溴化铁(III) | 10031-26-2

• 物质功能分类: 无机化工 - 无机盐 - 金属卤化物及卤酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属盐
• 中文名称: 溴化铁(III)
• 中文别名: 溴化铁；三溴高铁；溴化高铁；三溴化铁
• 英文名称: iron (III) bromide
• 英文别名: iron bromide；iron tribromide；Ferric bromide；iron(3+);tribromide
• CAS: 10031-26-2
• 化学式: Br₃Fe
• 分子量: 295.559
• InChiKey: FEONEKOZSGPOFN-UHFFFAOYSA-K

物化性质

• 熔点：
  200 °C
• 密度：
  4.500
• 溶解度：
  溶于乙醇、乙醚
• 暴露限值：
  ACGIH: TWA 1 mg/m3NIOSH: TWA 1 mg/m3
• 稳定性/保质期：
  除可溶于水外，它也溶于乙醇、乙醚等溶剂。受热时会分解为溴化亚铁和溴，在90℃时溴的蒸气压约为8.14×10²帕斯卡，而到了139℃时则增至1.13×10⁵帕斯卡。这种物质对光敏感，微溶于液氨。曝露在空气中或日光下会失去溴。它主要用于医药、化学分析，制备溴盐，并作为有机反应的催化剂。

计算性质

• 辛醇/水分配系数(LogP)：
  2.53
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

溴主要通过吸入进入人体，但也可以通过皮肤接触。溴盐可以摄入。由于溴的活性，它会迅速形成溴化物并可能沉积在组织中，取代其他卤素。

Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

溴是一种强大的氧化剂，能够从粘膜的水分中释放出氧自由基。这些自由基也是有力的氧化剂，能够造成组织损伤。此外，氢溴酸和溴酸的形成将导致二次刺激。溴离子还已知会影响中枢神经系统，导致溴中毒。这被认为是溴离子取代神经递质和传输系统中的氯离子的结果，从而影响许多突触过程。（L626, L627, A543）

Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

溴蒸气会引起刺激和对粘膜的直接损害。元素溴也会烧伤皮肤。溴化物离子是一种中枢神经系统抑制剂，长期暴露会产生神经元效应。这被称为溴中毒，可能导致从中睡意到昏迷、恶病质、昏迷、反射丧失或病理反射、阵挛性癫痫、震颤、共济失调、神经敏感性丧失、瘫痪、眼乳头水肿、言语异常、脑水肿、谵妄、攻击性和精神病的中心反应。

Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L626）；吸入（L626）；皮肤给药（L626）

Oral (L626) ; inhalation (L626) ; dermal (L626)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

溴蒸气会引起刺激和对粘膜的直接损害。症状包括流泪、流鼻涕、眼部刺激伴有来自咽和上呼吸道的粘液分泌、咳嗽、呼吸困难、窒息、喘息、鼻出血和头痛。溴离子是一种中枢神经系统抑制剂，会引起共济失调、言语不清、震颤、恶心、呕吐、乏力、眩晕、视觉障碍、不稳、头痛、记忆和注意力受损、定向障碍和幻觉。这被称为溴中毒。

Bromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. This is called bromism. (L626, L627)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• TSCA：
  Yes
• 危险等级：
  8
• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  28275900
• 危险品运输编号：
  UN3260
• 危险类别：
  8
• 包装等级：
  III
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  | 室温 |

SDS

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Section 1: Product Identification
Chemical Name: Iron (III) bromide, anhydrous,99%
CAS Registry Number: 10031-26-2
Formula: FeBr3
EINECS Number: 233-089-1
Chemical Family: metal halide
Synonym: Ferric bromide

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 10031-26-2 100% 1mg/m3 (as Fe no data

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Section 3: Hazards Identification
Emergency Overview: Irritating to skin, eyes and respiratory tract.
Primary Routes of Exposure: Ingestion, inhalation, skin, eyes
Eye Contact: Causes moderate to severe irritation of the eyes.
Skin Contact: Causes irritation, redness, and pain to skin.
Inhalation: Dust causes coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting.
Ingestion: Soluble iron salts may cause poisoning.
Acute Health Affects: Irritating to skin, eyes and respiratory tract.
Prolonged ingestion may lead to damage to the liver and pancreas. Prolonged inhalation of dusts may cause
Chronic Health Affects:
pulmonary fibrosis.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

---

SECTION 5: Fire Fighting Measures
Flash Point: not applicable
Autoignition Temperature: none
Explosion Limits: none
Extinguishing Medium: none required
If involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure self-contained
Special Fire Fighting Procedures:
breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit corrosive hydrogen bromide fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
To avoid raising dust, small spills can be mixed with powdered sodium bicarbonate, lime, or calcium carbonate
Spill and Leak Procedures:
and swept up.

