2-(4-丁基氨基苯甲酰)氧乙基-二乙基-氯化铵 | 16488-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(4-丁基氨基苯甲酰)氧乙基-二乙基-氯化铵
• 英文名称: p-Butylaminobenzoyldiethylaminoethyl hydrochloride
• 英文别名: 2-(diethylamino)ethyl 4-(butylamino)benzoate;hydrochloride
• CAS: 16488-48-5
• 化学式: C17H29ClN2O2
• 分子量: 328.9
• InChiKey: XTIUAXFQEAMQRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.02
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  42.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2923900090

制备方法与用途

类别：有毒物质

毒性分级：高毒

急性毒性：

• 腹腔注射 - 大鼠 LD50: 27 毫克/公斤
• 口服 - 小鼠 LD50: 156 毫克/公斤

可燃性危险特性：热分解时排出有毒的氮氧化物和氯化氢烟雾

储运特性：

• 库房应通风、低温干燥
• 需与食品原料分开存放

灭火剂：

• 水
• 泡沫
• 二氧化碳
• 干粉

文献信息

• AUTO-MAGNETIC METAL SALEN COMPLEX COMPOUND
  申请人：IHI Corporation

  公开号：EP2682384A1

  公开（公告）日：2014-01-08

  The molecular structures of metal-salen complexes which exerts pharmacological effects are clarified and the metal-salen complexes having such molecular structures and their derivatives are provided. A metal-salen complex compound is characterized in that a metal atom part in each of multiple molecules of the metal-salen complex or its derivative is multimerized via water.

  金属-萨伦络合物的分子结构对产生药理效应进行了澄清，并提供了具有这种分子结构的金属-萨伦络合物及其衍生物。金属-萨伦络合物化合物的特点在于，金属-萨伦络合物或其衍生物的多个分子中的金属原子部分通过水进行多聚化。
• AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND
  申请人：IHI Corporation

  公开号：EP2357166A1

  公开（公告）日：2011-08-17

  The present invention provides a drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to the target diseased site. The drug can be delivered to the diseased site using the magnetic properties of the drug per se without using a carrier made of a magnetic substance as in the conventional methods.

  本发明提供了一种利用由以下通式表示的金属沙仑络合物的磁性的药物，通过将药物与金属沙仑络合物化学结合，使预定药物磁化，从而将药物输送到目标患病部位。利用药物本身的磁性可将药物输送到患病部位，而无需像传统方法那样使用由磁性物质制成的载体。
• Device and method for delivering an oral care agent
  申请人：Ranir/DCP Corporation

  公开号：EP2489329A1

  公开（公告）日：2012-08-22

  An oral care agent delivery device is provided which comprises a permanently deformable backing layer (170), an anchor layer (180) overtop the backing layer, and an oral care layer (190) overtop the anchor layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer (190) comprises at least one oral care agent and at least one hydrophilic polymer. The oral care layer is in contact with the anchor layer and forms an adhesive bond with the anchor layer; however, the oral care layer is minimally invested in the anchoring layer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

  提供了一种口腔护理剂输送装置，它包括一个可永久变形的背衬层（170）、一个覆盖在背衬层上的锚层（180）和一个覆盖在锚层上的口腔护理层（190）。该装置的尺寸适合套在受试者上牙弓或下牙弓的多颗牙齿上。口腔护理层 (190) 包括至少一种口腔护理剂和至少一种亲水性聚合物。口腔护理层与锚定层接触，并与锚定层形成粘合；然而，口腔护理层在锚定层中的投入极少。水合时，口腔护理层相对于使用者牙齿表面的粘附力足以将装置固定在使用者的牙齿上。该装置还可以有一种口腔护理剂，在口腔护理层水合时被激活，或者口腔护理层随着时间的推移释放口腔护理剂。
• DEVICE HAVING ARRAY PROVIDED WITH FINE PROTRUSIONS
  申请人：Hisamitsu Pharmaceutical Co., Inc.

  公开号：EP2578264A1

  公开（公告）日：2013-04-10

  An array 1 provided with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0 < (a/b) ≤ 7.5 holds.

  装有微突起的阵列 1 由基座 2 和锥形微突起 3 组成，每个微突起都位于基座 2 上，并从底部向尖端逐渐变细。将每个微突起 3 的任意一侧从顶端到底部的距离设为 a，并将代表距离 a 的第一条线段投影到基座 2 上的第二条线段的长度设为 b，则 1.0 < (a/b) ≤ 7.5 的关系成立。
• ARRAY WITH FINE PROTRUSIONS
  申请人：Hisamitsu Pharmaceutical Co., Inc.

  公开号：EP2578265A1

  公开（公告）日：2013-04-10

  An array 1 with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0 < (a/b) ≤ 7.5 holds.

  带有微突起的阵列 1 由基座 2 和锥形微突起 3 组成，每个微突起 3 都位于基座 2 上，并从底部向尖端逐渐变细。将每个微突起 3 的任意一侧从尖端到底部的距离设为 a，并将代表距离 a 的第一条线段投影到基座 2 上的第二条线段的长度设为 b，则 1.0 < (a/b) ≤ 7.5 的关系成立。