，披露了核苷类衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• STUDIES ON CHIRAL THIOPHOSPHORIC ACIDS AND THEIR DERIV ATIVES 16.-THE ASYMMETRIC CYCLIZATION OF L-(+)- PROLINOL WITH (THIO)PHOSPHORO(-NO)DICHLORIDATES
  作者：Zheng-Jie He、You-Ming Wang、Chu-Chi Tang

  DOI：10.1080/10426509708040496

  日期：1997.8.1

  The cyclizations of L-(+)-prolinol 5 with (thio)phosphoro(-no)dichloridates 6 give 1,2,3-azaphosphaoxabicyclo[3.3.0]octanes 7 consisting of unequal amounts of diastereoisomers, eight pairs of which have been successfully resolved by silica gel column chromatography or recrystallization. The influences of reaction temperature, solvent and substrate concentration upon the asymmetric induction have also been investigated.
• 1069. The formation of phosphorus–sulphur compounds from phosphorus halides and alkylthiosilanes and silthianes
  作者：E. W. Abel、D. A. Armitage、R. P. Bush

  DOI：10.1039/jr9640005584

  日期：——
• Burilov, A. R.; Barulin, A. A.; Pudovik, M. A., Journal of general chemistry of the USSR, 1989, vol. 59, # 9.2, p. 1905 - 1906
  作者：Burilov, A. R.、Barulin, A. A.、Pudovik, M. A.、Pudovik, A. N.

  DOI：——

  日期：——

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