溴苯膦 | 21609-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 溴苯膦
• 中文别名: 苯溴硝硫磷；对溴磷；O-(4-溴-2,5-二氯苯基)-O-甲基苯基硫代膦酸酯；溴苯磷；O-(4-溴-2，5-二氯苯基)-O-甲基苯基硫代膦酸酯
• 英文名称: leptophos
• 英文别名: (4-bromo-2,5-dichlorophenoxy)-methoxy-phenyl-sulfanylidene-λ5-phosphane
• CAS: 21609-90-5
• 化学式: C₁₃H₁₀BrCl₂O₂PS
• mdl: MFCD00128037
• 分子量: 412.071
• InChiKey: CVRALZAYCYJELZ-UHFFFAOYSA-N

物化性质

• 稳定性/保质期：
  避免接触强氧化剂。

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

... 在应用2,240克活性成分/公顷于狗牙根（百慕大草）后42天 ... 其代谢物4-溴-2,5-二氯苯酚1.30 ppm ... 被回收。

... 42 DAYS AFTER APPLICATION OF 2,240 G AI/HA TO CYNODON DACTYLON (BERMUDA GRASS) ... /ITS/ METABOLITE 4-BROMO-2,5-DICHLOROPHENOL 1.30 PPM, /WAS/ ... RECOVERED.

来源:Hazardous Substances Data Bank (HSDB)

代谢

小鼠对乐果的生物转化是迅速的（只在粪便和尿液中发现了少量的母化合物）并且可以预测代谢物，已识别出4-溴-2,5-二氯苯酚，大部分是结合态的，占了25毫克/千克剂量的[phenoxy-(14)C]乐果的96%，并且暂时识别出了O-去甲基乐果的氧合物的(1.1%)。使用[phenyl-(14)C]乐果进行的补充研究表明，O-去甲基乐果的氧合物再次只是尿液中的一个小部分代谢物，并且甲基苯基磷硫代酸(56.6%)、甲基苯基磷onic酸(17.9%)和苯基磷onic酸(15.5%)占了尿液标记的90%。O-去甲基化途径在乐果的生物转化中的重要性通过排泄(15.5%)的苯基磷onic酸得以揭示。尿液中没有O-去甲基乐果和苯基磷硫代酸的存在意味着与产生4-溴-2,5-二氯苯酚相比，谷胱甘肽介导的乐果O-去甲基化是相对不重要的。

THE BIOTRANSFORMATION IN MICE OF LEPTOPHOS IS RAPID (ONLY SMALL AMOUNTS OF THE PARENT COMPOUND ARE FOUND IN FECES & IN URINE) & PREDICTABLE METABOLITES ARE IDENTIFIED ... 4-BROMO-2,5-DICHLOROPHENOL, MOSTLY CONJUGATED, ACCOUNTED FOR 96% OF A 25 MG/KG DOSE OF [PHENOXY-(14)C]LEPTOPHOS, & TENTATIVE IDENTIFICATION OF THE OXON OF O-DEMETHYL-LEPTOPHOS (1.1%) WAS MADE. COMPLEMENTARY STUDIES WITH [PHENYL-(14)C]LEPTOPHOS REVEALED THAT THE OXON OF O-DEMETHYL-LEPTOPHOS WAS AGAIN ONLY A MINOR URINARY METABOLITE, & THAT METHYL PHENYLPHOSPHONOTHIOIC ACID (56.6%), METHYL PHENYLPHOSPHONIC ACID (17.9%), & PHENYLPHOSPHONIC ACID (15.5%) ACCOUNTED FOR 90% OF THE URINARY LABEL. THE EXTENT OF THE IMPORTANCE OF O-DEMETHYLATION PATHWAYS IN THE BIOTRANSFORMATION OF LEPTOPHOS IS REVEALED BY THE EXCRETION (15.5%) OF PHENYLPHOSPHONIC ACID. THE ABSENCE OF O-DEMETHYL-LEPTOPHOS & PHENYLPHOSPHONOTHIOIC ACID FROM THE URINE MEANS THAT GLUTATHIONE-MEDIATED O-DEMETHYLATION OF LEPTOPHOS IS RELATIVELY UNIMPORTANT, COMPARED WITH THE PRODUCTION OF 4-BROMO-2,5-DICHLOROPHENOL.

