(12-bromododecyloxy)(tert-butyl)dimethylsilane | 134413-60-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (12-bromododecyloxy)(tert-butyl)dimethylsilane
• 英文别名: 12-bromo-1-tert-butyldimethylsilyloxydodecane；(12-Bromo-dodecyloxy)-tert-butyl-dimethyl-silane；12-bromododecoxy-tert-butyl-dimethylsilane
• CAS: 134413-60-8
• 化学式: C₁₈H₃₉BrOSi
• 分子量: 379.497
• InChiKey: NFUQZVUAJDEGGF-UHFFFAOYSA-N

物化性质

• 沸点：
  374.5±15.0 °C(Predicted)
• 密度：
  0.996±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (12-bromododecyloxy)(tert-butyl)dimethylsilane 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以75%的产率得到12-(tert-butyldimethylsilyloxy)dodec-1-ene
  参考文献：
  名称：

  An organocatalytic enantioselective synthesis of (+)-duryne

  摘要：

  An efficient enantioselective synthesis of the potent anticancer agent (+)-duryne was achieved by the use of a one-pot organocatalyzed hydroxylation/Ohira-Bestmann and Grubbs cross-metathesis/selective cis-Wittig reaction. This new approach is envisioned to facilitate the synthesis of every representative member of the family. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.04.004
• 作为产物：
  描述：

  12-((tert-butyldimethylsilyl)oxy)dodecan-1-ol 在 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 (12-bromododecyloxy)(tert-butyl)dimethylsilane
  参考文献：
  名称：

  Synthesis of galactosyl compounds for targeted gene delivery

  摘要：

  Cell-specific DNA delivery offers a great potential for targeted gene therapy. Toward this end, we have synthesized a series of compounds carrying galactose residues as a targeting ligand for asialoglycoprotein receptors of hepatocytes and primary amine groups as a functional domain for DNA binding. Biological activity of these galactosyl compounds in DNA delivery was evaluated in HepG2 and BL-6 cells and compared with respect to the number of galactose residues as well as primary amine groups in each molecule. Transfection. experiments using a firefly luciferase gene as a reporter revealed that compounds with multivalent binding properties were more active in DNA delivery. An optimal transfection activity in HepG2 cells requires seven primary amine groups and a minimum of two galactose residues in each molecule. The transfection activity of compounds carrying multi-galactose residues can be inhibited by asialofetuin, a natural substrate for asialoglycoprotein receptors of hepatocytes, suggesting that gene transfer by these galactosyl compounds is asialoglycoprotein receptor-mediated. These results provide direct evidence in support of our new strategy for the use of small and synthetic compounds for cell specific and targeted gene delivery. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00203-6

文献信息

• The Properties and Role of <i>O</i>-Acyl-ω-hydroxy Fatty Acids and Type I-St and Type II Diesters in the Tear Film Lipid Layer Revealed by a Combined Chemistry and Biophysics Approach
  作者：Tuomo Viitaja、Jan-Erik Raitanen、Jukka Moilanen、Riku O. Paananen、Filip S. Ekholm

  DOI：10.1021/acs.joc.0c02882

  日期：2021.4.2

  isolation from tear samples in sufficient quantities is a tedious task. To provide access to these species in their pure form, and to shed light on their properties, we here report a general strategy for the synthesis and structural characterization of these lipid classes. In addition, we study the organization and behavior of the lipids at the air–tear interface. Through these studies, new insights

  覆盖眼表的泪膜脂质层 (TFLL) 包含几种独特的脂质类别，包括O-酰基-ω-羟基脂肪酸、I-St型二酯和II型二酯。虽然 TFLL 代表了一种独特的生物屏障，在稳定整个泪膜方面起着核心作用，但对单个脂质种类的特性和作用知之甚少。这是因为将它们从足够数量的泪液样本中分离出来是一项繁琐的任务。为了以纯形式获得这些物种，并阐明它们的特性，我们在此报告了这些脂质类别的合成和结构表征的一般策略。此外，我们研究了空气-撕裂界面处脂质的组织和行为。通过这些研究，对结构特征（如双键数量和链长）与薄膜特性（如延展性和抗蒸发性）之间关系的新见解，
• Synthesis of Macrocyclic Lactones<i>via</i>Ring Transformation of 4-(<i>ω</i>-Hydroxyalkyl)-1,3-oxazol-5(4<i>H</i>)-ones
  作者：Stephan P. Fritschi、Anthony Linden、Heinz Heimgartner

  DOI：10.1002/hlca.201600023

  日期：2016.7

  α‐benzamido‐α‐benzyl lactones 23 of various ring size was achieved either via ‘direct amide cyclization’ by treatment of 2‐benzamido‐2‐benzyl‐ω‐hydroxy‐N,N‐dimethylalkanamides 21 in toluene at 90 – 110° with HCl gas or by ‘ring transformation’ of 4‐benzyl‐4‐(ω‐hydroxyalkyl)‐2‐phenyl‐1,3‐oxazol‐5(4H)‐ones under the same conditions. The precursors were obtained by C‐alkylations of 4‐benzyl‐2‐phenyl‐1,3‐oxazol‐5(4H)‐one

