2-(4-piperazinyl)-4H-1-benzopyran-4-one | 173209-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-piperazinyl)-4H-1-benzopyran-4-one
• 英文别名: 2-Piperazin-1-ylchromen-4-one
• CAS: 173209-96-6
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: JVUCCCHUNXOKDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  对甲苯磺酸乙酯 、 2-(4-piperazinyl)-4H-1-benzopyran-4-one 在 sodium carbonate 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以55%的产率得到2-(4-Ethyl-piperazin-1-yl)-chromen-4-one
  参考文献：
  名称：

  Di Braccio; Roma; Leoncini, Il Farmaco, 1995, vol. 50, # 10, p. 703 - 711

  摘要：

  DOI：
• 作为产物：
  描述：

  4-hydroxy-2-deoxy-2-thiocoumarin 在 potassium carbonate 作用下， 以 乙二醇 、 丙酮 为溶剂， 反应 2.5h， 生成 2-(4-piperazinyl)-4H-1-benzopyran-4-one
  参考文献：
  名称：

  Di Braccio; Roma; Leoncini, Il Farmaco, 1995, vol. 50, # 10, p. 703 - 711

  摘要：

  DOI：

文献信息

• Compositions and coatings for implantable medical devices
  申请人：Sahajanand Medical Technologies PVT. ltd

  公开号：EP1832289A2

  公开（公告）日：2007-09-12

  A composition comprising at least one polymer, heparin, and at least one pharmaceutically active agent selected from Formula A, Formula B, LY294002, and LY303511 having the formulae

  一种组合物，包含至少一种聚合物、肝素和至少一种选自式 A、式 B、LY294002 和 LY303511 的药物活性剂，其式为
• Methods for suppressing an immune response or treating a proliferative disorder
  申请人：Moss Joel

  公开号：US20070173514A1

  公开（公告）日：2007-07-26

  Disclosed herein are methods for suppressing an immune response in a subject, treating a neoplasm in a subject, or treating a fibroproliferative vascular disease in a subject, that includes administering to the subject a therapeutically effective amount of a 2-(4-piperazinyl)-substituted 4H-1-benzopyran-4-one compound, or a pharmaceutically acceptable salt thereof, having the structure of wherein the presence of each of R 1 and R 2 is optional and R 1 and R 2 are each independently selected from alkyl, substituted alkyl, heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, halogen, hydroxy, or amino.
• COMPOSITIONS COMPRISING POROUS ARTICLES AND USES IN IMPLANTABLE MEDICAL DEVICES
  申请人：Patravale Vandana B.

  公开号：US20070212388A1

  公开（公告）日：2007-09-13

  A composition comprising a first polymer having pores, nanoparticles dispersed within the pores of the first polymer, the nanoparticles comprising a second polymer and at least one pharmaceutically active agent dispersed in the second polymer, and heparin covalently bonded to at least one of the first and second polymer.
• COMPOSITIONS AND COATINGS FOR IMPLANTABLE MEDICAL DEVICES
  申请人：Patravale Vandana B.

  公开号：US20070212393A1

  公开（公告）日：2007-09-13

  An implantable medical device, comprising a polymer coated on at least a portion of the medical device, and a pharmaceutically active agent covalently bonded to the polymer.
• METHODS FOR SUPPRESSING AN IMMUNE RESPONSE OR TREATING A PROLIFERATIVE DISORDER
  申请人：Moss Joel

  公开号：US20120039903A1

  公开（公告）日：2012-02-16

  Disclosed herein are methods for suppressing an immune response in a subject, treating a neoplasm in a subject, or treating a fibroproliferative vascular disease in a subject, that includes administering to the subject a therapeutically effective amount of a 2-(4-piperazinyl)-substituted 4H-1-benzopyran-4-one compound, or a pharmaceutically acceptable salt thereof, having the structure of wherein the presence of each of R 1 and R 2 is optional and R 1 and R 2 are each independently selected from alkyl, substituted alkyl, heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, halogen, hydroxy, or amino.