3-tert-butyl-7,8,12,15,16-pentaoxadispiro[5.2.5.2]hexadecane | 1094165-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 3-tert-butyl-7,8,12,15,16-pentaoxadispiro[5.2.5.2]hexadecane
• 英文别名: 3-Tert-butyl-7,8,12,15,16-pentaoxadispiro[5.2.59.26]hexadecane；3-tert-butyl-7,8,12,15,16-pentaoxadispiro[5.2.59.26]hexadecane
• CAS: 1094165-40-8
• 化学式: C₁₅H₂₆O₅
• 分子量: 286.368
• InChiKey: CXAZFRCTGSVCKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tetrahydro-2H-pyran-4,4-diyl dihydroperoxide 、 4-叔丁基环己酮 在 rhenium(VII) oxide 作用下， 以 2,2,2-三氟乙醇 为溶剂， 反应 0.5h， 以86%的产率得到3-tert-butyl-7,8,12,15,16-pentaoxadispiro[5.2.5.2]hexadecane
  参考文献：
  名称：

  Broadly Applicable Synthesis of 1,2,4,5-Tetraoxanes

  摘要：

  Re(2)O7 is a mild and efficient catalyst for the high-yielding condensation of 1,1-dihydroperoxides with ketones or aldehydes to form 1,2,4,5-tetraoxanes, Including targets not easily prepared via existing methodology. When applied in tandem with a recently reported Re(VII)-catalyzed synthesis of 1,1-dihydroperoxides, the reaction provides a high-yielding one-pot conversion of ketones or aldehydes to tetraoxanes.

  DOI：

  10.1021/ol8023874

文献信息

• Broadly Applicable Synthesis of 1,2,4,5-Tetraoxanes
  作者：Prasanta Ghorai、Patrick H. Dussault

  DOI：10.1021/ol8023874

  日期：2009.1.1

  Re(2)O7 is a mild and efficient catalyst for the high-yielding condensation of 1,1-dihydroperoxides with ketones or aldehydes to form 1,2,4,5-tetraoxanes, Including targets not easily prepared via existing methodology. When applied in tandem with a recently reported Re(VII)-catalyzed synthesis of 1,1-dihydroperoxides, the reaction provides a high-yielding one-pot conversion of ketones or aldehydes to tetraoxanes.