substituted benzenethiol | 67864-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: substituted benzenethiol
• 英文别名: 4-nitro-benzenesulfenic acid；(4-nitro-phenyl)-sulfanol；4-Nitrobenzolsulfensaeure；4-Nitrobenzene-1-SO-thioperoxol；1-hydroxysulfanyl-4-nitrobenzene
• CAS: 67864-01-1
• 化学式: C₆H₅NO₃S
• 分子量: 171.177
• InChiKey: GVNNJYIYEOXKTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  substituted benzenethiol 以40%的产率得到
  参考文献：
  名称：

  DAVIS F. A.; JENKINS R. H. JR., J. AMER. CHEM. SOC., 1980, 102, NO 27, 7967-7969

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(butylsulfinyl)-4-nitrobenzene 生成 substituted benzenethiol
  参考文献：
  名称：

  DAVIS F. A.; JENKINS R. H. JR., J. AMER. CHEM. SOC., 1980, 102, NO 27, 7967-7969

  摘要：

  DOI：

文献信息

• Novel azo dye compound
  申请人：Kobayashi Katsumi

  公开号：US20060142553A1

  公开（公告）日：2006-06-29

  A compound represented by formula (I): Formula (I) wherein Z 1 and Z 2 each are atoms necessary for forming an aromatic ring; V 1 and V 2 each are a substituent W 1 or W 2 ; when at least one V 1 is W 1 , at least one V 2 is W 2 , or when at least one V 1 is W 2 , at least one V 2 is W 1 ; r is 1 to 4; s is 1 to 4; M 1 is a counter ion; m 1 is the number necessary for neutralizing charge; W 1 is a hydroxyl, primary- or secondary- or tertiary-amino, acylamino, or sulfonamido group; W 2 is a nitro, cyano, alkoxycarbonyl, aryloxycarbonyl, alkyl- or aryl-sulfonyl, carbamoyl, sulfamoyl, alkenyl, alkynyl, aryl, heterocyclic, sulfo, carboxyl, heterocyclic oxy, ammonio, alkyl- or aryl-sulfinyl, alkyl- or aryl-sulfonyl, acyl, or aryl- or heterocyclic-azo group; and the aromatic ring may have a substituent other than V 1 and V 2 .

  化合物的化学式为（I）：化学式（I）其中Z1和Z2各自是形成芳香环所必需的原子；V1和V2各自是取代基W1或W2；当至少一个V1是W1时，至少一个V2是W2，或者当至少一个V1是W2时，至少一个V2是W1；r为1至4；s为1至4；M1是一个计数离子；m1是中和电荷所需的数量；W1是羟基，一级、二级或三级氨基，酰胺基或磺酰胺基；W2是硝基，氰基，烷氧羰基，芳基氧羰基，烷基或芳基磺酰基，氨基甲酰基，磺胺基，烯基，炔基，芳基，杂环，磺基，羧基，杂环氧基，铵基，烷基或芳基亚砜基，烷基或芳基磺酰基，酰基，或芳基或杂环偶氮基；芳香环可能具有除V1和V2之外的取代基。
• Method of Producing Peptide
  申请人：Murao Hiroshi

  公开号：US20090069538A1

  公开（公告）日：2009-03-12

  The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.

  本发明涉及一种肽的制备方法，其特征在于，在缩合反应后将反应混合物与碱接触以水解，同时保持碱性条件，直到酸组分的剩余未反应活性酯的比例在液相肽合成方法中降至1％以下。根据本发明，可以通过连续的液相合成方法简单高效地生产高纯度的目标肽。此外，本发明涉及一种肽的制备方法，其特征在于，在液相肽合成方法中使用与水不相溶的酰胺型溶剂。根据本发明，可以通过液相合成方法生产各种肽，而不受目标肽氨基酸序列的限制。
• METHOD OF PRODUCING PEPTIDE
  申请人：KANEKA CORPORATION

  公开号：US20140288268A1

  公开（公告）日：2014-09-25

  The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.

  本发明涉及一种肽的制备方法，其特征在于在缩合反应后将反应混合物与碱接触以水解，同时维持碱性条件，直到液相肽合成方法中酸组分的剩余未反应活性酯的比例降至1％或更低。根据本发明，可以通过连续的液相合成方法简单高效地生产高纯度的目标肽。此外，本发明涉及一种肽的制备方法，其特征在于在液相肽合成方法中使用与水不相溶的酰胺型溶剂。根据本发明，可以通过液相合成方法生产各种不受目标肽氨基酸序列限制的肽。
• Aromatic sulfenates for type I phototherapy
  申请人：MALLINCKRODT INC.

  公开号：US20030158127A1

  公开（公告）日：2003-08-21

  The present invention discloses novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of free radicals, the reactive intermediate produced upon photofragmentation of the sulfenate moiety, with the tissue of interest.

  本发明公开了用于肿瘤和其他病变光疗的新型亚磺酸盐衍生物及其生物结合剂。本发明的亚硫酸盐可吸收电磁波谱中的低能量紫外线、可见光或近红外（NIR）区域。光疗效果是由自由基（亚磺酸盐分子光碎裂时产生的活性中间体）与相关组织的直接相互作用引起的。
• Happer,D.A.R. et al., Australian Journal of Chemistry, 1973, vol. 26, p. 121 - 134
  作者：Happer,D.A.R. et al.

  DOI：——

  日期：——