---

SECTION 7: Handling and Storage
Store material in a tightly sealed bottle away from moisture. If possible, handle material in an efficient fume
Handling and Storage:
hood. Prolonged exposure to the atmosphere may lead to degradation of the product.

---

SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear appropriate chemical resistant gloves and protective clothing.
Ventilation: If possible, handle the material in an efficient fume hood.
If in form of fine dust and ventilation is not available a respirator should be worn. The use of respirators
Respirator:
requires a Respirator Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: If possible, handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

---

SECTION 9: Physical and Chemical Properties
Color and Form: reddish-black xtl.
Molecular Weight: 295.57
Melting Point: subl. dec.
Boiling Point: no data
Vapor Pressure: no data
Specific Gravity: no data
Odor: none
Solubility in Water: soluble

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SECTION 10: Stability and Reactivity
Stability: hygroscopic
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: contact with moisture
Incompatibility: Oxidizing agents, water, alcohols, active metals and halogens
Decomposition Products: with moisture: hydrobromic acid and metal oxides.

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SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files.
Carcinogenic Effects: no data
Mutagenic Effects: no data
Tetratogenic Effects: no data

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SECTION 12: Ecological Information
Ecological Information: No information available

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

---

SECTION 14: Transportation
Shipping Name (CFR): Non-hazardous
Hazard Class (CFR): NA
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): NA
Shipping Name (IATA): Non-hazardous
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): NA

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SECTION 15: Regulatory Information
TSCA: Listed in the TSCA inventory.
SARA (Title 313): Title compound not listed.
Second Ingredient: none

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

理化性质

溴化铁是一种棕黄色或深红棕色的固体。它易溶于水，其水溶液略显酸性，并可以结晶出暗绿色的FeBr₃·6H₂O。此外，固体溴化铁也可溶解在给电子溶剂（如乙醚、乙醇）中。固体溴化铁具有与氯化铁相似的聚合物结构，每个铁原子为六配位，八面体型结构，连接着六个溴原子。

制备

溴化铁可以通过铁与溴反应制备：

[ 2Fe + 3Br_2 \rightarrow 2FeBr_3 ]

另一种方法是将溴化亚铁与溴在170-200°C时进行反应，也可以得到溴化铁：

[ 2FeBr_2 + Br_2 \rightarrow 2FeBr_3 ]

催化反应

溴化铁可以催化苯与液溴生成溴苯的反应。

此外，溴化铁样品难以制纯，原因是它不稳定。在高温（200°C以上）或煮沸其水溶液时，溴化铁容易分解为溴化亚铁和溴：

[ 2FeBr_3 \rightarrow 2FeBr_2 + Br_2 ]

用途

溴化铁用作有机合成催化剂。

反应信息

• 作为反应物：
  描述：

  溴化铁(III) 以 水 为溶剂， 生成 氢溴酸
  参考文献：
  名称：

  Loewig, C., Das Brom, Heidelberg 1829, S. 133

  摘要：

  DOI：
• 作为产物：
  描述：

  tetrabromoferrate 生成 溴化铁(III)
  参考文献：
  名称：

  NANDZE, MITIO;NISIMURA, YAMAXARU;VATANABEH, CACAO

  摘要：

  DOI：
• 作为试剂：
  描述：

  苯乙烯 、 二苯基二硒醚 、 N-甲基苯胺 在 溴化铁(III) 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以70%的产率得到N-methyl-N-(1-phenyl-2-(phenylselanyl)ethyl)aniline
  参考文献：
  名称：

  一种双取代苯乙烯类衍生物的制备方法

  摘要：

  一种双取代苯乙烯类衍生物的制备方法，本发明涉及一种双取代苯乙烯类衍生物的制备方法。本发明的目的是为了解决现有方法合成双取代苯乙烯类衍生物步骤繁琐、产率低且污染环境的问题，本发明在室温下，在氮气或者氧气气氛下，将苯乙烯衍生物，苯胺类化合物，二苯基二硒醚类化合物和光催化剂溶解在有机溶剂中，混合均匀，置于蓝色LEDs灯下进行反应，反应结束后，旋蒸溶剂，再分离纯化，即可得到双取代苯乙烯类衍生物；本发明提供了一种简洁的一步法合成方法，该方法解决了现有合成需要加热和过渡金属催化体系导致的产率低、方法环保性差的问题，寻求到一条绿色高效、条件温和、方法简单且操作方便的合成路线。本发明应用于有机合成领域。