来源:Hazardous Substances Data Bank (HSDB)

代谢

乐果氧在易感物种（猫和鸡的肝微粒体部分）中适度被水解，在非易感物种（大鼠和仓鼠的肝微粒体部分）中则被大量水解。乐果的解毒速率与测试物种对迟发性神经毒性的易感性呈负相关。

LEPTOPHOS OXON WAS MODERATELY HYDROLYZED BY SUSCEPTIBLE SPECIES (LIVER MICROSOMAL FRACTIONS FROM CATS & HENS) & GREATLY HYDROLYZED BY NONSUSCEPTIBLE SPECIES (LIVER MICROSOMAL FRACTIONS FROM RATS & HAMSTERS). RATE OF DETOXIFICATION OF LEPTOPHOS IS INVERSELY CORRELATED WITH IN VIVO SUSCEPTIBILITY OF TESTED SPECIES TO DELAYED NEUROTOXICITY.

来源:Hazardous Substances Data Bank (HSDB)

代谢

当乐脱磷通过气管内给药给大鼠时，它的代谢速率与口服给药相似。大鼠体内的代谢物与小鼠体内的相同，尽管保留了P=S键的单个代谢物的比例要小得多。这是出乎意料的，因为通常大鼠比小鼠更广泛地氧化P=S基团。连续三天以9.1和0.91毫克/千克剂量给药的大鼠分别排泄了30%和73%的剂量，作为三种已知磷酸的混合物，同时每次给药都伴随着相同产量的4-溴-2,5-二氯苯酚（12±1%）。

WHEN LEPTOPHOS WAS DOSED ENDOTRACHEALLY TO THE RAT, IT WAS METABOLIZED AT A RATE SIMILIAR TO THAT OF AN ORAL DOSE. THE METABOLITES IN THE RAT ARE THE SAME AS THOSE IN THE MOUSE, ALTHOUGH THE PROPORTION OF THE SINGLE METABOLITE THAT HAD RETAINED THE P=S LINKAGE WAS MUCH LESS. THIS IS NOT EXPECTED, AS THE RAT USUALLY MORE EXTENSIVELY OXIDIZES THE P=S GROUP THAN DOES THE MOUSE. RATS DOSED ON THREE CONSECUTIVE DAYS WITH 9.1 & 0.91 MG/KG LEPTOPHOS EXCRETED 30% & 73% RESPECTIVELY OF THE DOSE AS A MIXTURE OF THE THREE KNOWN PHOSPHORUS ACIDS, ACCOMPANIED BY THE SAME YIELD (12 + OR - 1%) OF 4-BROMO-2,5-DICHLOROPHENOL AT EACH DOSAGE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 主要影响运动神经

Neurotoxin - Predominantly motor

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

1. 确保气道通畅，如有必要，通过抽吸分泌物来清理。如果呼吸抑制，通过机械辅助肺通气给予氧气。在给予阿托品之前尽可能提高组织氧合，以最小化心室颤动的风险。在严重中毒的情况下，可能需要机械辅助肺通气数天。2. 给予硫酸阿托品静脉注射，如果静脉注射不可能，则肌内注射。在中度到重度中毒的情况下：成人剂量和12岁以上的儿童：每15分钟重复给予0.4-2.0毫克，直到达到阿托品化。维持阿托品化，根据体重每千克重复给予0.02-0.05毫克的剂量。/有机磷农药/

1. INSURE THAT A CLEAR AIRWAY EXISTS BY ASPIRATION OF SECRETIONS IF NECESSARY. ADMIN OXYGEN BY MECHANICALLY ASSISTED PULMONARY VENTILATION IF RESPIRATION IS DEPRESSED. IMPROVE TISSUE OXYGENATION AS MUCH AS POSSIBLE BEFORE ADMIN ATROPINE TO MINIMIZE RISK OF VENTRICULAR FIBRILLATION. IN SEVERE POISONINGS, IT MAY BE NECESSARY TO SUPPORT PULMONARY VENTILATION MECHANICALLY FOR SEVERAL DAYS. 2. ADMIN ATROPINE SULFATE IV, OR IM IF IV INJECTION IS NOT POSSIBLE. ... IN MODERATELY SEVERE POISONING: ADULT DOSAGE AND CHILDREN OVER 12 YR: 0.4-2.0 MG REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED. MAINTAIN ATROPINIZATION WITH REPEATED DOSAGE OF 0.02-0.05 MG/KG BODY WEIGHT. /ORGANOPHOSPHATE PESTICIDES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

