3,5-bis(2-iodophenyl)-1,2,4-thiadiazole | 1334212-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-bis(2-iodophenyl)-1,2,4-thiadiazole
• CAS: 1334212-40-6
• 化学式: C₁₄H₈I₂N₂S
• 分子量: 490.106
• InChiKey: BAXVQHNHXLETGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(1-萘基)-2,4-二氧杂螺[5.5]十一烷 、 2-iodobenzothioamide 以 甲醇 为溶剂， 以100%的产率得到3,5-bis(2-iodophenyl)-1,2,4-thiadiazole
  参考文献：
  名称：

  An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate

  摘要：

  Aryl thioamides undergo very rapid condensation in the presence of methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles with an easy work-up and a high degree of product purity. The method can be scaled up with no loss in efficiency. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.068

文献信息

• An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate
  作者：Abdelrahman S. Mayhoub、Evgeny Kiselev、Mark Cushman

  DOI：10.1016/j.tetlet.2011.07.068

  日期：2011.9

  Aryl thioamides undergo very rapid condensation in the presence of methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles with an easy work-up and a high degree of product purity. The method can be scaled up with no loss in efficiency. (C) 2011 Elsevier Ltd. All rights reserved.