(8-Methyl-2-morpholin-4-yl-4-oxochromen-7-yl) trifluoromethanesulfonate | 130737-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (8-Methyl-2-morpholin-4-yl-4-oxochromen-7-yl) trifluoromethanesulfonate
• CAS: 130737-49-4
• 化学式: C₁₅H₁₄F₃NO₆S
• 分子量: 393.34
• InChiKey: QLWFLZPRRHLEQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  90.5
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (8-Methyl-2-morpholin-4-yl-4-oxochromen-7-yl) trifluoromethanesulfonate 生成 7-hydroxy-8-methyl-2-morpholinyl-4H-1-benzopyran-4-one
  参考文献：
  名称：

  PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues

  摘要：

  Synthetic 2-morpholinochromones, including the known PI3-kinase inhibitor LY294002, have been evaluated in vitro as inhibitors of isolated human platelet phosphodiesterases. Inhibition of the cAMP-phosphodiesterases, PDE2 and PDE3 by LY294002 is reported for the first time. Preliminary screening across a range of 2-morpholinochromones has revealed structural features for optimised PDE2 inhibition. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.043
• 作为产物：
  描述：

  4-乙酰基吗啉 在 三氟甲磺酸酐 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (8-Methyl-2-morpholin-4-yl-4-oxochromen-7-yl) trifluoromethanesulfonate
  参考文献：
  名称：

  PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues

  摘要：

  Synthetic 2-morpholinochromones, including the known PI3-kinase inhibitor LY294002, have been evaluated in vitro as inhibitors of isolated human platelet phosphodiesterases. Inhibition of the cAMP-phosphodiesterases, PDE2 and PDE3 by LY294002 is reported for the first time. Preliminary screening across a range of 2-morpholinochromones has revealed structural features for optimised PDE2 inhibition. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.043

文献信息

• ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES
  申请人：THE UPJOHN COMPANY

  公开号：EP0459983A1

  公开（公告）日：1991-12-11
• US5703075A
  申请人：——

  公开号：US5703075A

  公开（公告）日：1997-12-30
• [EN] ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES
  申请人：THE UPJOHN COMPANY

  公开号：WO1990006921A1

  公开（公告）日：1990-06-28

  (EN) This invention relates to compounds of formula (I) which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of formula (I) are useful inhibitors of cell proliferation.(FR) L'invention concerne des composés de la formule (I), utiles en association avec un support pharmaceutique en tant qu'agents antiathérosclérotiques. De plus, divers composés de la formule (I) sont des inhibiteurs utiles de prolifération de cellules.
• PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues
  作者：Belinda M. Abbott、Philip E. Thompson

  DOI：10.1016/j.bmcl.2004.03.043

  日期：2004.6

  Synthetic 2-morpholinochromones, including the known PI3-kinase inhibitor LY294002, have been evaluated in vitro as inhibitors of isolated human platelet phosphodiesterases. Inhibition of the cAMP-phosphodiesterases, PDE2 and PDE3 by LY294002 is reported for the first time. Preliminary screening across a range of 2-morpholinochromones has revealed structural features for optimised PDE2 inhibition. (C) 2004 Elsevier Ltd. All rights reserved.