N-(3-phenylcyclohex-2-enyl)benzamide | 1311150-24-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-phenylcyclohex-2-enyl)benzamide
• 英文别名: N-(3-phenylcyclohex-2-en-1-yl)benzamide
• CAS: 1311150-24-9
• 化学式: C₁₉H₁₉NO
• 分子量: 277.366
• InChiKey: BLVUZLAFIKBGMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-Azido-1-phenyl-1-cyclohexene 以 neat (no solvent) 为溶剂， 反应 25.0h， 生成 N-(3-phenylcyclohex-2-enyl)benzamide
  参考文献：
  名称：

  Chemoselectivity in Coupling of Azides with Thioacids in Solution-Phase and Solvent-Free Conditions

  摘要：

  Solvent-free rapid coupling of monothiocarboxylic acid with azide affords carboxamide chemoselectively. Triphenyl phosphine included as an additive influences the chemoselectivity, yielding carboxamide and thioamide. Similar variation in the chemoselectivity is observed in the absence and presence of triphenyl phosphine in solution-phase methodology. Rapidity and ecofriendliness of the solvent-free approach to yield the products in just 15 min is noteworthy compared to the solution-phase protocol, which has a long reaction time (1-3 days).

  DOI：

  10.1080/00397911.2011.606043

文献信息

• 一种sp³-碳氢键伯胺化反应的催化剂及制备伯胺化合物的方法
  申请人：四川大学华西第二医院

  公开号：CN118084926A

  公开（公告）日：2024-05-28

  本发明提供了一种sp3‑碳氢键伯胺化反应的催化剂及制备伯胺化合物的方法，属于化学合成技术领域。该催化剂的结构如式I所示。本发明利用该催化剂制备伯胺化合物的方法普适性高、反应的底物适用性宽广，环境友好且反应条件温和不苛刻，反应操作简便，具有潜在的工业应用前景。#imgabs0#
• Murugan, Sathish Kumar; Sangaraiah, Nagarajan; Velan, Poovan Shanmuga, Journal of the Brazilian Chemical Society, 2011, vol. 22, # 11, p. 2065 - 2069
  作者：Murugan, Sathish Kumar、Sangaraiah, Nagarajan、Velan, Poovan Shanmuga、Murugan, Dinesh、Ponnuswamy, Alagusundaram

  DOI：——

  日期：——
• Solvent-free protocol for amide bond formation via trapping of nascent phosphazenes with carboxylic acids
  作者：Murugan Sathishkumar、Poovan Shanmugavelan、Sangaraiah Nagarajan、Murugesan Maheswari、Murugan Dinesh、Alagusundaram Ponnuswamy

  DOI：10.1016/j.tetlet.2011.03.069

  日期：2011.6

  A solvent-free synthesis of amides via the coupling of phosphazenes with carboxylic acids is reported. Increasing the rate of heating either by microwave irradiation or conventional heating results in multifold increase in the rate of amide bond formation. Synthesis of a library of amides including a potent antitumour candidate has been accomplished. (C) 2011 Elsevier Ltd. All rights reserved.