  公开号：

  CN110305054B

文献信息

• Catalytic alkylation of arylGrignard reagents by iron(<scp>iii</scp>) amine-bis(phenolate) complexes
  作者：Xin Qian、Louise N. Dawe、Christopher M. Kozak

  DOI：10.1039/c0dt01239d

  日期：——

  [FeL2(μ-Cl)]2 (2) and [FeL3(μ-Cl)]2 (3). In the solid state, these complexes exist as chloride-bridged dimers giving distorted trigonal bipyramidal iron(III) ions. Reaction of H2L1 with FeBr3, however, results in the formation of a tetrahedral iron(III) complex possessing two bromide ligands. The amine-bis(phenolate) ligand is bidentate in this complex and bonds to the iron(III) ion via the phenolate O-donors

  正丙基氨基-N，N-双（2-亚甲基-4-叔丁基-6-甲基苯酚），H 2 L1，正丙基氨基-N，N-双（2-亚甲基-4,6-di）的反应-叔丁基苯酚），H 2 L2和苄氨基-N，N-双（2-亚甲基-4-叔丁基-6-甲基苯酚），H 2 L3（无水）氯化铁在碱的存在下产生产物[Fe L1（μ-Cl）] 2（1），[Fe L2（μ-Cl）] 2（2）和[Fe L3（μ-Cl）] 2（3） 。在固态下，这些络合物以氯桥联的二聚体形式存在，产生扭曲的三角双锥体铁（III）离子。然而，H 2 L1与FeBr 3的反应导致形成具有两个溴化物配体的四面体铁（III）配合物。胺-二（酚盐）配位体是在这种复杂的二齿并粘合到铁（III）离子通过酚盐O供体 中心胺供体被质子化，产生季铵化的铵碎片，并且铁（III）中心具有负的形式电荷。结果，该络合物是两性离子的，并配制成FeBr 2 L1H（4）。配合物1是一种空气
• Transition metal complexes of vitamins B6-related compounds. 2. Synthesis and properties of several iron(III) complexes of pyridoxylideneglycine and 5′-phosphopyridoxylideneglycine
  作者：James T. Wrobleski、Gary J. Long

  DOI：10.1016/s0020-1693(00)89386-x

  日期：1979.1

  that PLgly and PLPgly are coordinated to iron(III) through their azomethine nitrogen, phenolic oxygen, and carbpxylic oxygen donor atoms. These spectra also indicate the presence of coordinated water. The complexes are predominantly high-spin with magnetic moments which decrease from ca. 5.8 μB at room temperature to ca. 5.40 μB at 120 K. This behavior is explained in terms of weak intermolecular anti-ferromagnetic

  摘要制备了吡啶氧亚苄基甘氨酸和5'-磷酸氧亚苄基甘氨酸的铁（III）配合物，并研究了它们的电子和结构性质。这些化合物是基本的单体五配位络合物Fe（PLgly）（H2O）X，其中PLgly是吡啶氧亚二甘氨酸席夫碱二价阴离子，X是Cl，Br或OAc和Fe（PlPgly）（H2O）（OAc），其中PLPgly是5'-磷酰氧基亚苄基甘氨酸。红外光谱表明PLgly和PLPgly通过其偶氮甲基氮，酚氧和羰基氧供体原子与铁（III）配位。这些光谱还表明存在配位水。配合物主要是高自旋的，其磁矩从ca减小。室温下约5.8μB 120 K时为5.40μB。用弱分子间反铁磁耦合来解释这种行为。这些化合物的Mossbauer效应光谱参数与五配位铁（III）一致，但不能消除在第六配位位点弱结合的可能性。化学异构体的位移范围为0.40-0.50 mm / s（相对于天然α铁箔），四极相互作用为ca。0.70毫米/秒 在6特斯拉和4
• Characterization of some high-spin iron(III) complexes with urea derivaties. Crystal structure of diaquatetrakis(perhydropyrimidin-2-one)iron trichloride dihydrate and of perhydrophyrimidin-2-one
  作者：Sandro Calogero、Umberto Russo、Antonio Del Pra'

  DOI：10.1039/dt9800000646

  日期：——

  High-spin complexes of the type [FeL6]X3, where L = urea, 1,3-dimethylurea (dmu), 1,3-diethylurea (deu), perhydropyrimidin-2-one (1,3-trimethyleneurea, tu), imidazolidin-2-one (1,3-ethyleneurea, eu), and X = ClO4 or Br, and [Fe(tu)4(OH2)2]Cl3·2H2O have been prepared. A discrete octahedral geometry for all these complexes has been inferred from i.r., magnetic susceptibility, and Mössbauer measurements