2. 严重中毒的人可能对阿托品表现出显著的耐受性；可能需要两倍或更多倍于上述建议的剂量。可以根据需要增加阿托品的剂量并缩短给药间隔以控制症状。当阿托品需求量很大时，可能需要持续静脉输注阿托品。逆转毒蕈碱样症状和体征，而不是任意剂量限制，是期望的终点。应尽可能使用不含防腐剂的阿托品产品。注意：未中毒或仅轻微有机磷中毒的人可能会因大剂量阿托品出现阿托品中毒的迹象。发热、肌肉颤动和谵妄是阿托品中毒的主要迹象。如果患者在完全阿托品化时出现这些症状，应暂时停止阿托品给药，同时重新评估中毒的严重程度。/有机磷杀虫剂/

2. SEVERELY POISONED INDIVIDUALS MAY EXHIBIT REMARKABLE TOLERANCE TO ATROPINE; TWO OR MORE TIMES THE DOSAGES SUGGESTED ABOVE MAY BE NEEDED. THE DOSE OF ATROPINE MAY BE INCREASED AND THE DOSING INTERVAL DECREASED AS NEEDED TO CONTROL SYMPTOMS. CONTINUOUS IV INFUSION OF ATROPINE MAY BE NECESSARY WHEN ATROPINE REQUIREMENTS ARE MASSIVE. REVERSAL OF MUSCARINIC SYMPTOMS AND SIGNS, NOT AN ARBITRARY DOSE LIMIT, IS THE DESIRED END-POINT. PRESERVATIVE-FREE ATROPINE PRODUCTS SHOULD BE USED WHENEVER POSSIBLE. NOTE: PERSONS NOT POISONED OR ONLY SLIGHTLY POISONED BY ORGANOPHOSPHATES MAY DEVELOP SIGNS OF ATROPINE TOXICITY FROM SUCH LARGE DOSES. FEVER, MUSCLE FIBRILLATIONS, AND DELIRIUM ARE THE MAIN SIGNS OF ATROPINE TOXICITY. IF THESE APPEAR WHILE THE PATIENT IS FULLY ATROPINIZED, ATROPINE ADMINISTRATION SHOULD BE DISCONTINUED, AT LEAST TEMPORARILY, WHILE THE SEVERITY OF POISONING IS REEVALUATED. /ORGANOPHOSPHATE PESTICIDES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

3. 在给予解磷定之前，抽取（肝素化）血液样本进行胆碱酯酶分析，因为解磷定往往会逆转胆碱酯酶的抑制。4. 在严重中毒的情况下给予解磷定（普罗帕明，2-PAM）……在这种情况下，呼吸抑制、肌肉无力和抽搐都非常严重。……成人剂量（以及12岁以上的儿童）：静脉注射1.0-2.0克，每分钟不超过0.2克。儿童剂量（12岁以下）：静脉注射20-50毫克/千克（根据严重程度），每分钟注射的总量不超过一半。剂量……可以在1-2小时后重复，然后在需要时每10-12小时给药一次。在非常严重的中毒情况下，剂量……可以加倍。/有机磷农药/

3. DRAW BLOOD SAMPLE (HEPARINIZED) FOR CHOLINESTERASE ANALYSIS BEFORE ADMINISTRATION OF PRALIDOXIME, WHICH TENDS TO REVERSE THE CHOLINESTERASE DEPRESSION. 4. ADMIN PRALIDOXIME (PROTOPAM, 2-PAM) IN CASES OF SEVERE POISONING...IN WHICH RESP DEPRESSION, MUSCLE WEAKNESS & TWITCHINGS ARE SEVERE. ... ADULT DOSAGE AND CHILDREN OVER 12): GIVE 1.0-2.0 G IV @ NO MORE THAN 0.2 G/MIN. CHILD'S DOSE (UNDER 12 YR): GIVE 20-50 MG/KG (DEPENDING ON SEVERITY) IV, INJECTING NO MORE THAN HALF TOTAL DOSE/MIN. DOSAGE...MAY BE REPEATED IN 1-2 HR, THEN @ 10-12 HR INTERVAL IF NEEDED. IN VERY SEVERE POISONINGS, DOSAGE ... MAY BE DOUBLED. /ORGANOPHOSPHATE PESTICIDES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

4. 准备好机械辅助呼吸，如果呼吸抑制...下降...。5. 对于因皮肤、衣物、头发和/或眼睛接触有机磷污染而中毒的患者，必须在进行复苏和解毒措施的同时进行去污处理，以保护生命。... 6. 如果...摄入的量足以引起中毒，必须清空胃和肠道。A. 通过插管、抽吸和灌洗清空胃，使用等渗盐水中的活性炭悬浮液。必须采取严格措施保护呼吸道免受反流的物质吸入。如果受害者昏迷或反应迟钝，在胃插管前插入带套囊的气管内导管。在胃插管和灌洗过程中，保持受害者头部低于胃部水平...。保持受害者头部向左转。/有机磷杀虫剂/

