3,4-dimethyl-N-4-methylphenylbenzamide | 314046-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dimethyl-N-4-methylphenylbenzamide
• 英文别名: 3,4-dimethyl-N-p-tolylbenzamide；3,4-dimethyl-N-(4-methylphenyl)benzamide
• CAS: 314046-47-4
• 化学式: C₁₆H₁₇NO
• mdl: MFCD01215995
• 分子量: 239.317
• InChiKey: UTMHMVRIQVFQML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-4'-methylphenyl-Z-3-chloro-2-(benzylsulfinyl)propenamide 、 2,3-二甲基-1,3-丁二烯 反应 0.5h， 以95%的产率得到3,4-dimethyl-N-4-methylphenylbenzamide
  参考文献：
  名称：

  The influence of reaction conditions on the Diels–Alder cycloadditions of 2-thio-3-chloroacrylamides; investigation of thermal, catalytic and microwave conditions

  摘要：

  介绍了在热、催化和微波条件下，环戊二烯和 2,3-二甲基-1,3-丁二烯与一系列 2-硫代-3-氯丙烯酰胺的 DielsâAlder 环加成反应。讨论了反应条件对环化反应结果的影响，特别是立体选择性和反应效率。虽然环化反应是在硫化物、亚砜和砜的氧化水平上进行的，但使用亚砜衍生物显然有利于立体选择性地构建 DielsâAlder 环加成物。

  DOI：

  10.1039/c0ob00368a

文献信息

• KINASE INHIBITORS
  申请人：Allergan, Inc.

  公开号：US20160096832A1

  公开（公告）日：2016-04-07

  The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调节、调控和/或抑制异常细胞增殖。
• Direct amide synthesis <i>via</i> Ni-mediated aminocarbonylation of arylboronic acids with CO and nitroarenes
  作者：Ni Shen、Chi Wai Cheung、Jun-An Ma

  DOI：10.1039/c9cc06638a

  日期：——

  Herein we describe an alternative and unconventional approach of an aminocarbonylation reaction to access aryl amides from readily available and low-cost arylboronic acids and nitroarenes. Nickel metal can serve as both reductant and catalyst in this direct aminocarbonylation. This protocol exhibits a good functional group compatibility and allows a variety of aryl amides to be synthesized, including

  本文中，我们描述了一种氨基羰基化反应的替代性和非常规方法，可从容易获得的低成本芳基硼酸和硝基芳烃中获得芳基酰胺。在这种直接的氨基羰基化反应中，镍金属既可以充当还原剂，又可以充当催化剂。该方案显示出良好的官能团相容性，并允许合成多种芳基酰胺，包括几种药物样分子。
• HOLLOW FIBER, DOPE COMPOSITION FOR FORMING HOLLOW FIBER, AND METHOD OF PREPARING HOLLOW FIBER USING THE SAME
  申请人：JUNG Chul-Ho

  公开号：US20090282982A1

  公开（公告）日：2009-11-19

  Disclosed is a hollow fiber that includes a hollow positioned at the center of the hollow fiber, macropores positioned at adjacent to the hollow, and mesopores and picopores positioned at adjacent to macropores, and the picopores are three dimensionally connected to each other to form a three dimensional network structure. The hollow fiber includes a polymer derived from polyamic acid, and the polyamic acid includes a repeating unit obtained from aromatic diamine including at least one ortho-positioned functional group with respect to an amine group and dianhydride.
• POLYIMIDE-CO-POLYBENZOXAZOLE COPOLYMER, PREPARATION METHOD THEREOF, AND GAS SEPARATION MEMBRANE COMPRISING THE SAME
  申请人：Lee Young Moo

  公开号：US20110065823A1

  公开（公告）日：2011-03-17

  Disclosed herein are a polyimide-polybenzoxazole copolymer, a method for preparing thereof and a gas separation membrane comprising the same. More specifically, provided are a polyimide-polybenzoxazole copolymer simply prepared through thermal-rearrangement performed by thermally treating a polyimide-poly (hydroxyimide) copolymer as a precursor, a method for preparing the same, and a gas separation membrane comprising the same. The copolymer shows superior gas permeability and gas selectivity, thus being suitable for use in gas separation membranes in various forms such as films, fibers or hollow fibers. The gas separation membrane thus prepared can advantageously endure even harsh conditions such as long operation time acidic conditions and high humidity due to the rigid polymer backbone present in the copolymer.
• METHOD FOR THE SYNTHESIS OF A TWO-DIMENSIONAL OR QUASI-TWO-DIMENSIONAL POLYMER FILM, THE TWO-DIMENSIONAL OR QUASI-TWO-DIMENSIONAL POLYMER FILM AND THE USE
  申请人：TECHNISCHE UNIVERSITÄT DRESDEN

  公开号：US20220325053A1

  公开（公告）日：2022-10-13

  The present invention relates to a method for the synthesis of a two-dimensional or quasi-two-dimensional polymer comprising a surfactant, the two-dimensional or quasi-two-dimensional polymer film and the use for the production of membranes, electronic devices or catalysts.