3-methylbutyl(cyclohexyl)amine hydrochloride | 477588-44-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-methylbutyl(cyclohexyl)amine hydrochloride
• 英文别名: cyclohexyl-isopentyl-amine; hydrochloride；Cyclohexyl-isopentyl-amin; Hydrochlorid；N-(3-Methylbutyl)cyclohexanamine--hydrogen chloride (1/1)；N-(3-methylbutyl)cyclohexanamine;hydrochloride
• CAS: 477588-44-6
• 化学式: C₁₁H₂₃N*ClH
• 分子量: 205.771
• InChiKey: YIRVMSUVBMTFMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.38
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异戊胺 、 环己酮 在 palladium on activated charcoal ammonium formate 作用下， 以 甲醇 、 水 为溶剂， 以70%的产率得到3-methylbutyl(cyclohexyl)amine hydrochloride
  参考文献：
  名称：

  A modified palladium catalysed reductive amination procedure

  摘要：

  New, extended applications of a modified palladium catalysed reductive amination procedure are described; a mechanistic hypothesis alternative to the common imine pathway is proposed. This versatile method advances the usual reductive amination processes in terms of yield and shows high stereoselectivity whether applied to constrained carbonyl compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00530-6

文献信息

• A modified palladium catalysed reductive amination procedure
  作者：Valerio Berdini、Maria C Cesta、Roberto Curti、Gaetano D'Anniballe、Nicoletta Di Bello、Giuseppe Nano、Luca Nicolini、Alessandra Topai、Marcello Allegretti

  DOI：10.1016/s0040-4020(02)00530-6

  日期：2002.7

  New, extended applications of a modified palladium catalysed reductive amination procedure are described; a mechanistic hypothesis alternative to the common imine pathway is proposed. This versatile method advances the usual reductive amination processes in terms of yield and shows high stereoselectivity whether applied to constrained carbonyl compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.