tert-butyl(tetradec-13-ynyloxy)dimethylsilane

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tert-butyl(tetradec-13-ynyloxy)dimethylsilane
• 英文别名: tert-butyl-dimethyl-tetradec-13-ynoxysilane
• 化学式: C₂₀H₄₀OSi
• 分子量: 324.623
• InChiKey: MNVFCCJAKLSKPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.93
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tert-butyl(tetradec-13-ynyloxy)dimethylsilane 在 喹啉 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 以100%的产率得到Tert-butyl-dimethyl-tetradec-13-enoxysilane
  参考文献：
  名称：

  Fine-tuning latent fingerprint detection on paper using 1,2-indanedione bi-functional reagents

  摘要：

  In order to address the need for consistency and generality in chemical methods developed for detection of latent fingerprints on paper substrates, a practical protocol was developed using 1,2-indanedione-based bi-functional reagents. A series of novel bi-functional reagents were designed and synthesized using a concise, five-step sequence. An optimized development condition that is tailored to the type of paper substrate that requires processing was discovered, allowing potential application in practical criminal work where evidence processing is an irreversible process. The study also provided an insight to the underlying mechanism of interaction between the bi-functional reagent and fingerprint residue. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.07.072
• 作为产物：
  描述：

  12-溴-1-十二烷醇 在 咪唑 、 4-二甲氨基吡啶 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 tert-butyl(tetradec-13-ynyloxy)dimethylsilane
  参考文献：
  名称：

  通过调节 Foldamer 支架上的催化二联体来调整反应选择性

  摘要：

  使用可调分子支架来排列双功能催化的反应性二联体可以揭示功能组身份和反应性之间的关系，否则可能无法识别。在这里，我们使用 α/β-肽螺旋来表明一对对齐的伯胺基团具有独特的能力，可以催化以芳基醛作为亲电子试剂的交叉醛醇缩合。一个胺基是仲胺基团或两个胺基都是仲胺基团的几何相似的二元组是其他类型的醛醇缩合的良好催化剂，但不适用于涉及芳基醛的醛醇缩合。催化功效需要通过循环约束预先组织螺旋形成的 β-氨基酸残基。显示伯胺二联体的常规肽（仅α-氨基酸残基）是不良催化剂，

  DOI：

  10.1021/jacs.1c11542

文献信息

• Hydroxylated Long-Chain Resveratrol Derivatives Useful as Neurotrophic Agents
  申请人：Luu Bang

  公开号：US20100048731A1

  公开（公告）日：2010-02-25

  The present invention relates to a compound of general formula (I) below in which R 1 , R 2 and R 3 represent, independently of one another, a hydrogen atom or a C 1 -C 6 alkyl group or a (C 1 -C 6 alkyl)carbonyl group, R 4 , R 5 , R 6 and R 7 represent a hydrogen or a C 1 -C 6 alkyl group, a C1-C6 alkoxy group or a (C 1 -C 6 alkyl)carbonyloxy group, and n is an integer between 8 and 20, or its pharmaceutically acceptable addition salts, isomers, enantiomers and diastereoisomers, and also mixtures thereof. The invention also relates to a pharmaceutical composition comprising the compound and to the use thereof as a neurotrophic agent.

  本发明涉及以下通式（I）中的化合物，其中R1、R2和R3分别独立地表示氢原子或C1-C6烷基或（C1-C6烷基）羰基，R4、R5、R6和R7表示氢或C1-C6烷基、C1-C6烷氧基或（C1-C6烷基）羰氧基，n为8至20之间的整数，或其药学上可接受的加合盐、异构体、对映体和非对映体，以及它们的混合物。该发明还涉及包含该化合物的药物组合物以及其作为神经营养因子的用途。
• Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation
  作者：Frédérique Hauss、Jiawei Liu、Alessandro Michelucci、Djalil Coowar、Eleonora Morga、Paul Heuschling、Bang Luu

  DOI：10.1016/j.bmcl.2007.05.037

  日期：2007.8

  The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and (omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies. (c) 2007 Elsevier Ltd. All rights reserved.
• Tailoring Reaction Selectivity by Modulating a Catalytic Diad on a Foldamer Scaffold
  作者：Mary Katherine Andrews、Xinyu Liu、Samuel H. Gellman

  DOI：10.1021/jacs.1c11542

  日期：2022.2.9

  of a tunable molecular scaffold to align a reactive diad for bifunctional catalysis can reveal relationships between functional group identity and reactivity that might otherwise be impossible to identify. Here we use an α/β-peptide helix to show that an aligned pair of primary amine groups is uniquely competent to catalyze crossed aldol condensations with an aryl aldehyde as the electrophile. Geometrically

  使用可调分子支架来排列双功能催化的反应性二联体可以揭示功能组身份和反应性之间的关系，否则可能无法识别。在这里，我们使用 α/β-肽螺旋来表明一对对齐的伯胺基团具有独特的能力，可以催化以芳基醛作为亲电子试剂的交叉醛醇缩合。一个胺基是仲胺基团或两个胺基都是仲胺基团的几何相似的二元组是其他类型的醛醇缩合的良好催化剂，但不适用于涉及芳基醛的醛醇缩合。催化功效需要通过循环约束预先组织螺旋形成的 β-氨基酸残基。显示伯胺二联体的常规肽（仅α-氨基酸残基）是不良催化剂，
• Fine-tuning latent fingerprint detection on paper using 1,2-indanedione bi-functional reagents
  作者：Jisun Lee、Madeleine M. Joullié

  DOI：10.1016/j.tet.2015.07.072

  日期：2015.10

  In order to address the need for consistency and generality in chemical methods developed for detection of latent fingerprints on paper substrates, a practical protocol was developed using 1,2-indanedione-based bi-functional reagents. A series of novel bi-functional reagents were designed and synthesized using a concise, five-step sequence. An optimized development condition that is tailored to the type of paper substrate that requires processing was discovered, allowing potential application in practical criminal work where evidence processing is an irreversible process. The study also provided an insight to the underlying mechanism of interaction between the bi-functional reagent and fingerprint residue. (C) 2015 Elsevier Ltd. All rights reserved.