2-(2-methoxy-4-nitro-1H-imidazol-1-yl)-1-(4-nitrophenyl)ethanol | 1283135-50-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-methoxy-4-nitro-1H-imidazol-1-yl)-1-(4-nitrophenyl)ethanol
• 英文别名: 2-(2-Methoxy-4-nitro-imidazol-1-yl)-1-(4-nitrophenyl)ethanol；2-(2-methoxy-4-nitroimidazol-1-yl)-1-(4-nitrophenyl)ethanol
• CAS: 1283135-50-1
• 化学式: C₁₂H₁₂N₄O₆
• 分子量: 308.25
• InChiKey: NSNGSDYVGWOUJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-氯-1-(4-硝基苯基)乙醇 在 四丁基碘化铵 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 2-(2-methoxy-4-nitro-1H-imidazol-1-yl)-1-(4-nitrophenyl)ethanol
  参考文献：
  名称：

  Synthesis and antitubercular activity of monocyclic nitroimidazoles: Insights from econazole

  摘要：

  We have designed and synthesized econazole-derived nitroimidazoles to investigate the antitubercular activity of the nitroimidazole compounds. The introduction of a nitro group at the 4-position of the imidazole on econazole abolished the antitubercular activity. However, alcoholic nitroimidazoles 4 and 6 compounds were active against Mycobacterium tuberculosis (Mtb). While the MIC value of econazole was 16 mu g/mL, the MIC of 6a and 6f turned out to be 0.5 mu g/mL. In particular, the activity of 6f against non-replicating Mtb was as good as PA-824, which is currently in clinical phase II studies as an antitubercular agent. Overall, alcohol compounds 4 and 6 tend to be more active than ether compounds 5 and 7. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.128

文献信息

• Synthesis and antitubercular activity of monocyclic nitroimidazoles: Insights from econazole
  作者：Sang-Ho Lee、Suhyun Kim、Min-Han Yun、Yong Sup Lee、Sang-Nae Cho、Taegwon Oh、Pilho Kim

  DOI：10.1016/j.bmcl.2010.12.128

  日期：2011.3

  We have designed and synthesized econazole-derived nitroimidazoles to investigate the antitubercular activity of the nitroimidazole compounds. The introduction of a nitro group at the 4-position of the imidazole on econazole abolished the antitubercular activity. However, alcoholic nitroimidazoles 4 and 6 compounds were active against Mycobacterium tuberculosis (Mtb). While the MIC value of econazole was 16 mu g/mL, the MIC of 6a and 6f turned out to be 0.5 mu g/mL. In particular, the activity of 6f against non-replicating Mtb was as good as PA-824, which is currently in clinical phase II studies as an antitubercular agent. Overall, alcohol compounds 4 and 6 tend to be more active than ether compounds 5 and 7. (C) 2010 Elsevier Ltd. All rights reserved.