4. BE PREPD TO ASSIST PULMONARY VENTILATION MECHANICALLY IF RESP ... DEPRESSED ... . 5. IN PATIENTS WHO HAVE BEEN POISONED BY ORGANOPHOSPHATE CONTAMINATION OF SKIN, CLOTHING, HAIR, AND/OR EYES, DECONTAMINATION MUST PROCEED CONCURRENTLY WITH WHATEVER RESUSCITATIVE AND ANTIDOTAL MEASURES ARE NECESSARY TO PRESERVE LIFE. ... 6. IF ... INGESTED IN QUANTITY PROBABLY SUFFICIENT TO CAUSE POISONING, THE STOMACH AND INTESTINE MUST BE EMPTIED. A. EMPTY THE STOMACH BY INTUBATION, ASPIRATION, AND LAVAGE, USING SLURRY OF ACTIVATED CHARCOAL IN ISOTONIC SALINE. RIGOROUS PRECAUTIONS MUST BE TAKEN TO PROTECT THE AIRWAY FROM ASPIRATION OF REGURGITATED. IF VICTIM IS UNCONSCIOUS OR OBTUNDED, INSERT A CUFFED ENDOTRACHEAL TUBE PRIOR TO GASTRIC INTUBATION. KEEP VICTIM'S HEAD BELOW LEVEL OF STOMACH DURING GASTRIC INTUBATION AND LAVAGE ... . KEEP VICTIM'S HEAD TURNED TO THE LEFT. /ORGANOPHOSPHATE PESTICIDES/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在给予50或250毫克/千克剂量后，血浆中的福斯维尔浓度在3小时内达到最大值，然后迅速下降；72小时后没有检测到残留物。从脂肪中消除非常缓慢。

AFTER 50 OR 250 MG/KG DOSE, PHOSVEL CONCN IN PLASMA REACHED MAX IN 3 HR, THEN DECLINED RAPIDLY; AFTER 72 HR NO RESIDUES WERE DETECTABLE. ELIMINATION FROM FAT WAS VERY SLOW.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

尽管有些倾向储存，但作为水溶性代谢物形式的乐果，会迅速被啮齿类动物排泄，几乎在48到72小时内完全消除。在以25毫克/公斤的速率喂食(14)C标记的乐果的小鼠中，苯氧基团的排泄速率明显快于苯基团；在处理后的长达6天内，在尿液中发现了放射性活性。

IN SPITE OF SOME TENDENCY TO STORAGE, LEPTOPHOS, IN THE FORM OF WATER-SOLUBLE METABOLITES, IS EXCRETED RAPIDLY BY RODENTS, WITH VIRTUALLY COMPLETE ELIMINATION IN 48 TO 72 HR. IN MICE FED (14)C LEPTOPHOS AT A RATE OF 25 MG/KG THE RATE OF EXCRETION OF THE PHENOXY MOIETY WAS DISTINCTLY FASTER THAN THAT OF THE PHENYL MOIETY; RADIOACTIVITY WAS FOUND IN THE URINE AS LONG AS 6 DAYS AFTER TREATMENT.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在大鼠中，单次给药或连续给药最后一次后，放射性碳的排泄在72小时内基本完成。在最后一次给药后六天，(14)C的最高浓度在肝脏中，但它只占给药总量的不到0.25%。在大鼠尿液中，超过97%的放射性来自于接受(14)C磷脂酰胆碱的有机溶性部分。

IN RATS, EXCRETION OF RADIOACTIVE CARBON WAS ESSENTIALLY COMPLETE IN 72 HR FOLLOWING A SINGLE DOSE OR THE LAST OF A SERIES OF DOSES OF (14)C LEPTOPHOS. SIX DAYS AFTER THE LAST DOSE, THE HIGHEST CONCN OF (14)C WAS IN THE LIVER, BUT IT CONSTITUTED LESS THAN 0.25% OF THE TOTAL DOSE. MORE THAN 97% OF THE RADIOACTIVITY IN THE URINE OF RATS THAT HAD RECEIVED (14)C LEPTOPHOS WAS ORGANOSOLUBLE.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在给母鸡的鸡冠施用亚神经毒剂量的50毫克/千克的^14C苯基亮磷后... 在20天的实验期间，总共吸收了35.4%的施用剂量。放射性在施用后12小时达到峰值，为剂量的17.1%；20天后仍有5%的剂量残留。20天后放射性最高的组织依次为肌肉、大脑、脊髓、大肠内容物和胆汁。尿粪排泄占总施用剂量的24.3%；呼出的二氧化碳占1.3%，鸡蛋占4.5%。