  各种环大小的α-苯甲酰胺基-α-苄基内酯23的合成可通过在90°C的甲苯中处理2-苯甲酰胺基-2-苄基-ω-羟基N，N-二甲基烷酰胺21的“直接酰胺环化”来实现–在相同条件下用HCl气体或通过4-苄基-4-（ω-羟烷基）-2-苯基-1,3-恶唑-5（4 H）-1的“环转化”至110° 。前体是通过4-苄基-2-苯基-1,3-恶唑-5（4 H）-one（15）与THP-或TBDMS保护的ω的C-烷基化获得的羟烷基碘化物 用Me 2 NH处理使THP保护的恶唑酮开环，然后使OH基脱保护，得到二酰胺21；而用TBAF对TBDMS系列的恶唑酮25脱保护，然后用HCl气体处理，得到相应的内酯23。一锅反应。
• Hydroxylated Long-Chain Resveratrol Derivatives Useful as Neurotrophic Agents
  申请人：Luu Bang

  公开号：US20100048731A1

  公开（公告）日：2010-02-25

  The present invention relates to a compound of general formula (I) below in which R 1 , R 2 and R 3 represent, independently of one another, a hydrogen atom or a C 1 -C 6 alkyl group or a (C 1 -C 6 alkyl)carbonyl group, R 4 , R 5 , R 6 and R 7 represent a hydrogen or a C 1 -C 6 alkyl group, a C1-C6 alkoxy group or a (C 1 -C 6 alkyl)carbonyloxy group, and n is an integer between 8 and 20, or its pharmaceutically acceptable addition salts, isomers, enantiomers and diastereoisomers, and also mixtures thereof. The invention also relates to a pharmaceutical composition comprising the compound and to the use thereof as a neurotrophic agent.

  本发明涉及以下通式（I）中的化合物，其中R1、R2和R3分别独立地表示氢原子或C1-C6烷基或（C1-C6烷基）羰基，R4、R5、R6和R7表示氢或C1-C6烷基、C1-C6烷氧基或（C1-C6烷基）羰氧基，n为8至20之间的整数，或其药学上可接受的加合盐、异构体、对映体和非对映体，以及它们的混合物。该发明还涉及包含该化合物的药物组合物以及其作为神经营养因子的用途。
• Tailoring Reaction Selectivity by Modulating a Catalytic Diad on a Foldamer Scaffold
  作者：Mary Katherine Andrews、Xinyu Liu、Samuel H. Gellman

  DOI：10.1021/jacs.1c11542

  日期：2022.2.9

  of a tunable molecular scaffold to align a reactive diad for bifunctional catalysis can reveal relationships between functional group identity and reactivity that might otherwise be impossible to identify. Here we use an α/β-peptide helix to show that an aligned pair of primary amine groups is uniquely competent to catalyze crossed aldol condensations with an aryl aldehyde as the electrophile. Geometrically

  使用可调分子支架来排列双功能催化的反应性二联体可以揭示功能组身份和反应性之间的关系，否则可能无法识别。在这里，我们使用 α/β-肽螺旋来表明一对对齐的伯胺基团具有独特的能力，可以催化以芳基醛作为亲电子试剂的交叉醛醇缩合。一个胺基是仲胺基团或两个胺基都是仲胺基团的几何相似的二元组是其他类型的醛醇缩合的良好催化剂，但不适用于涉及芳基醛的醛醇缩合。催化功效需要通过循环约束预先组织螺旋形成的 β-氨基酸残基。显示伯胺二联体的常规肽（仅α-氨基酸残基）是不良催化剂，
• [EN] ORGANIC SEMICONDUCTING POLYMERS<br/>[FR] POLYMÈRES SEMI-CONDUCTEURS ORGANIQUES
  申请人：MERCK PATENT GMBH

  公开号：WO2020161052A1

  公开（公告）日：2020-08-13

  The invention relates to novel photo-crosslinkable organic semiconducting (OSC) polymers, to methods for their preparation and educts or intermediates used therein, to compositions and formulations containing them, to the use of the polymers and compositions as organic semiconductors in, or for the preparation of, organic electronic (OE) devices, especially organic photovoltaic (OPV) devices, perovskite-based solar cell (PSC) devices, organic photo-detectors (OPD), organic field effect transistors (OFET)and organic light emitting diodes (OLED), and to OE, OPV, PSC, OPD, OFET and OLED devices comprising these polymers or compositions.

  本发明涉及一种新型光交联有机半导体（OSC）聚合物，以及其制备方法中使用的原料或中间体，包含它们的组合物和配方，将这些聚合物和组合物作为有机半导体在有机电子（OE）器件中使用或用于其制备，尤其是有机光伏（OPV）器件、钙钛矿太阳能电池（PSC）器件、有机光探测器（OPD）、有机场效应晶体管（OFET）和有机发光二极管（OLED），以及包含这些聚合物或组合物的OE、OPV、PSC、OPD、OFET和OLED器件。