  [FeL 6 ] X 3类型的高纺复合物，其中L =尿素，1,3-二甲基脲（dmu），1,3-二乙基脲（deu），全氢嘧啶-2-酮（1,3-三亚甲基脲，tu ），咪唑烷-2-酮（1,3-亚乙基，EU），和X = CLO 4或Br，和的[Fe（TU）4（OH 2）2 ]氯3 ·2H 2 ö已经制备。从红外，磁化率和Mössbauer测量可以推断出所有这些配合物的离散八面体几何形状。[Fe（tu）4（OH 2）2 ] Cl 3 ·2H 2的晶体结构O已通过三维Patterson合成进行了求解：晶体为正交晶体，空间群P 2 1 2 1 2 1 1，其中a = 18.627（9），b = 15.555（7），c = 9.876（5）Å，Z = 4，对于2567个可观察到的反射，精炼为R 0.056。铁原子与两个顺式配位-水分子中的两个氧原子[分别为Fe-O 2.028（5）和2.036（5）Å]和tu配体的四个氧原子[Fe-O
• Synthesis, Characterization, Thermal Decomposition and Antifungal Studies of Cr(III), Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) Complexes of N,N′-bis[1,3-benzodioxol-5ylmethylene]ethane-1, 2-diamine
  作者：Prasad M. Alex、K. K. Aravindakshan

  DOI：10.1080/15533170903433295

  日期：2009.11.30

  Schiff base namely, N,N′-bis[1,3benzodioxol-5-ylmethylene] ethane-1,2-diamine was synthesized by condensing piperonaldehyde (3,4-dioxymethylenebenzaldehyde) with ethylenediamine. Cr(III), Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) complexes of this chelating/bridging ligand were synthesized using acetates, chlorides, bromides, nitrates and perchlorates of these metals. The ligand and the complexes were characterized

  通过将戊醛（3,4-二甲醛）与乙二胺缩合来合成二齿/四齿席夫碱，即N，N'-双[1,3苯并二恶唑-5-基亚甲基]乙烷-1,2-二胺。该螯合/桥联配体的Cr（III），Mn（II），Fe（III），Co（II），Ni（II）和Cu（II）络合物是使用这些化合物的乙酸盐，氯化物，溴化物，硝酸盐和高氯酸盐合成的金属。配体和配合物通过元素分析表征11 H NMR，UV-vis和IR光谱，电导率和磁化率测量以及热重分析。配体在其某些配合物中显示出桥联性质，如磁性和微观分析数据所证明。分析了三种配合物的热谱图，并确定了不同分解阶段的动力学参数。在胡萝卜琼脂培养基中测试了配体及其某些复合物对辣椒疫霉菌的抗真菌活性。
• Iron Phosphinimide and Phosphinimine Complexes:  Catalyst Precursors for Ethylene Polymerization
  作者：Luc LePichon、Douglas W. Stephan、Xiaoliang Gao、Qinyan Wang

  DOI：10.1021/om011041m

  日期：2002.4.1

  -O) 5. These species have also been evaluated as catalysts for the polymerization of ethylene and copolymerization of ethylene/octene. These species were found to be single-site catalysts even under rather demanding conditions (50−160 °C, 100−300 psig ethylene), although the activities are generally low. Compound 5 affords polymer similar to that produced by 3, suggesting that MAO dehydrates 5 generating

  的Li [NP的反应吨-Bu 3与的FeCl] 2得到[氯3的Fe 2（μ-NP吨-Bu 3）2 ] 1以71％的产率。这种混合价的Fe（III）-Fe（II）经受可逆单电子氧化以生成[氯3的Fe 2（μ-NP吨-Bu 3）2 ] +。化学氧化用的[Cp 2的Fe] PF 6的产率[氯2的Fe（μ-NP吨-Bu 3）] 2 2。Li [NP的反应吨-Bu 3 ]与FeBr 3次，得到[BR 4的Fe 2（μ-NP吨-Bu 3）2 ] 3，而的FeCl的反应3与我3 SiNPCy 3给出[氯2的Fe（μ-NPCY 3）] 2 4。3的水解产生了[[ t- Bu 3 PNH）Br 2 Fe] 2（μ-O）5物质。还已经评估了这些物质作为乙烯聚合和乙烯/辛烯共聚的催化剂。尽管活性通常较低，但即使在相当苛刻的条件下（50-160°C，100-300 psig乙烯），也发现这些物种是单中心催化剂。化

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