... FOLLOWING A SINGLE DOSE OF (14)C PHENYL LEPTOPHOS APPLIED TO THE COMBS OF HENS AT A SUBNEUROTOXIC RATE OF 50 MG/KG ... A TOTAL OF 35.4% OF THE APPLIED DOSE WAS ABSORBED DURING A 20-DAY EXPERIMENT. RADIOACTIVITY REACHED A PEAK OF 17.1% OF THE DOSE IN 12 HR AFTER APPLICATION; 5% OF THE DOSE STILL REMAINED AFTER 20 DAYS. THE HIGHEST (14)C CONCN AFTER 20 DAYS WERE IN MUSCLE, BRAIN, SPINAL CORD, CONTENTS OF THE LARGE INTESTINE, & BILE, IN THAT ORDER. COMBINED URINARY-FECAL EXCRETION ACCOUNTED FOR 24.3% OF THE APPLIED DOSE; EXPIRED CARBON DIOXIDE ACCOUNTED FOR 1.3% & EGG ACCOUNTED FOR 4.5%.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 储存条件：
  温度：0-6℃

制备方法与用途

Leptophos是一种有机磷酸酯杀虫剂。

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  ——	Phenyl-phosphonothioic acid O,O-bis-(4-bromo-2,5-dichloro-phenyl) ester	50654-88-1	C18H9Br2Cl4O2PS	621.928

反应信息

• 作为反应物：
  描述：

  甲醇 、 溴苯膦 在 高氯酸 、 (S)-{2-[2-(4-tert-butyl)oxazolinyl]phenyl-C₁,N}(trifluoromethylpyridine)(aqua)-palladium(II) triflate 作用下， 生成 苯基硫代膦酸二甲酯
  参考文献：
  名称：

  (S)-4-tert-Butyl-2-phenyl-2-oxazoline derived palladacycles as efficient catalysts for the decomposition of P=S pesticides

  摘要：

  Three palladacycles with N,N-trans coordination, (S)-{2-[2-(4-tert-butyl) oxazolinyl]phenyl-C-1,N}(4-R-pyridine)(aqua)(n)palladium(II) triflate (R = CF3, n = 1, 1; R = H, n = 0, 2; R = NMe2, n = 1, 3), have been prepared from the respective chloride precursors and were characterized with IR and H-1-NMR and elemental analyses. The crystal structures of 2 and a pincer complex (S, S)-{2,6-bis[2-(4-iso-propyl)oxazolinyl]phenyl-N,C-1,N}bromo- palladium(II) hydrate (5) were determined. For methanolysis of P = S pesticides, it was found that ortho-palladated complexes 1-3 effectively catalyzed the reaction; however, the pincer complex 4 with triflate counterion was much less active. Relative to the methoxide-promoted background reaction at (s)(s)pH 10.80, 1 mmol L-1 of palladacycles 1-3 can accelerate the methanolysis by 8.7 x 10(9), 1.5 x 10(9), and 1.0 x 10(8)-fold, respectively. For racemic P = S pesticides, such as letophos and EPN, it proved that there is no clear chiral discrimination during the catalysis. The reaction mechanism of the catalytic methanolysis was discussed according to the experimental results.

  DOI：

  10.1080/00958972.2010.491545
• 作为产物：
  描述：

  4-溴-2,5-二氯苯酚 在 苄基三乙基氯化铵 sodium hydroxide 、 potassium carbonate 作用下， 以 苯 为溶剂， 反应 3.75h， 生成 溴苯膦
  参考文献：
  名称：

  Purnanand; Danikhel, R. K., Synthesis, 1983, # 9, p. 731 - 733

  摘要：

  DOI：

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• Novel insecticides
  申请人：Syngenta Participations AG

  公开号：EP2540718A1

  公开（公告）日：2013-01-02

  Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.

  式I的化合物 其中取代基如权利要求1所定义，并且式I化合物的农药可接受盐以及所有立体异构体和互变异构形式可用作杀虫剂，并且可以按照已知的方法制备。
• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。

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