N-[(1R)-1-methyl-2-propen-1-yl]-2-pyridinesulfonamide | 861848-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[(1R)-1-methyl-2-propen-1-yl]-2-pyridinesulfonamide
• 英文别名: (R)-2-pyridinesulfonyl-N-(α-methylallyl)amine；N-[(2R)-but-3-en-2-yl]pyridine-2-sulfonamide
• CAS: 861848-44-4
• 化学式: C₉H₁₂N₂O₂S
• 分子量: 212.272
• InChiKey: OZEWSSZHMFFCID-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[(1R)-1-methyl-2-propen-1-yl]-2-pyridinesulfonamide 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 (叔丁基亚氨基)三(吡咯烷)膦 、 肼 作用下， 以 乙醇 、 二氯甲烷 、 异丙醇 为溶剂， 反应 7.0h， 生成 1,3,4,5-tetradeoxy-3-{[(2-{[(1-methylethyl)oxy]carbonyl}phenyl)carbonyl]amino}-1-[[(1R)-1-methyl-2-propen-1-yl](2-pyridinylsulfonyl)amino]-L-threo-pent-4-enitol
  参考文献：
  名称：

  Development of a Robust Ring-Closing Metathesis Reaction in the Synthesis of SB-462795, a Cathepsin K Inhibitor

  摘要：

  The development of a robust and high-yielding ring-closing metathesis (RCM) reaction and its demonstration on multikilogram scale are described. A detailed understanding of the impact of impurities on the RCM reaction was achieved using a variety of chemical and statistical methods. Specifically, individual impurities were evaluated in spiking studies to identify those that negatively affected the RCM reaction. Projection methods (PCA and PLS) were applied to historical data to identify the main sources of variation in starting material quality and determine the main detrimental impurities that impeded the RCM reaction. The synthesis of the starting material was then modified to adequately control these key impurities, which in turn ensured a robust RCM process. Finally, the robustness of the RCM reaction was assessed using a probability-based approach.

  DOI：

  10.1021/op700288p
• 作为产物：
  描述：

  吡啶-2-磺酰氯 、 [(1R)-1-甲基-2-丙烯-1-基]胺盐酸盐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以76%的产率得到N-[(1R)-1-methyl-2-propen-1-yl]-2-pyridinesulfonamide
  参考文献：
  名称：

  Method of Preparation of Benzofuran-2-Carboxylic Acid -Amide

  摘要：

  这项发明涉及一种制备苯并呋喃-2-羧酸{(S)-3-甲基-1-[(4S,7R)-7-甲基-3-氧代-1-(吡啶-2-磺酰基)-氮杂庚-4-基甲酰]-丁基}-酰胺的方法。

  公开号：

  US20080262224A1

文献信息

• Method of Preparation of Benzofuran-2-Carboxylic Acid -Amide
  申请人：Clark William M.

  公开号：US20080262224A1

  公开（公告）日：2008-10-23

  This invention relates to a method of preparation of benzofuran-2-carboxylic acid (S)-3-methyl- 1 -[(4S,7R)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide.

  这项发明涉及一种制备苯并呋喃-2-羧酸(S)-3-甲基-1-[(4S,7R)-7-甲基-3-氧代-1-(吡啶-2-磺酰基)-氮杂庚-4-基甲酰]-丁基}-酰胺的方法。
• METHOD OF PREPARATION OF BENZOFURAN-2-CARBOXYLIC ACID (S)-3-METHYL-1- ((4S, 7R)-7METHYL-3-OXO-1-(PYRIDINE-2-SULFONYL)-AZ EPAN-4-YLCARBAMOYL-BUTYL)-AMIDE
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1713790A2

  公开（公告）日：2006-10-25
• [EN] METHOD OF PREPARATION OF BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[(4S, 7R)-7METHYL-3-OXO-1-(PYRIDINE-2-SULFONYL)-AZEPAN-4-YLCARBAMOYL]-BUTYL}-AMIDE<br/>[FR] PROCEDE DE PREPARATION D'ACIDE BENZOFURAN-2-CARBOXYLIQUE {(S)-3-METHYL-1-[(4S, 7R)-7METHYL-3-OXO-1-(PYRIDINE-2-SULFONYL)-AZEPAN-4-YLCARBAMOYL]-BUTYL}-AMIDE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005069981A2

  公开（公告）日：2005-08-04

  This invention relates to a method of preparation of benzofuran-2-carboxylic acid (S)-3-methyl-1[(4S,7R)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide.
• Development of a Robust Ring-Closing Metathesis Reaction in the Synthesis of SB-462795, a Cathepsin K Inhibitor
  作者：Huan Wang、Steven N. Goodman、Qunying Dai、Gregory W. Stockdale、William M. Clark

  DOI：10.1021/op700288p

  日期：2008.3.1

  The development of a robust and high-yielding ring-closing metathesis (RCM) reaction and its demonstration on multikilogram scale are described. A detailed understanding of the impact of impurities on the RCM reaction was achieved using a variety of chemical and statistical methods. Specifically, individual impurities were evaluated in spiking studies to identify those that negatively affected the RCM reaction. Projection methods (PCA and PLS) were applied to historical data to identify the main sources of variation in starting material quality and determine the main detrimental impurities that impeded the RCM reaction. The synthesis of the starting material was then modified to adequately control these key impurities, which in turn ensured a robust RCM process. Finally, the robustness of the RCM reaction was assessed using a probability-based approach.
• Large-scale synthesis of SB-462795, a cathepsin K inhibitor: the RCM-based approaches
  作者：Huan Wang、Hayao Matsuhashi、Brian D. Doan、Steven N. Goodman、Xi Ouyang、William M. Clark

  DOI：10.1016/j.tet.2009.06.022

  日期：2009.8

  Two stereoselective syntheses of SB-462795, a highly potent cathepsin K inhibitor, are described. Both routes feature a C5-C6 disconnection by ring closing metathesis to construct an azepane ring and are amenable to large-scale manufacturing. (C) 2009 Elsevier Ltd. All rights reserved.