(2,3-Dichlor-4-formylphenoxy)essigsaeure | 16861-49-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,3-Dichlor-4-formylphenoxy)essigsaeure
• 英文别名: 2-(2,3-Dichloro-4-formylphenoxy)acetic acid
• CAS: 16861-49-7
• 化学式: C₉H₆Cl₂O₄
• 分子量: 249.05
• InChiKey: UHPBFMVUGRPHHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2,3-Dichlor-4-formylphenoxy)essigsaeure 以46%的产率得到
  参考文献：
  名称：

  BICKING J. B.; HOLTZ W. J.; WATSON S.; CRAGOE E. J., JR., J. MED. CHEM. , 1976, 19, NO 4, 530-535

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2,3-二氯-4-甲酰基苯氧基)乙酸乙酯 、 碳酸氢钠 以94%的产率得到
  参考文献：
  名称：

  BICKING J. B.; HOLTZ W. J.; WATSON S.; CRAGOE E. J., JR., J. MED. CHEM. , 1976, 19, NO 4, 530-535

  摘要：

  DOI：

文献信息

• (Vinylaryloxy)acetic acids. A new class of diuretic agents. 3. [(2-Nitro-1-alkenyl)aryloxy]acetic acids
  作者：Everett M. Schultz、John B. Bicking、Albert A. Deana、Norman P. Gould、Terence P. Strobaugh、L. Sherman Watson、Edward J. Cragoe

  DOI：10.1021/jm00228a009

  日期：1976.6

  A series of [(2-nitro-1-alkenyl)aryloxy]acetic acids was synthesized and tested in dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration; representative of these is (E)-[2,3-dichloro-4-(2-nitropropenyl)phenoxy]acetic acid (5). The most highly active compounds are qualitatively similar in action to [2,3-dichloro-4-(2-methylenebutyryl)phenoxylacetic acid (ethacrynic acid) in causing a prompt increase in the excretion of water and of sodium and chloride ions in approximately equimolar amounts but are three to five times as potent. Potassium ion excretion is increased but less markedly than sodium excretion.
• Nuhrich; Lablanche; Devaux, European Journal of Medicinal Chemistry, 1981, vol. 16, # 6, p. 551 - 555
  作者：Nuhrich、Lablanche、Devaux、et al.

  DOI：——

  日期：——
• (Vinylaryloxy)acetic acids. A new class of diuretic agents. 4. Various [(2-substituted and 2,2-disubstituted vinyl)aryloxy]acetic acids
  作者：Otto W. Woltersdorf、Charles M. Robb、John B. Bicking、L. Sherman Watson、Edward J. Cragoe

  DOI：10.1021/jm00229a024

  日期：1976.7

  A variety of [(2-substituted and 2,2-disubstituted vinyl)aryloxy]acetic acids was synthesized in which the substituents were primarily electron-withdrawing groups. These compounds were tested in dogs for their saluretic and diuretic properties. Many of the compounds exhibited significant activity; however, they were generally less potent than those reported in the three earlier papers in this series.
• NUHRICH, A.;LABLANCHE, C.;DEVAUX, G.;CARPY, A.;DUFOUR, P.;NGUYEN-BA, CANG+, EUR. J. MED. CHEM.-CHIM. THER., 1981, 16, N 6, 551-555
  作者：NUHRICH, A.、LABLANCHE, C.、DEVAUX, G.、CARPY, A.、DUFOUR, P.、NGUYEN-BA, CANG+

  DOI：——

  日期：——
• BICKING J. B.; ROBB C. M.; WATSON L. S.; CRAGOE E. J., JR., J. MED. CHEM. <JMCM-AR>, 1976, 19 NO 4, 544-547
  作者：BICKING J. B.、 ROBB C. M.、 WATSON L. S.、 CRAGOE E. J., JR.

  DOI：——

  日期：——